Reactome: A Curated Pathway Database

Recruitment of Gads to LAT

Stable Identifier
R-HSA-202325
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Gads is a member of the Grb2 family containing SH2 and SH3 domains with the arrangement SH3-SH2-SH3. Gads binds to the tyrosine phosphorylated residues Y171 and Y191 of LAT through its SH2 domain. It plays a critical role in signaling from the T cell receptor by promoting the formation of a complex between SLP-76 and LAT.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events