Recruitment of ITK to SLP-76

Stable Identifier
R-HSA-202375
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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ITK is a member of the Tec protein tyrosine kinase family which forms a complex with SLP-76 after TCR activation. ITK has N-terminal pleckstrin homology (PH) domain, a Tec homology (TH) domain, a proline rich domain, a SH3 domain, an SH2 domain and a C-term kinase domain. The SH2 domain of ITK may interact with Y145 within the N-ter acidic domain of SLP-76 and the SH3 domain of the ITK binds the proline rich region of SLP-76. ITK plays an important role in phosphorylating and activating PLC-gamma-1, leading to the development of second-messenger molecules.

Literature References
PubMed ID Title Journal Year
17652306 Keeping the (kinase) party going: SLP-76 and ITK dance to the beat

Qi, Q, August, A

Sci STKE 2007
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created