HS-GAG degradation

Stable Identifier
R-HSA-2024096
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

Lysosomal degradation of glycoproteins is part of the cellular homeostasis of glycosylation (Winchester 2005). The steps outlined below describe the degradation of heparan sulfate/heparin. Complete degradation of glycoproteins is required to avoid build up of glycosaminoglycan fragments which can cause lysosomal storage diseases. The proteolysis of the core protein of the glycoprotein is not shown here.

Literature References
PubMed ID Title Journal Year
15647514 Lysosomal metabolism of glycoproteins

Winchester, B

Glycobiology 2005
Participants
Participant Of
Event Information
Orthologous Events
Authored
Reviewed
Created