Reactome | PLCH1 [plasma membrane]

PLCH1 [plasma membrane]

Stable Identifier

R-HSA-2023859

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

KIAA1069, PLCL3

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q4KWH8 PLCH1

Gene Names

PLCH1, KIAA1069, PLCL3

Chain

chain:1-1693

Reference Genes

BioGPS Gene:23007 PLCH1

COSMIC (genes):PLCH1 PLCH1

CTD Gene:23007 PLCH1

dbSNP Gene:23007 PLCH1

ENSEMBL:ENSG00000114805 PLCH1

HGNC:29185 PLCH1

KEGG:hsa:23007 PLCH1

Monarch:23007 PLCH1

NCBI Gene:23007 PLCH1

OMIM:612835 PLCH1

UCSC:Q4KWH8 PLCH1

Reference Transcript

Other Identifiers

11728446_a_at

11740464_a_at

16960705

214745_PM_at

214745_at

216633_PM_s_at

216633_s_at

216634_PM_at

216634_at

23007

2701808

2701809

2701817

2701818

2701819

2701820

2701821

2701822

2701823

2701825

2701826

2701827

2701828

2701829

2701830

2701831

2701832

2701833

2701834

2701835

2701837

2701839

2701840

2701841

2701843

2701846

2701849

2701850

2701852

2701855

2701868

2701869

2701879

2701887

2701891

38869_at

8091600

85335_at

A_23_P339240

A_24_P334248

GE723314

GE80579

GO:0003824

GO:0004435

GO:0005509

GO:0005737

GO:0005829

GO:0005886

GO:0006629

GO:0007165

GO:0008081

GO:0016020

GO:0016042

GO:0016787

GO:0035556

GO:0043226

GO:0043231

GO:0046488

GO:0046872

GO:0048015

GO:0050429

GO:0051209

GO:0055085

HMNXSV003019128

Hs.193143.0.S1_3p_a_at

Hs.193143.0.S1_3p_at

Hs.193143.0.S1_3p_x_at

Hs.193143.1.S1_3p_at

ILMN_2043060

PH_hs_0032093

TC03001926.hg

TC03003170.hg

Participates

as a component of

PLCH1:Ca2+ [plasma membrane] (Homo sapiens)

Inferred To

Plch1 [plasma membrane] (Rattus norvegicus)

PLCH1 [plasma membrane] (Bos taurus)

PLCH1 [plasma membrane] (Canis familiaris)

PLCH1 [plasma membrane] (Dictyostelium discoideum)

PLCH1 [plasma membrane] (Gallus gallus)

PLCH1 [plasma membrane] (Mus musculus)

PLCH1 [plasma membrane] (Plasmodium falciparum)

PLCH1 [plasma membrane] (Saccharomyces cerevisiae)

PLCH1 [plasma membrane] (Schizosaccharomyces pombe)

PLCH1 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_001124432.1, NP_001124433.1, XP_016861418.1, NP_055811.1

Guide to Pharmacology - Targets

1414

ENSEMBL

ENSP00000419100, ENSP00000402759, ENSP00000345988, ENSP00000335469, ENST00000447496, ENST00000494598, ENST00000340059, ENST00000334686

OpenTargets

ENSG00000114805

IntEnz

3.1.4.11

HPA

ENSG00000114805-PLCH1

PRO

Q4KWH8

Pharos - Targets

Q4KWH8

GlyGen

Q4KWH8

HMDB Protein

HMDBP04455

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.706	4
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.615	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.483	3

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