Reactome | GSK3B [nucleoplasm]

GSK3B [nucleoplasm]

Stable Identifier

R-HSA-2022823

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Glycogen synthase kinase-3 beta, GSK3B_HUMAN

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Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        GSK3B phosphorylates p-NFE2L2 (Homo sapiens)
        
        GSK3B [nucleoplasm] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
24901984	Glycogen synthase kinase (GSK) 3β phosphorylates and protects nuclear myosin 1c from proteasome-mediated degradation to activate rDNA transcription in early G1 cells Von Euler, A, Borgonovo-Brandter, L, Lamont, D, Visa, N, Percipalle, P, Corcoran, M, Sarshad, AA, Al-Muzzaini, B	PLoS Genet.	2014

External Reference Information

External Reference

UniProt:P49841 GSK3B

Gene Names

GSK3B

Chain

chain:1-420

Reference Genes

BioGPS Gene:2932 GSK3B

COSMIC (genes):GSK3B GSK3B

CTD Gene:2932 GSK3B

dbSNP Gene:2932 GSK3B

ENSEMBL:ENSG00000082701 GSK3B

ENSEMBL:ENSG00000082701.17 GSK3B

HGNC:4617 GSK3B

KEGG Gene (Homo sapiens):2932 GSK3B

Monarch:2932 GSK3B

NCBI Gene:2932 GSK3B

OMIM:605004 GSK3B

UCSC:P49841 GSK3B

Reference Transcript

Other Identifiers

11744456_s_at

11754361_s_at

1253_at

16957843

209945_PM_s_at

209945_s_at

226183_PM_at

226183_at

226191_PM_at

226191_at

240562_PM_at

240562_at

242336_PM_at

242336_at

2691015

2691016

2691017

2691018

2691019

2691020

2691021

2691022

2691023

2691031

2691036

2691039

2691045

2691046

2691057

2691059

2691060

2691061

2691070

2691080

2691093

2691094

2691095

2691096

2691097

2691100

2691101

2691102

2691104

2691106

2691111

2932

3237612

40645_at

43373_s_at

49465_at

52456_at

8089801

A_23_P251342

A_24_P243044

GE56933

GE57725

GO:0000166

GO:0001837

GO:0001954

GO:0002020

GO:0002039

GO:0003170

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005975

GO:0005977

GO:0006091

GO:0006468

GO:0006886

GO:0006913

GO:0006914

GO:0006983

GO:0007005

GO:0007010

GO:0007155

GO:0007163

GO:0007212

GO:0007399

GO:0007623

GO:0008013

GO:0008092

GO:0008286

GO:0009968

GO:0010508

GO:0010628

GO:0010629

GO:0010822

GO:0010975

GO:0012501

GO:0016020

GO:0016055

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0018107

GO:0019082

GO:0019901

GO:0021766

GO:0023052

GO:0030010

GO:0030011

GO:0030154

GO:0030163

GO:0030424

GO:0030425

GO:0030516

GO:0030877

GO:0031175

GO:0031333

GO:0031334

GO:0031398

GO:0031625

GO:0032091

GO:0032092

GO:0032436

GO:0032515

GO:0032886

GO:0034236

GO:0034452

GO:0035556

GO:0036016

GO:0036211

GO:0042752

GO:0043066

GO:0043161

GO:0043226

GO:0043547

GO:0044782

GO:0045597

GO:0045719

GO:0045724

GO:0045732

GO:0046777

GO:0046825

GO:0046827

GO:0048156

GO:0048511

GO:0048814

GO:0048856

GO:0050321

GO:0050770

GO:0050877

GO:0051059

GO:0051093

GO:0051128

GO:0060079

GO:0061024

GO:0061629

GO:0065003

GO:0070507

GO:0070885

GO:0071109

GO:0071300

GO:0090090

GO:0097191

GO:0097192

GO:0098793

GO:0098794

GO:0098978

GO:0099171

GO:0106027

GO:0106310

GO:0140096

GO:0150101

GO:1900034

GO:1900181

GO:1900271

GO:1901030

GO:1901984

GO:1902042

GO:1903566

GO:1904339

GO:1904646

GO:1904781

GO:1904886

GO:1905240

GO:1990909

GO:2000077

GO:2000466

GO:2000740

HMNXSV003003003

HMNXSV003009636

Hs.25777.0.A1_3p_at

Hs.90063.1.A1_3p_at

Hs.90063.1.A2_3p_at

ILMN_1779376

L33801_at

PH_hs_0023448

PH_hs_0038609

TC03001688.hg

TC03003047.hg

g12652980_3p_a_at

Participates

as a component of

as an input of

as an output of

Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)

This entity regulates

Positively

B-WICH complex binds rDNA promoter (Homo sapiens)

Other forms of this molecule

GSK3B del304-316 [cytosol]

p-S9-GSK3B [cytosol]

GSK3B [cytosol]

Inferred To

Homologues of GSK3B [nucleoplasm] (Caenorhabditis elegans)

Homologues of GSK3B [nucleoplasm] (Drosophila melanogaster)

GSK3B [nucleoplasm] (Bos taurus)

GSK3B [nucleoplasm] (Caenorhabditis elegans)

GSK3B [nucleoplasm] (Canis familiaris)

GSK3B [nucleoplasm] (Danio rerio)

GSK3B [nucleoplasm] (Drosophila melanogaster)

GSK3B [nucleoplasm] (Gallus gallus)

GSK3B [nucleoplasm] (Rattus norvegicus)

GSK3B [nucleoplasm] (Sus scrofa)

GSK3B [nucleoplasm] (Xenopus tropicalis)

Gsk3b [nucleoplasm] (Mus musculus)

Cross References

RefSeq

NP_002084.2, NP_001139628.1

ZINC - World Drugs

GSK3B_HUMAN

Guide to Pharmacology - Targets

2030

OpenTargets

ENSG00000082701

ZINC - FDA approved

GSK3B_HUMAN

ZINC - Substances

GSK3B_HUMAN

ZINC target

P49841

ZINC - Biogenic

GSK3B_HUMAN

PRO

P49841

PDB

3M1S, 3QKK, 3E87, 1O6L, 4ACC, 1R0E, 4J71, 1J1C, 6GJO, 8DJE, 7U36, 6NPZ, 3SD0, 6H0U, 5KPK, 5F95, 7U33, 3MV5, 4ACH, 3CQW, 3ZRM, 1I09, 1Q41, 4PTG, 1Q4L, 1J1B, 4NM3, 2XH5, 4B7T, 3ZDI, 4NM0, 2OW3, 2X39, 3PUP, 3DU8, 2JLD, 3SAY, 1UV5, 3F88, 6HK7, 2JDO, 5K5N, 3CQU, 1H8F, 5F94, 3E8D, 3GB2, 1PYX, 4AFJ, 6BUU, 3ZRK, 7Z1F, 4PTE, 3Q3B, 3ZRL, 4PTC, 1O9U, 4EKK, 4DIT, 2O5K, 5OY4, 2JDR, 5KPM, 1Q3D, 6B8J, 8DJD, 1O6K, 4IQ6, 4J1R, 6HK4, 4NM7, 7U31, 5HLP, 7U2Z, 4ACG, 4ACD, 3OW4, 7Z1G, 1Q3W, 6V6L, 4NM5, 3I4B, 3E88, 6Y9S, 2UW9, 6Y9R, 3L1S, 1GNG, 1Q5K, 5KPL, 5T31, 8DJC, 7OY5, 7B6F, 6TCU, 6GN1, 6HK3, 3F7Z, 5HLN

ZINC - Investigational

GSK3B_HUMAN

ZINC - Metabolites

GSK3B_HUMAN

IntEnz

2.7.11.26

HPA

ENSG00000082701-GSK3B

GeneCards

P49841

Ensembl

ENSG00000082701, ENSP00000324806, ENST00000316626, ENSP00000264235, ENST00000264235

Pharos - Targets

P49841

Orphanet

29152

ZINC - Predictions - Purchasable

GSK3B_HUMAN

HMDB Protein

HMDBP01162

Interactors (46)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15169 AXIN1	11	AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841)	0.975	51
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.947	19
UniProt:Q9P0R6 GSKIP			0.816	6
UniProt:Q92837 FRAT1	1	FRAT1 [cytosol] (R-HSA-1226051)	0.813	5
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.779	4
UniProt:P25054 APC	20	APC R213* [cytosol] (R-HSA-9666924) APC C1410* [cytosol] (R-HSA-9666925) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930)	0.763	5
UniProt:P17612 PRKACA	3	PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [cytosol] (R-HSA-57844)	0.741	7
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.737	9
UniProt:P13807 GYS1	3	p-S-GYS1 [cytosol] (R-HSA-71570) GYS1 [cytosol] (R-HSA-71565) GYS1 R462* [cytosol] (R-HSA-3828056)	0.73	4
UniProt:P41236 IPP2			0.725	4
UniProt:Q9Y2T1 AXIN2	4	AXIN2 [cytosol] (R-HSA-3640821) RibC-AXIN2 [cytosol] (R-HSA-3640842) Ub-RibC-AXIN2 [cytosol] (R-HSA-3640859) ub-AXIN2 [cytosol] (R-HSA-4641131)	0.725	4
UniProt:P10644 PRKAR1A	4	PRKAR1A(1-183)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713476) PRKAR1A(1-183)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713471) PRKAR1A [ciliary base] (R-HSA-5610408) PRKAR1A [cytosol] (R-HSA-57836)	0.671	4
UniProt:Q96G01 BICD1	1	BICD1 [cytosol] (R-HSA-8848104)	0.671	7
UniProt:Q86TP1 PRUN1			0.671	4
UniProt:Q8N4C6 NIN			0.668	3
UniProt:O35625 Axin1	8	Phospho Axin1 [cytosol] (R-MMU-206175) Axin1 [cytosol] (R-MMU-4641133) phospho-Axin1 [cytosol] (R-MMU-3640864) phospho-Axin1 [cytosol] (R-MMU-3640841) Axin1 [cytosol] (R-MMU-205727) Phospho (3 sites) Axin1 [cytosol] (R-MMU-205737) phospho-Axin1 [cytosol] (R-MMU-206040) Axin1 [cytosol] (R-MMU-195249)	0.659	5
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.658	3
UniProt:P10636 MAPT	3	MAPT(422-758) [cytosol] (R-HSA-350642) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT [cytosol] (R-HSA-201574)	0.656	4
UniProt:O75581 LRP6	8	p-T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-205884) p-S1490-LRP6 [plasma membrane] (R-HSA-206156) LRP6 [early endosome membrane] (R-HSA-5368481) p-LRP6 [early endosome membrane] (R-HSA-5368496) LRP6N [extracellular region] (R-HSA-5334021) p-2S,S1490,2T-LRP6 [plasma membrane] (R-HSA-1458894) p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-1458895) LRP6 [plasma membrane] (R-HSA-206252)	0.656	4
UniProt:Q14596 NBR1	2	NBR1 [peroxisomal membrane] (R-HSA-9665177) NBR1 [cytosol] (R-HSA-9665180)	0.646	4
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.645	7
UniProt:Q9Y2J2 EPB41L3	1	EPB41L3 [cytosol] (R-HSA-6797563)	0.643	3
UniProt:Q02248 Ctnnb1	14	Ctnnb1 [nucleoplasm] (R-MMU-9735212) phospho-Ctnnb1 [nucleoplasm] (R-MMU-3134926) phospho-Ctnnb1 [cytosol] (R-MMU-3134933) Ctnnb1 [cytosol] (R-MMU-202950) Ctnnb1 [nucleoplasm] (R-MMU-3451168) Ctnnb1 [cytosol] (R-MMU-448839) phospho-Ctnnb1 [cytosol] (R-MMU-8942374) beta-catenin [cytosol] (R-MMU-206225) phospho-Ctnnb1 [cytosol] (R-MMU-8942369) phospho-Ctnnb1 [cytosol] (R-MMU-8942367) phospho-Ctnnb1 [cytosol] (R-MMU-8942363) Ctnnb1 [plasma membrane] (R-MMU-9038440) Ctnnb1 [plasma membrane] (R-MMU-9761458) Ctnnb1 [cytosol] (R-MMU-202930)	0.623	3
UniProt:Q811T9 DISC1			0.618	4
UniProt:Q9UKA4 AKA11			0.615	3
UniProt:O95071 UBR5			0.61	8
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.597	3
UniProt:O75952-5 CABYR			0.593	3
UniProt:O75952-3 CABYR			0.593	3
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.59	3
UniProt:Q15797 SMAD1	4	Ub-SMAD1 [cytosol] (R-HSA-6782768) p-S463,S465-SMAD1 [nucleoplasm] (R-HSA-201483) p-S463,S465-SMAD1 [cytosol] (R-HSA-201464) SMAD1 [cytosol] (R-HSA-201468)	0.571	2
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.564	5
UniProt:P05067-PRO_0000000093 APP			0.558	2
UniProt:Q03701 CEBPZ			0.547	2
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.547	2
UniProt:P62879 GNB2	4	GNB2 [cytosol] (R-HSA-6814421) Partially folded GNB2 [cytosol] (R-HSA-8850536) Unfolded GNB2 [cytosol] (R-HSA-6814202) GNB2 [plasma membrane] (R-HSA-164335)	0.547	2
UniProt:Q01201 RELB	2	RELB [nucleoplasm] (R-HSA-5607656) RELB [cytosol] (R-HSA-5607652)	0.544	4
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.544	2
UniProt:Q9NYF0 DACT1	1	DACT1 [cytosol] (R-HSA-4641144)	0.537	3
UniProt:O75122 CLASP2	1	CLASP2 [cytosol] (R-HSA-376252)	0.527	2
UniProt:O75398 DEAF1			0.524	2
UniProt:Q14DJ8 Q14DJ8			0.524	2
UniProt:Q5VWQ8-2 DAB2IP			0.524	2
UniProt:Q8IX07 ZFPM1	1	ZFPM1 [nucleoplasm] (R-HSA-996748)	0.508	2
UniProt:Q6J9G0 STYK1			0.499	2
UniProt:Q8TDD2 SP7	1	SP7 [nucleoplasm] (R-HSA-8939843)	0.463	2

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