Reactome: A Curated Pathway Database

Recruitment of ITK to SLP-76

Stable Identifier
R-HSA-202375
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

ITK is a member of the Tec protein tyrosine kinase family which forms a complex with SLP-76 after TCR activation. ITK has N-terminal pleckstrin homology (PH) domain, a Tec homology (TH) domain, a proline rich domain, a SH3 domain, an SH2 domain and a C-term kinase domain. The SH2 domain of ITK may interact with Y145 within the N-ter acidic domain of SLP-76 and the SH3 domain of the ITK binds the proline rich region of SLP-76. ITK plays an important role in phosphorylating and activating PLC-gamma-1, leading to the development of second-messenger molecules.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events