Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)

Stable Identifier
R-HSA-2022403
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Renin Bound to Renin Receptor Hydrolyzes Angiotensinogen to Yield Angiotensin I
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Renin bound to the (pro)renin receptor (ATP6AP2) hydrolyzes angiotensinogen to yield angiotensin-(1-10) (angiotensin I) (Nguyen et al. 2002). Binding to the (pro)renin receptor increases the catalytic efficiency of renin 4-fold (Nguyen et al. 2002). Aliskiren, a drug used clinically to treat hypertension, inhibits cleavage of angiotensinogen by renin (Gossas et al. 2011, Wood et al. 2003, reviewed in Gerc et al. 2009).

Literature References
PubMed ID Title Journal Year
12927775 Structure-based design of aliskiren, a novel orally effective renin inhibitor

Wood, JM, Maibaum, J, Rahuel, J, Grütter, MG, Cohen, NC, Rasetti, V, Rüger, H, Göschke, R, Stutz, S, Fuhrer, W, Schilling, W, Rigollier, P, Yamaguchi, Y, Cumin, F, Baum, HP, Schnell, CR, Herold, P, Mah, R, Jensen, C, O'Brien, E, Stanton, A, Bedigian, MP

Biochem Biophys Res Commun 2003
22193701 Aliskiren displays long-lasting interactions with human renin

Gossas, T, Vrang, L, Henderson, I, Sedig, S, Sahlberg, C, Lindström, E, Danielson, UH

Naunyn Schmiedebergs Arch Pharmacol 2011
12045255 Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin

Nguyen, G, Delarue, F, Burcklé, C, Bouzhir, L, Giller, T, Sraer, JD

J Clin Invest 2002
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Catalyst Activity
Catalyst Activity
Title
aspartic-type endopeptidase activity of Renin:Prorenin Receptor [plasma membrane]
Physical Entity
Activity
This event is regulated
Orthologous Events
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