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p-BCL10 [cytosol]
Stable Identifier
R-HSA-202488
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
phosphorylated Bcl10
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Activation of NF-kappaB in B cells (Homo sapiens)
CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Homo sapiens)
p-BCL10 [cytosol] (Homo sapiens)
p-CARMA1:MALT1:p-BCL10 [plasma membrane] (Homo sapiens)
p-BCL10 [cytosol] (Homo sapiens)
CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK (Homo sapiens)
p-CARMA1:MALT1:p-BCL10 [plasma membrane] (Homo sapiens)
p-BCL10 [cytosol] (Homo sapiens)
p-CARMA1:MALT1:p-BCL10:TAK1:IKK [plasma membrane] (Homo sapiens)
p-CARMA1:MALT1:p-BCL10 [plasma membrane] (Homo sapiens)
p-BCL10 [cytosol] (Homo sapiens)
TAK1 associated with the CBM complex phosphorylates IKKbeta (Homo sapiens)
p-CARMA1:MALT1:p-BCL10:TAK1 [plasma membrane] (Homo sapiens)
p-CARMA1:MALT1:p-BCL10 [plasma membrane] (Homo sapiens)
p-BCL10 [cytosol] (Homo sapiens)
p-CARMA1:MALT1:p-BCL10:TAK1:IKK [plasma membrane] (Homo sapiens)
p-CARMA1:MALT1:p-BCL10 [plasma membrane] (Homo sapiens)
p-BCL10 [cytosol] (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
Activation of IKK complex (Homo sapiens)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Homo sapiens)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
p-BCL10 [cytosol] (Homo sapiens)
Activation of TAK1-TAB2 complex (Homo sapiens)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Homo sapiens)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
p-BCL10 [cytosol] (Homo sapiens)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
p-BCL10 [cytosol] (Homo sapiens)
Auto-ubiquitination of TRAF6 (Homo sapiens)
TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
p-BCL10 [cytosol] (Homo sapiens)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
p-BCL10 [cytosol] (Homo sapiens)
Interaction and oligomerization of MALT1 to Bcl10 (Homo sapiens)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
p-BCL10 [cytosol] (Homo sapiens)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
p-BCL10 [cytosol] (Homo sapiens)
Oligomerization of Bcl10 (Homo sapiens)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
p-BCL10 [cytosol] (Homo sapiens)
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Homo sapiens)
p-BCL10 [cytosol] (Homo sapiens)
p-BCL10 [cytosol] (Homo sapiens)
Phosphorylation of Bcl10 (Homo sapiens)
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Homo sapiens)
p-BCL10 [cytosol] (Homo sapiens)
Translocation of TRAF6 to CBM complex (Homo sapiens)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
p-BCL10 [cytosol] (Homo sapiens)
TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
p-BCL10 [cytosol] (Homo sapiens)
Ubiquitination of NEMO by TRAF6 (Homo sapiens)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
p-BCL10 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
Ubiquitination of NEMO by TRAF6 (Homo sapiens)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
p-BCL10 [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated NF-kB activation (Homo sapiens)
Ubiquitination of NEMO by TRAF6 (Homo sapiens)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Homo sapiens)
p-BCL10 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95999 BCL10
Gene Names
BCL10, CIPER, CLAP
Chain
chain:1-233
Reference Genes
BioGPS Gene:8915 BCL10
COSMIC (genes):BCL10 BCL10
CTD Gene:8915 BCL10
dbSNP Gene:8915 BCL10
ENSEMBL:ENSG00000142867 BCL10
HGNC:989 BCL10
KEGG Gene (Homo sapiens):8915 BCL10
Monarch:8915 BCL10
NCBI Gene:8915 BCL10
OMIM:603517 BCL10
UCSC:O95999 BCL10
Reference Transcript
RefSeq:NM_003921.4 BCL10
Other Identifiers
0001780504
11726703_a_at
11726704_x_at
11753497_a_at
16689060
205263_at
2420809
2420810
2420811
2420812
2420815
2420816
2420817
2420823
2420824
2420825
2420826
2MB9
38871_at
6BZE
6GK2
74831_r_at
7917338
8915
89594_f_at
A0A087WWW9
A0A3B3ISX2
A_23_P115286
A_24_P19983
A_33_P3392447
AAC99767
AAD15800
AAD16428
AAD24918
AAD32597
AAD39147
AAF06894
AAH53617
AF057700
AF082283
AF097732
AF100338
AF105066
AF127386
AF134395
AJ006288
AK291346
AL590113
BAF84035
BC053617
BCL10
BCL10-202
CAA06955
CAB001944
CCDS704
CH471097
EAW73208
ENSG00000142867
ENSP00000498104
ENST00000648566
ENST00000648566.1
EntrezGene:8915
EntrezGene:BCL10
g4092066_3p_at
GE79818
GO:0001772
GO:0001783
GO:0001843
GO:0002020
GO:0002223
GO:0002224
GO:0002237
GO:0002250
GO:0002376
GO:0002906
GO:0003674
GO:0003713
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005764
GO:0005773
GO:0005829
GO:0005856
GO:0005881
GO:0005886
GO:0006464
GO:0006915
GO:0006950
GO:0006968
GO:0007155
GO:0007165
GO:0007249
GO:0008022
GO:0008134
GO:0008150
GO:0008219
GO:0009058
GO:0009620
GO:0009790
GO:0016020
GO:0016064
GO:0016567
GO:0019209
GO:0019899
GO:0019900
GO:0019901
GO:0022607
GO:0030234
GO:0031398
GO:0031625
GO:0031663
GO:0032094
GO:0032449
GO:0032765
GO:0032991
GO:0033674
GO:0034641
GO:0038095
GO:0042109
GO:0042226
GO:0042327
GO:0042592
GO:0042802
GO:0042981
GO:0043065
GO:0043123
GO:0043226
GO:0043280
GO:0043422
GO:0043621
GO:0045087
GO:0045121
GO:0045416
GO:0045893
GO:0048471
GO:0048646
GO:0048856
GO:0050700
GO:0050852
GO:0050856
GO:0050870
GO:0051059
GO:0051092
GO:0051259
GO:0051260
GO:0051291
GO:0065003
GO:0070231
GO:0071260
GO:2001238
HGNC:989
HPA017925
ILMN_1676874
ILMN_1716446
IPR001315
IPR011029
IPR033238
LRG_1210
MIM:137245
MIM:156240
MIM:273300
MIM:603517
MIM:605027
MIM:616098
NM_003921
NP_003912
PF00619
PH_hs_0011415
TC01002828.hg
UPI000012682F
Participant Of
input
CARMA1 recruits MALT1 and BCL10 forming CBM Complex
Oligomerization of Bcl10
hasComponent
Bcl10 trimer bound to CARMA1 trimer [plasma membrane]
p-CARMA1:MALT1:p-BCL10 [plasma membrane]
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane]
Other forms of this molecule
K48polyUb-BCL10 [cytosol]
BCL10 [cytosol]
Inferred To
Ghost homologue of p-BCL10 [cytosol] (Danio rerio)
phospho-p-BCL10 [cytosol] (Bos taurus)
phospho-p-BCL10 [cytosol] (Canis familiaris)
phospho-p-BCL10 [cytosol] (Gallus gallus)
phospho-p-BCL10 [cytosol] (Mus musculus)
phospho-p-BCL10 [cytosol] (Rattus norvegicus)
phospho-p-BCL10 [cytosol] (Sus scrofa)
phospho-p-BCL10 [cytosol] (Xenopus tropicalis)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Cross References
RefSeq
NP_003912.1
OpenTargets
ENSG00000142867
GeneCards
O95999
PRO
O95999
Orphanet
23652
PDB
6BZE
,
6GK2
,
2MB9
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UDY8 MALT1
1
MALT1 [cytosol]
(R-HSA-202461)
0.914
18
UniProt:Q9BXL7 CARD11
5
p-S552,S645-CARD11 [cytosol]
(R-HSA-2685625)
CARD11 [plasma membrane]
(R-HSA-2685592)
CARD11 [cytosol]
(R-HSA-202161)
p-S552-CARD11 [cytosol]
(R-HSA-202438)
p-S559,S644,S652-CARD11 [plasma membrane]
(R-HSA-1168564)
0.857
7
UniProt:Q12933 TRAF2
5
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
TRAF2 [cytosol]
(R-HSA-66370)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
0.795
8
UniProt:Q9Y6K9 IKBKG
12
IKBKG [nucleoplasm]
(R-HSA-4755413)
SUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wro*447 [cytosol]
(R-HSA-5262978)
IKBKG [cytosol]
(R-HSA-168108)
K63polyUb-NEMO [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
0.789
7
UniProt:O95999 BCL10
3
BCL10 [cytosol]
(R-HSA-202447)
K48polyUb-BCL10 [cytosol]
(R-HSA-8939329)
p-BCL10 [cytosol]
(R-HSA-202488)
0.721
4
IntAct:EBI-4399559 UBIQ
0.704
5
UniProt:P31749 AKT1
13
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
0.69
5
UniProt:Q9Y2V7 COG6
2
COG6 [Golgi membrane]
(R-HSA-2980958)
COG6 [trans-Golgi network membrane]
(R-HSA-6813872)
0.666
4
UniProt:Q96LW7 CAR19
0.602
4
UniProt:Q05513 PRKCZ
5
p-T410,T563-PRKCZ [cytosol]
(R-HSA-5218698)
p-T410-PRKCZ [cytosol]
(R-HSA-437181)
PRKCZ [cytosol]
(R-HSA-58218)
pS, p-T410-PRKCZ [cytosol]
(R-HSA-9632824)
PRKCZ [cell junction]
(R-HSA-2134483)
0.556
3
UniProt:Q9H257 CARD9
3
CARD9 [cytosol]
(R-HSA-561194)
p-T231-CARD9 [plasma membrane]
(R-HSA-5607623)
CARD9 [plasma membrane]
(R-HSA-5607662)
0.547
6
UniProt:P20749 BCL3
0.524
3
UniProt:Q66677 VCLAP
0.508
2
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