TCR signaling

Stable Identifier
R-HSA-202403
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

The TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen presenting cells (APCs) results in the activation of protein tyrosine kinases (PTKs) that associate with CD3 and TCR zeta subunits and the co-receptor CD4. Members of the Src kinases (Lck), Syk kinases (ZAP-70), Tec (Itk) and Csk families of nonreceptor PTKs play a crucial role in T cell activation. Activation of PTKs following TCR engagement results in the recruitment and tyrosine phosphorylation of enzymes such as phospholipase C gamma1 and Vav as well as critical adaptor proteins such as LAT, SLP-76 and Gads. These proximal activation leads to reorganization of the cytoskeleton as well as transcription activation of multiple genes leading to T lymphocyte proliferation, differentiation and/or effector function.

Literature References
PubMed ID Title Journal Year
12876557 Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling

Rudd, CE, Schneider, H

Nat Rev Immunol 2003
10375551 T cell antigen-receptor signal transduction

van Leeuwen, JE, Samelson, LE

Curr Opin Immunol 1999
9989491 Adaptors and molecular scaffolds in immune cell signaling

Rudd, CE

Cell 1999
Participants
Participant Of
Event Information
Orthologous Events
Authored
Reviewed
Created