Reactome | Ubiquitination of NEMO by TRAF6

Ubiquitination of NEMO by TRAF6

Stable Identifier

R-HSA-202534

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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During the phosphorylation of the IKK beta, the regulatory subunit NEMO undergoes K-63-linked polyubiquitination. Ubiquitinated TRAF6 trimer, acts as a E3 ligase and induces this ubiquitination. The ubiquitin target sites in NEMO are not yet clearly identified. Studies of different NF-kB signaling pathways revealed several potential ubiquitination sites on NEMO (e.g., K285, K277, K309 and K399) (Fuminori et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
17728323	Identification of TRAF6-dependent NEMO polyubiquitination sites through analysis of a new NEMO mutation causing incontinentia pigmenti Sebban-Benin, H, Pescatore, A, Fusco, F, Pascuale, V, Gautheron, J, Yamaoka, S, Moncla, A, Ursini, MV, Courtois, G	Hum Mol Genet	2007
17047224	Regulation and function of IKK and IKK-related kinases Hacker, H, Karin, M	Sci STKE	2006