Dimerization of FGFR1 point mutants with enhanced kinase activity

Stable Identifier
R-HSA-2023456
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Large scale genomic characterization of glioblastoma tumors has identified three point mutants in the kinase domain of FGFR1: N546K, R576W and K656E (Rand, 2005, TCGA, 2008), representing the first kinase domain point mutants identified in this gene in any cancer. These mutants are believed or have been shown to have enhanced kinase activity and to be able to function in a ligand-independent manner (Petiot, 2002; Lew, 2009; Raffioni, 1998, Rand, 2005; Hart, 2000)

Literature References
PubMed ID Title Journal Year
19224897 The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations

Lew, ED, Furdui, CM, Anderson, KS, Schlessinger, J

Sci Signal 2009
18772890 Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Cancer Genome Atlas Research, Network

Nature 2008
9857065 Effect of transmembrane and kinase domain mutations on fibroblast growth factor receptor 3 chimera signaling in PC12 cells. A model for the control of receptor tyrosine kinase activation

Raffioni, S, Zhu, YZ, Bradshaw, RA, Thompson, LM

J Biol Chem 1998
10918587 Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4

Hart, KC, Robertson, SC, Kanemitsu, MY, Meyer, AN, Tynan, JA, Donoghue, DJ

Oncogene 2000
16186508 Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas

Rand, V, Huang, J, Stockwell, T, Ferriera, S, Buzko, O, Levy, S, Busam, D, Li, K, Edwards, JB, Eberhart, C, Murphy, KM, Tsiamouri, A, Beeson, K, Simpson, AJ, Venter, JC, Riggins, GJ, Strausberg, RL

Proc Natl Acad Sci U S A 2005
12112473 Induction of chondrogenesis in neural crest cells by mutant fibroblast growth factor receptors

Petiot, A, Ferretti, P, Copp, AJ, Chan, CT

Dev Dyn 2002
Participants
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
glioblastoma 3068 spongioblastoma multiforme, Spongioblastoma multiforme, primary glioblastoma multiforme, Glioblastoma multiforme, Glioblastoma (morphologic abnormality), GBM (Glioblastoma), Glioblastoma NOS (morphologic abnormality)
Authored
Reviewed
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