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PLC-gamma1 hydrolyses PIP2

Stable Identifier
R-HSA-202407
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

On recruitment to plasma membrane PLC-gamma1 then hydrolyses PIP2 producing two second messengers, diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). IP3 induces a transient increase in intracellular free Ca++, while DAG is a direct activator of protein kinase C (PKC theta). These process have been implicated in many cellular physiological functions like cell proliferation, cell growth and differentiation.

Literature References
PubMed ID Title Journal Year
11048639 The mechanism of phospholipase C-gamma1 regulation Exp Mol Med 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol phospholipase C activity of Activated PLC gamma1 bound to PIP2 [plasma membrane]
Physical Entity
Activity
Orthologous Events