Calcineurin activates NFAT

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R-HSA-2025928
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Pathway
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Homo sapiens
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Signaling by the B cell receptor and the T cell receptor stimulate transcription by NFAT factors via calcium (reviewed in Gwack et al. 2007). Cytosolic calcium from intracellular stores and extracellular sources binds calmodulin and activates the protein phosphatase calcineurin. Activated calcineurin dephosphorylates NFATs in the cytosol, exposing nuclear localization sequences on the NFATs and causing the NFATs to be imported into the nucleus where they regulate transcription of target genes in complexes with other transcription factors such as AP-1 and JUN. Calcineurin in the target of the immunosuppressive drugs cyclosporin A and FK-506 (reviewed in Lee and Park 2006).

Literature References
PubMed ID Title Journal Year
16951543 Regulation of NFAT activation: a potential therapeutic target for immunosuppression

Lee, M, Park, J

Mol Cells 2006
17572487 Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes

Gwack, Y, Feske, S, Srikanth, S, Hogan, PG, Rao, A

Cell Calcium 2007
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