HS-GAG biosynthesis

Stable Identifier
R-HSA-2022928
Type
Pathway
Species
Homo sapiens
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Summation

Heparan sulfate (HS) and heparin (sometimes collectively called HS-GAG) consist of the disaccharide unit GlcNAc-GlcA (N-acetylglucosamine-glucuronic acid) connected by a beta1,4 linkage. Heparin is exclusively made in mast cells whereas HS is made by virtually every type of cell in the body. As the chain length increases, the polysaccharides can undergo modifcations such as epimerisation of glucuronic acid to iduronic acid and deacetylation and sulfation of GlcNAc to form sulfated glucosamine (Stringer & Gallagher 1997, Sasisekharan & Venkataraman 2000).

Literature References
PubMed ID Title Journal Year
11102866 Heparin and heparan sulfate: biosynthesis, structure and function

Sasisekharan, R, Venkataraman, G

Curr Opin Chem Biol 2000
9251237 Heparan sulphate

Stringer, SE, Gallagher, JT

Int J Biochem Cell Biol 1997
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Orthologous Events
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