Reactome: A Curated Pathway Database

Recruitment of SLP-76 to Gads

Stable Identifier
R-HSA-202241
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SLP-76 is an adaptor protein that links proximal and distal T cell receptor signaling events through its function as a molecular scaffold in the assembly of multi molecular signaling complexes. SLP-76 consists of three domains that mediate interactions with many different signaling proteins: an N-terminal acidic domain containing three tyrosine phosphorylation sites, a large central proline-rich region, and a C-terminal SH2 domain. The function of SLP-76 is dependent on its association with Gads. SLP-76 constitutively binds through its 'RxxK' motif in the proline rich region to the SH3 domain of Gads upon TCR activation.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events