Reactome | p-T184,T187-MAP3K7 [cytosol]

p-T184,T187-MAP3K7 [cytosol]

Stable Identifier

R-HSA-202527

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-T184,187-TAK1

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O43318 MAP3K7

Gene Names

MAP3K7, TAK1

Chain

chain:1-606

Reference Genes

BioGPS Gene:6885 MAP3K7

COSMIC (genes):MAP3K7 MAP3K7

CTD Gene:6885 MAP3K7

dbSNP Gene:6885 MAP3K7

ENSEMBL:ENSG00000135341 MAP3K7

HGNC:6859 MAP3K7

KEGG:hsa:6885 MAP3K7

Monarch:6885 MAP3K7

NCBI Gene:6885 MAP3K7

OMIM:602614 MAP3K7

UCSC:O43318 MAP3K7

Reference Transcript

Participates

as a component of

Other forms of this molecule

MAP3K7 [cytosol]

p-T184,T187-MAP3K7 [endosome membrane]

MAP3K7 [endosome membrane]

p-T187-MAP3K7 [cytosol]

p-MAP3K7 [cytosol]

K63polyUb-34,158-TAK1 [cytosol]

K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol]

MAP3K7 [plasma membrane]

PolyUb-MAP3K7 [cytosol]

Inferred To

phospho-p-T184,T187-MAP3K7 [cytosol] (Bos taurus)

phospho-p-T184,T187-MAP3K7 [cytosol] (Drosophila melanogaster)

phospho-p-T184,T187-MAP3K7 [cytosol] (Gallus gallus)

phospho-p-T184,T187-MAP3K7 [cytosol] (Mus musculus)

phospho-p-T184,T187-MAP3K7 [cytosol] (Rattus norvegicus)

phospho-p-T184,T187-MAP3K7 [cytosol] (Sus scrofa)

phospho-p-T184,T187-MAP3K7 [cytosol] (Xenopus tropicalis)

phospho-MAP3K7 [cytosol] (Canis familiaris)

Modified Residues

Name

O-phospho-L-threonine at 184

Coordinate

184

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 187

Coordinate

187

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_663305.1, NP_663306.1, NP_663304.1, NP_003179.1

Guide to Pharmacology - Targets

2082

OpenTargets

ENSG00000135341

ENSEMBL

ENSP00000358331, ENSP00000515074, ENSP00000358333, ENST00000369332, ENST00000369325, ENST00000700580, ENSG00000135341, ENSP00000358335, ENST00000369327, ENST00000369329, ENSP00000358338

ZINC - FDA approved

M3K7_HUMAN

ZINC - Substances

M3K7_HUMAN

ZINC - Biogenic

M3K7_HUMAN

ZINC target

O43318

PRO

O43318

GlyGen

O43318

PDB

4O91, 5JH6, 5JGD, 7NTH, 5J9L, 5JGB, 5J7S, 4L53, 5GJG, 5JGA, 2EVA, 5JK3, 7NTI, 4GS6, 5J8I, 4L3P, 5GJD, 4L52, 5V5N, 5E7R, 8GW3, 2YIY, 5GJF

ZINC - Investigational

M3K7_HUMAN

GeneCards

MAP3K7

HPA

ENSG00000135341-MAP3K7

Pharos - Targets

O43318

Orphanet

MAP3K7

ZINC - Predictions - Purchasable

M3K7_HUMAN

HMDB Protein

HMDBP01334

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NYJ8 TAB2	4	TAB2 [cytosol] (R-HSA-168117) TAB2 [endosome membrane] (R-HSA-450279) TAB2 [plasma membrane] (R-HSA-168116) TAB2 [nucleoplasm] (R-HSA-1253323)	0.91	8
UniProt:Q15750 TAB1	6	TAB1 [cytosol] (R-HSA-167923) TAB1 [endosome membrane] (R-HSA-450238) TAB1(1-444) [cytosol] (R-HSA-9729751) TAB1(1-132) [cytosol] (R-HSA-9729698) TAB1(133-504) [cytosol] (R-HSA-9729724) TAB1(445-504) [cytosol] (R-HSA-9729691)	0.899	10
UniProt:Q8N5C8 TAB3	3	TAB3 [plasma membrane] (R-HSA-446879) TAB3 [endosome membrane] (R-HSA-450247) TAB3 [cytosol] (R-HSA-450264)	0.773	5
UniProt:Q9UQF2 JIP1			0.723	11
UniProt:O14733 MAP2K7	4	p-S271,T275-MAP2K7 [cytosol] (R-HSA-450353) MAP2K7 [cytosol] (R-HSA-450276) MAP2K7(2-?) [cytosol] (R-HSA-5211389) MAP2K7(?-419) [cytosol] (R-HSA-5211401)	0.674	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.669	4
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.669	3
UniProt:O14920 IKBKB	3	IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518)	0.657	6
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.656	4
UniProt:O15111 CHUK	4	CHUK [cytosol] (R-HSA-168104) p-S176,S180-CHUK [cytosol] (R-HSA-177667) p-T23-CHUK [cytosol] (R-HSA-198615) p-Y187,Y198-CHUK [cytosol] (R-HSA-9861501)	0.65	3
UniProt:O00743 PPP6C	2	PPP6C [cytosol] (R-HSA-5685719) PPP6C [nucleoplasm] (R-HSA-9686576)	0.602	4
UniProt:B5Z6S0 B5Z6S0			0.602	4
UniProt:Q9UBE8 NLK	3	NLK [cytosol] (R-HSA-4411330) p-T298-NLK [cytosol] (R-HSA-4411398) p-T298-NLK [nucleoplasm] (R-HSA-4411376)	0.569	3
UniProt:P40763 STAT3	12	p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-STAT3 [cytosol] (R-HSA-8982823) p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811)	0.558	4
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.556	4
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.527	2
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.527	3
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.527	2
UniProt:Q9UKE5 TNIK	1	TNIK [cytosol] (R-HSA-3214889)	0.499	3
UniProt:P15311 EZR	3	p-Y146,Y354-EZR [cytosol] (R-HSA-374572) p-T567-EZR [cytosol] (R-HSA-374559) EZR [cytosol] (R-HSA-9020826)	0.483	2

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