Reactome | LCP2 [cytosol]

LCP2 [cytosol]

Stable Identifier

R-HSA-202306

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SLP-76, Lymphocyte cytosolic protein 2

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External Reference Information

External Reference

UniProt:Q13094 LCP2

Gene Names

LCP2

Chain

chain:1-533

Reference Genes

BioGPS Gene:3937 LCP2

COSMIC (genes):LCP2 LCP2

CTD Gene:3937 LCP2

dbSNP Gene:3937 LCP2

ENSEMBL:ENSG00000043462 LCP2

HGNC:6529 LCP2

KEGG:hsa:3937 LCP2

Monarch:3937 LCP2

NCBI Gene:3937 LCP2

OMIM:601603 LCP2

UCSC:Q13094 LCP2

Reference Transcript

RefSeq:NM_005565.4 LCP2

Other Identifiers

11748120_a_at

17002681

205269_PM_at

205269_at

205270_PM_s_at

205270_s_at

244251_PM_at

244251_at

244556_PM_at

244556_at

244598_PM_at

244598_at

2886593

2886594

2886596

2886597

2886598

2886599

2886601

2886602

2886604

2886605

2886606

2886607

2886611

2886612

2886613

2886614

2886615

2886617

2886619

2886620

2886621

2886622

2886623

2886624

2886625

2886626

2886627

2886629

2886630

2886636

2886637

2886640

2886641

2886642

39319_at

3937

63512_at

79145_at

8115734

89412_at

A_23_P30547

GE79323

GE842618

GO:0002376

GO:0005515

GO:0005737

GO:0005829

GO:0005911

GO:0006955

GO:0007169

GO:0035556

GO:0036398

GO:0044853

GO:0045576

GO:0045860

GO:0050852

HMNXSV003022787

Hs.137314.0.A1_3p_at

Hs.208662.0.A1_3p_at

Hs.304475.0.A1_3p_at

ILMN_1658962

PH_hs_0000333

TC05002050.hg

TC05003348.hg

U20158_at

g7382491_3p_a_at

Participates

as a component of

as an input of

Other forms of this molecule

p-Y113,128,145-LCP2 [cytosol]

Inferred To

Lcp2 [cytosol] (Rattus norvegicus)

SLP-76 [cytosol] (Mus musculus)

Dmel\CG15529 [cytosol] (Drosophila melanogaster)

lcp2 [cytosol] (Xenopus tropicalis)

LCP2 [cytosol] (Bos taurus)

LCP2 [cytosol] (Canis familiaris)

LCP2 [cytosol] (Gallus gallus)

LCP2 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_005556.1

OpenTargets

ENSG00000043462

ENSEMBL

ENSP00000046794, ENST00000046794

HPA

ENSG00000043462-LCP2

PRO

Q13094

Pharos - Targets

Q13094

GlyGen

Q13094

PDB

6ZCJ, 2EAP, 2ROR, 1YWO, 1H3H

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.978	49
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.918	18
UniProt:O15117 FYB	1	FYB [cytosol] (R-HSA-390925)	0.904	11
UniProt:P16333 NCK1	2	NCK1 [plasma membrane] (R-HSA-202992) NCK1 [cytosol] (R-HSA-197954)	0.881	21
UniProt:O89100 Grap2	2	Grap2 [cytosol] (R-MMU-9680624) Grap2 [cytosol] (R-MMU-202367)	0.835	7
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.816	10
UniProt:O75886 STAM2	2	Ub-STAM2 [cytosol] (R-HSA-6782781) STAM2 [cytosol] (R-HSA-182965)	0.788	9
UniProt:P51116 FXR2			0.781	7
UniProt:P15498 VAV1	5	VAV1 [plasma membrane] (R-HSA-1045153) VAV1 [cytosol] (R-HSA-195066) p-Y174-VAV1 [cytosol] (R-HSA-437946) p-Y142,Y160,Y174-VAV1 [plasma membrane] (R-HSA-389323) p-Y-VAV1 [cytosol] (R-HSA-9029087)	0.758	9
UniProt:Q08881 ITK	3	ITK [cytosol] (R-HSA-202319) p-Y512-ITK [cytosol] (R-HSA-422519) p-Y180,Y512-ITK [cytosol] (R-HSA-2685616)	0.734	4
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.718	6
UniProt:P62994 Grb2	3	Grb2 [cytosol] (R-RNO-55929) Grb2 [plasma membrane] (R-RNO-202993) Grb2 [cytosol] (R-RNO-74686)	0.676	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.635	3
UniProt:Q8IVH8 M4K3			0.591	5
UniProt:P08487 PLCG1			0.589	5
UniProt:P06239 LCK	4	LCK [cytosol] (R-HSA-167609) p-Y394-LCK [cytosol] (R-HSA-202308) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [plasma membrane] (R-HSA-8857940)	0.564	2
UniProt:P19174 PLCG1	6	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.564	3
UniProt:Q9H5J4 ELOVL6	1	ELOVL6 [endoplasmic reticulum membrane] (R-HSA-548680)	0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
IntAct:EBI-22313194 CCSB ORF ID			0.556	3
UniProt:Q03526 Itk	4	Itk [cytosol] (R-MMU-3448705) phospho-p-Y180,Y512-ITK [cytosol] (R-MMU-2685616) phospho-p-Y512-ITK [cytosol] (R-MMU-422519) ITK [cytosol] (R-MMU-202319)	0.524	2
UniProt:P30203 CD6			0.499	3

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