TCR signaling

Stable Identifier
R-HSA-202403
Type
Pathway
Species
Homo sapiens
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The TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen presenting cells (APCs) results in the activation of protein tyrosine kinases (PTKs) that associate with CD3 and TCR zeta subunits and the co-receptor CD4. Members of the Src kinases (Lck), Syk kinases (ZAP-70), Tec (Itk) and Csk families of nonreceptor PTKs play a crucial role in T cell activation. Activation of PTKs following TCR engagement results in the recruitment and tyrosine phosphorylation of enzymes such as phospholipase C gamma1 and Vav as well as critical adaptor proteins such as LAT, SLP-76 and Gads. These proximal activation leads to reorganization of the cytoskeleton as well as transcription activation of multiple genes leading to T lymphocyte proliferation, differentiation and/or effector function.

Literature References
PubMed ID Title Journal Year
9989491 Adaptors and molecular scaffolds in immune cell signaling

Rudd, CE

Cell 1999
10375551 T cell antigen-receptor signal transduction

van Leeuwen, JE, Samelson, LE

Curr Opin Immunol 1999
12876557 Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling

Schneider, H, Rudd, CE

Nat Rev Immunol 2003
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Orthologous Events
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