HS-GAGs translocate to the lysosome for degradation

Stable Identifier
R-HSA-2024084
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane, lysosomal lumen
ReviewStatus
5/5
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HS-GAGs translocate to the lysosome for degradation
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As part of the natural turnover of GAGs, extracellular HSPGs are endocytosed to the lysosome to be degraded (Winchester 2005).
Literature References
PubMed ID Title Journal Year
15647514 Lysosomal metabolism of glycoproteins

Winchester, B

Glycobiology 2005
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
endocytosis (0006897)
Orthologous Events
HS-GAGs translocate to the lysosome for degradation (Bos taurus)
HS-GAGs translocate to the lysosome for degradation (Caenorhabditis elegans)
HS-GAGs translocate to the lysosome for degradation (Canis familiaris)
HS-GAGs translocate to the lysosome for degradation (Danio rerio)
HS-GAGs translocate to the lysosome for degradation (Drosophila melanogaster)
HS-GAGs translocate to the lysosome for degradation (Gallus gallus)
HS-GAGs translocate to the lysosome for degradation (Mus musculus)
HS-GAGs translocate to the lysosome for degradation (Rattus norvegicus)
HS-GAGs translocate to the lysosome for degradation (Sus scrofa)
HS-GAGs translocate to the lysosome for degradation (Xenopus tropicalis)
Authored
Jassal, B  (2011-12-14)
Reviewed
Hill, DP  (2022-05-20)
D'Eustachio, P  (2012-03-28)
Created
Jassal, B  (2011-12-14)
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