Interaction of Bcl10 to CARMA1

Stable Identifier
R-HSA-202466
Type
Reaction
Species
Homo sapiens
Compartment
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Bcl10 is recruited to activated, oligomeric CARMA1 through a CARD-CARD interaction. Bcl10 is characterized by an N-terminal CARD motif and a C-terminal extension of ~130 amino acids rich in serine and threonine residues that serve as targets for multiple phosphorylation events.

Literature References
PubMed ID Title Journal Year
15122200 CARMA1, BCL-10 and MALT1 in lymphocyte development and activation

Thome, M

Nat Rev Immunol 2004
17468049 Post-translational modifications regulate distinct functions of CARMA1 and BCL10

Thome, M, Weil, R

Trends Immunol 2007
Participants
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Orthologous Events
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