Reactome | K63polyUb-IKBKG [cytosol]

K63polyUb-IKBKG [cytosol]

Stable Identifier

R-HSA-202530

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

K63polyUb-NEMO

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Literature References

PubMed ID	Title	Journal	Year
17728323	Identification of TRAF6-dependent NEMO polyubiquitination sites through analysis of a new NEMO mutation causing incontinentia pigmenti Sebban-Benin, H, Pescatore, A, Courtois, G, Fusco, F, Ursini, MV, Yamaoka, S, Gautheron, J, Pascuale, V, Moncla, A	Hum Mol Genet	2007

External Reference Information

External Reference

UniProt:Q9Y6K9 IKBKG

Gene Names

IKBKG, FIP3, NEMO

Chain

chain:1-419

Reference Genes

BioGPS Gene:8517 IKBKG

COSMIC (genes):IKBKG IKBKG

CTD Gene:8517 IKBKG

dbSNP Gene:8517 IKBKG

ENSEMBL:ENSG00000269335 IKBKG

HGNC:5961 IKBKG

KEGG:hsa:8517 IKBKG

Monarch:8517 IKBKG

NCBI Gene:8517 IKBKG

OMIM:300248 IKBKG

UCSC:Q9Y6K9 IKBKG

Reference Transcript

Other Identifiers

11755328_a_at

11755329_x_at

11756119_a_at

11756120_x_at

11756123_a_at

11756124_x_at

11756384_a_at

11756385_x_at

17108468

209929_PM_s_at

209929_s_at

36004_3p_at

36004_PM_at

36004_at

3996552

3996553

3996554

3996556

3996557

3996558

3996559

3996560

3996561

3996562

3996563

3996564

3996565

3996566

3996567

3996569

3996570

3996572

3996573

3996574

3996575

3996576

3996577

3996578

3996579

3996580

3996581

3996582

3996583

3996584

3996585

3996586

3996587

3996588

3996589

3996590

4027476

4027477

4027478

4027479

4027480

4027481

4027482

4027483

4027484

4027485

4027486

4027487

4027488

4027489

4027490

4027492

4027494

4027533

4027574

8170955

8517

A_14_P109815

A_23_P159920

GE54691

GO:0000151

GO:0000922

GO:0002376

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006355

GO:0006915

GO:0006954

GO:0006955

GO:0006974

GO:0007249

GO:0008385

GO:0009615

GO:0012501

GO:0016239

GO:0016301

GO:0016740

GO:0019904

GO:0031593

GO:0031625

GO:0032991

GO:0035591

GO:0042742

GO:0042802

GO:0042803

GO:0043123

GO:0043226

GO:0043276

GO:0045087

GO:0045944

GO:0046872

GO:0046982

GO:0050852

GO:0050862

GO:0051092

GO:0051650

GO:0060090

GO:0065003

GO:0070530

GO:0072686

GO:0098542

GO:1990450

GO:1990459

GO:2000060

HMNXSV003001956

HMNXSV003012514

ILMN_1707308

PH_hs_0027638

TC0X001541.hg

TC0X001941.hg

g5031140_3p_s_at

Participates

as a member of

K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Homo sapiens)

as a component of

CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Homo sapiens)

Other forms of this molecule

IKBKG [cytosol]

Ub-285-IKBKG [cytosol]

IKBKG [nucleoplasm]

monoSUMO1-K277,K309-IKBKG [nucleoplasm]

IKBKG *420Wext*447 [cytosol]

IKBKG R175P [cytosol]

IKBKG R173G [cytosol]

IKBKG C417R [cytosol]

IKBKG E391* [cytosol]

IKBKG L153R [cytosol]

IKBKG D406V [cytosol]

Inferred To

Ikbkg [cytosol] (Rattus norvegicus)

K63polyUb-IKBKG [cytosol] (Bos taurus)

K63polyUb-IKBKG [cytosol] (Drosophila melanogaster)

K63polyUb-IKBKG [cytosol] (Mus musculus)

K63polyUb-IKBKG [cytosol] (Rattus norvegicus)

K63polyUb-IKBKG [cytosol] (Sus scrofa)

IKBKG [cytosol] (Canis familiaris)

Homologues of K63polyUb-IKBKG [cytosol] (Rattus norvegicus)

ikbkg [cytosol] (Danio rerio)

Modified Residues

Name

ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 321

Coordinate

321

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 325

Coordinate

325

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 326

Coordinate

326

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at unknown position

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001308325.1, NP_003630.1, NP_001308326.1, NP_001093327.1, NP_001138727.1, NP_001093326.2

OpenTargets

ENSG00000269335

ENSEMBL

ENST00000618670, ENSP00000478616, ENSP00000395205, ENSP00000394934, ENSP00000471166, ENSP00000390368, ENST00000594239, ENST00000440286, ENST00000422680, ENST00000445622, ENST00000611176, ENSP00000479662, ENST00000611071, ENSP00000483825

HPA

ENSG00000269335-IKBKG

ZINC - Substances

NEMO_HUMAN

ZINC target

Q9Y6K9

PRO

Q9Y6K9

Pharos - Targets

Q9Y6K9

GlyGen

Q9Y6K9

Orphanet

IKBKG

ZINC - Predictions - Purchasable

NEMO_HUMAN

PDB

6MI4, 6MI3, 7T2U, 6YEK, 5AAY, 4BWN, 3BRT, 3FX0, 5LDE, 3BRV, 3CL3, 7TV4, 6XX0, 2JVX, 2JVY

Interactors (73)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14920 IKBKB	3	IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518)	0.982	40
UniProt:O15111 CHUK	4	CHUK [cytosol] (R-HSA-168104) p-S176,S180-CHUK [cytosol] (R-HSA-177667) p-T23-CHUK [cytosol] (R-HSA-198615) p-Y187,Y198-CHUK [cytosol] (R-HSA-9861501)	0.972	31
UniProt:Q13546 RIPK1	20	RIPK1 [cytosol] (R-HSA-168651) RIPK1 [endosome membrane] (R-HSA-450326) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) p-S166-RIPK1 [cytosol] (R-HSA-5218872) p-S357-RIPK1 [cytosol] (R-HSA-9819116) p-S320-RIPK1 [cytosol] (R-HSA-9815498) K63,M1polyUb, p-T189-RIPK1 [cytosol] (R-HSA-9817377) polyUb-K377,K604,K634-RIPK1 [cytosol] (R-HSA-9818391) RIPK1(325-671) [cytosol] (R-HSA-5212671) RIPK1(1-324) [cytosol] (R-HSA-5212664) K63,M1polyUb-RIPK1 [cytosol] (R-HSA-9793681) K63,Met1polyUb-p-S25-RIPK1 [cytosol] (R-HSA-9818793) K48polyUb-K571,K604,K627-RIPK1 [cytosol] (R-HSA-9796639) RIPK1 [plasma membrane] (R-HSA-937073) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324N [cytosol] (R-HSA-9693930) PolyUb-RIPK1 [cytosol] (R-HSA-6783197) K48polyUb-RIPK1 [cytosol] (R-HSA-6783308)	0.893	9
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.878	10
UniProt:Q9BYM8 RBCK1	1	RBCK1 [cytosol] (R-HSA-976018)	0.858	9
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.848	9
UniProt:P25963 NFKBIA	9	NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805) PolyUb-NFKBIA [cytosol] (R-HSA-6782960)	0.845	6
IntAct:EBI-4399559 UBIQ			0.829	8
UniProt:Q9H0F6 SHARPIN	1	SHARPIN [cytosol] (R-HSA-5212666)	0.818	14
UniProt:P21580 TNFAIP3	1	TNFAIP3 [cytosol] (R-HSA-688989)	0.813	6
UniProt:O95999 BCL10	3	K48polyUb-BCL10 [cytosol] (R-HSA-8939329) BCL10 [cytosol] (R-HSA-202447) p-BCL10 [cytosol] (R-HSA-202488)	0.789	7
UniProt:Q96EP0 RNF31	1	RNF31 [cytosol] (R-HSA-5212660)	0.773	10
UniProt:Q9UHD2 TBK1	5	p-S172-TBK1 [cytosol] (R-HSA-168379) TBK1 [cytosol] (R-HSA-166267) K63polyUb-K30,K401-TBK1 [cytosol] (R-HSA-9730430) p-TBK1 [cytosol] (R-HSA-9008705) pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397)	0.77	5
UniProt:Q8NFZ5 TNIP2	1	TNIP2 [cytosol] (R-HSA-451661)	0.764	8
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.75	4
UniProt:Q99558 MAP3K14	5	Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187) K48polyUb-NIK [cytosol] (R-HSA-5668525) p-T559-MAP3K14 [cytosol] (R-HSA-5668531)	0.744	5
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.744	5
UniProt:Q15025 TNIP1	1	TNIP1 [cytosol] (R-HSA-5690853)	0.709	6
IntAct:EBI-15701099 IKKALPHA/BETA			0.695	6
UniProt:P01375 TNF	5	TNF(1-233) [plasma membrane] (R-HSA-66220) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(52-76) [extracellular region] (R-HSA-8863375)	0.669	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.669	4
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.666	4
UniProt:Q92844 TANK	2	K63polyUb-TANK [cytosol] (R-HSA-5362480) TANK [cytosol] (R-HSA-933407)	0.659	6
UniProt:Q9UDY8 MALT1	1	MALT1 [cytosol] (R-HSA-202461)	0.656	4
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.643	4
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.641	4
UniProt:P24941 CDK2	5	p-T160-CDK2 [nucleoplasm] (R-HSA-187967) CDK2 [nucleoplasm] (R-HSA-68365) CDK2 [cytosol] (R-HSA-157440) p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905)	0.633	4
UniProt:Q14161 GIT2	1	GIT2 [cytosol] (R-HSA-446034)	0.618	6
UniProt:Q8VSC3 IPA9			0.616	8
UniProt:P19838 NFKB1	8	3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) NFKB1(1-968) [cytosol] (R-HSA-451607) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004)	0.615	3
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.609	2
UniProt:P24772 PG200			0.597	3
UniProt:Q9HC62 SENP2	1	SENP2 [nucleoplasm] (R-HSA-2984298)	0.581	3
UniProt:P21579 SYT1	7	SYT1 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-372508) SYT1 [plasma membrane] (R-HSA-168786) SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917741) SYT1 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-372514) SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane] (R-HSA-210536) SYT1 [synaptic vesicle membrane] (R-HSA-194789) SYT1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869113)	0.581	3
UniProt:Q9UBF6 RNF7	1	RNF7 (RBX2) [cytosol] (R-HSA-8863132)	0.581	3
UniProt:P05937 CALB1	1	CALB1 [cytosol] (R-HSA-2980899)	0.581	3
UniProt:P05783 KRT18	1	KRT18 [cytosol] (R-HSA-201582)	0.57	3
UniProt:P63261 ACTG1	3	ACTG1 [plasma membrane] (R-HSA-196044) ACTG1 [lysosomal membrane] (R-HSA-196169) ACTG1 [cytosol] (R-HSA-201858)	0.564	2
UniProt:Q15653 NFKBIB	3	p-S19,S23-Ub-NFKBIB [cytosol] (R-HSA-1168571) p-S19,S23-NFKBIB [cytosol] (R-HSA-177670) NFKBIB [cytosol] (R-HSA-168132)	0.564	2
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.564	3
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.564	2
UniProt:Q9H0I2 ENKD1			0.556	3
UniProt:Q04712 RRN11			0.556	3
UniProt:P0DTD1-PRO_0000449631 REP			0.556	3
UniProt:Q96PV6 LENG8			0.556	3
UniProt:Q7Z4H3 HDDC2			0.556	3
UniProt:Q96SQ5 ZNF587	1	ZNF587 [nucleoplasm] (R-HSA-2127565)	0.556	3
UniProt:Q9UJX0 OSGI1			0.556	3
UniProt:Q9Y2X8 UBE2D4	1	UBE2D4 [cytosol] (R-HSA-947623)	0.556	3
UniProt:Q9Y2P0 ZN835			0.556	3
UniProt:Q92917 GPKOW	1	GPKOW [nucleoplasm] (R-HSA-8850839)	0.556	3
UniProt:Q2TBE0 CWF19L2	1	CWF19L2 [nucleoplasm] (R-HSA-9770846)	0.556	3
UniProt:P28074 PSMB5	4	PSMB5 [cytosol] (R-HSA-68753) PSMB5 [nucleoplasm] (R-HSA-174344) pro-PSMB5 [cytosol] (R-HSA-9908135) PSMB5(1-59) [cytosol] (R-HSA-9908134)	0.556	3
UniProt:Q99633 PRPF18	1	PRPF18 [nucleoplasm] (R-HSA-5688093)	0.556	3
UniProt:O95391 SLU7	1	hSLU7 [nucleoplasm] (R-HSA-72073)	0.556	3
UniProt:P04083 ANXA1	2	ANXA1 [cytosol] (R-HSA-5263630) ANXA1 [extracellular region] (R-HSA-444539)	0.556	6
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P29083 GTF2E1	1	GTF2E1 [nucleoplasm] (R-HSA-65561)	0.547	2
UniProt:Q9NQC7 CYLD	3	CYLD [cytosol] (R-HSA-741420) p-S418-CYLD [cytosol] (R-HSA-5212667) K48polyUb-K338, K530-CYLD [cytosol] (R-HSA-9818664)	0.547	2
UniProt:Q13158 FADD	1	FADD [cytosol] (R-HSA-54639)	0.527	2
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.527	3
UniProt:Q13315 ATM	5	ATM [cytosol] (R-HSA-9665171) ATM [peroxisomal matrix] (R-HSA-9665169) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527) ATM [nucleoplasm] (R-HSA-69484) Ac-K3016-ATM [nucleoplasm] (R-HSA-5682043)	0.524	4
UniProt:Q13501 SQSTM1	7	SQSTM1 [cytosol] (R-HSA-193937) SQSTM1 [nucleoplasm] (R-HSA-210961) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967)	0.524	2
UniProt:Q5D1E8 ZC3H12A	1	ZC3H12A [nucleoplasm] (R-HSA-9774235)	0.524	2
UniProt:P05787 KRT8	1	KRT8 [cytosol] (R-HSA-446043)	0.508	2
UniProt:Q9UNS2 COPS3	2	COPS3 [nucleoplasm] (R-HSA-5697017) COPS3 [cytosol] (R-HSA-416973)	0.508	2
UniProt:Q4VCS5 AMOT			0.499	3
UniProt:Q9BVN2-2 RUSC1			0.499	4
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.499	3
UniProt:Q13535 ATR	1	ATR [nucleoplasm] (R-HSA-912443)	0.499	2
UniProt:Q9NYJ8 TAB2	4	TAB2 [cytosol] (R-HSA-168117) TAB2 [endosome membrane] (R-HSA-450279) TAB2 [plasma membrane] (R-HSA-168116) TAB2 [nucleoplasm] (R-HSA-1253323)	0.488	2
UniProt:P0DTD2 9b	3	p-S53-9b [cytosol] (R-COV-9758478) 9b [cytosol] (R-COV-9694649) 9b [mitochondrial outer membrane] (R-COV-9709803)	0.463	3
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.463	3

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