Translocation of CARMA1 to Plasma membrane

Stable Identifier
R-HSA-202394
Type
Reaction
Species
Homo sapiens
Compartment
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CARMA1 and Bcl10 are the possible link between PKC theta and IKK activation. PDK1 is also required for PKC theta mediated activation of IKK. CARMA1 has a N-terminal CARD motif, a coiled coiled region, a linker region, and a MAGUK-typical PDZ, SH3 and a GUK domains. The linker region is proposed to contain a hinge region and a CARD binding domain. CARMA1 exists in an inactive conformation in which the linker region binds to and blocks the accessibility of the CARD motif. CARMA1 is recruited to the plasma membrane by binding to the 'PxxP' motif of membrane bound PDK1 with its SH3 domain.

Literature References
PubMed ID Title Journal Year
17468049 Post-translational modifications regulate distinct functions of CARMA1 and BCL10

Thome, M, Weil, R

Trends Immunol 2007
15541657 The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling

Lin, X, Wang, D

Semin Immunol 2004
15122200 CARMA1, BCL-10 and MALT1 in lymphocyte development and activation

Thome, M

Nat Rev Immunol 2004
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