Reactome | FKBP1A [cytosol]

FKBP1A [cytosol]

Stable Identifier

R-HSA-2026007

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Peptidyl-prolyl cis-trans isomerase FKBP1A, FKB1A_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P05067

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Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Signaling by the B Cell Receptor (BCR) (Homo sapiens)
    - Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
      - Calcineurin activates NFAT (Homo sapiens)
        
        FKBP1A binds tacrolimus (Homo sapiens)
        
        FKBP1A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62942 FKBP1A

Gene Names

FKBP1A, FKBP1, FKBP12

Chain

initiator methionine:, chain:2-108

Reference Genes

BioGPS Gene:2280 FKBP1A

COSMIC (genes):FKBP1A FKBP1A

CTD Gene:2280 FKBP1A

dbSNP Gene:2280 FKBP1A

ENSEMBL:ENSG00000088832 FKBP1A

ENSEMBL_homo_sapiens_GENE:ENSG00000088832.18 FKBP1A

HGNC:3711 FKBP1A

KEGG Gene (Homo sapiens):2280 FKBP1A

Monarch:2280 FKBP1A

NCBI Gene:2280 FKBP1A

OMIM:186945 FKBP1A

UCSC:P62942 FKBP1A

Reference Transcript

Other Identifiers

11715389_x_at

11715390_s_at

11729707_at

11753825_x_at

200709_PM_at

200709_at

210186_PM_s_at

210186_s_at

210187_PM_at

210187_at

214119_PM_s_at

214119_s_at

2280

2911840

2911842

3894602

3894603

3894604

3894605

3894606

3894607

3894608

3894609

3894610

3894611

3894612

3894615

3894623

3894625

3894626

3894627

8064432

8120428

880_at

952_at

953_g_at

A_23_P154667

A_23_P397238

A_24_P160001

A_32_P50522

A_33_P3227345

GE57943

GO:0000413

GO:0002376

GO:0003007

GO:0003755

GO:0003824

GO:0005160

GO:0005515

GO:0005527

GO:0005528

GO:0005737

GO:0005783

GO:0005829

GO:0005886

GO:0006457

GO:0006458

GO:0014802

GO:0016020

GO:0016529

GO:0016853

GO:0022417

GO:0023052

GO:0030018

GO:0030512

GO:0030547

GO:0032092

GO:0032515

GO:0032880

GO:0032926

GO:0033017

GO:0034713

GO:0036211

GO:0042026

GO:0042110

GO:0043123

GO:0043226

GO:0044325

GO:0048856

GO:0050776

GO:0051604

GO:0055010

GO:0055065

GO:0055085

GO:0060314

GO:0060347

GO:0070411

GO:0070588

GO:0070697

GO:0097435

GO:0098562

GO:0098772

GO:0140096

GO:1902991

GO:1990000

GO:1990425

HMNXSV003028168

HMNXSV003058209

Hs.752.2.A1_3p_a_at

ILMN_1683658

ILMN_1702237

ILMN_2333367

M34539_at

PH_hs_0035862

TC20001741.hg

g13477342_3p_at

g4503724_3p_s_at

Participates

as a component of

as a member of

PPIase [cytosol] (Homo sapiens)

as an input of

as an output of

Inferred To

FPR1 [cytosol] (Saccharomyces cerevisiae)

Homologues of FKBP1A [cytosol] (Caenorhabditis elegans)

Homologues of FKBP1A [cytosol] (Canis familiaris)

fkb-2 [cytosol] (Caenorhabditis elegans)

Fkbp12 [cytosol] (Drosophila melanogaster)

fkb-8 [cytosol] (Caenorhabditis elegans)

FKBP1A [cytosol] (Bos taurus)

FKBP1A [cytosol] (Canis familiaris)

FKBP1A [cytosol] (Dictyostelium discoideum)

FKBP1A [cytosol] (Sus scrofa)

LOC119881669 [cytosol] (Canis familiaris)

fkh1 [cytosol] (Schizosaccharomyces pombe)

Fkbp1a [cytosol] (Mus musculus)

Fkbp1a [cytosol] (Rattus norvegicus)

fkbp1b [cytosol] (Xenopus tropicalis)

si:dkeyp-115a10.1 [cytosol] (Danio rerio)

FKBP12 [cytosol] (Gallus gallus)

Cross References

RefSeq

NP_000792.1, NP_463460.1

ZINC - World Drugs

FKB1A_HUMAN

Guide to Pharmacology - Targets

2609

OpenTargets

ENSG00000088832

ZINC - FDA approved

FKB1A_HUMAN

ZINC - Substances

FKB1A_HUMAN

ZINC - Biogenic

FKB1A_HUMAN

ZINC target

P62942

PRO

P62942

PDB

4ODQ, 2PPP, 1FKI, 4FAP, 6M4U, 2ND5, 3H9R, 1BKF, 1FKH, 8CHJ, 4N19, 6VCU, 8CHI, 1A7X, 1NSG, 1FKD, 7U8D, 1J4R, 8ER7, 1QPF, 6YF2, 1J4H, 3FAP, 1D6O, 2PPN, 1FKS, 8JD0, 4IPX, 1EYM, 8PPZ, 8JD1, 5I7P, 7EPD, 1BL4, 8CHL, 8ER6, 2DG3, 1FKT, 8ERA, 8JCY, 4DH0, 2FAP, 8JD4, 8JCW, 6YF3, 1F40, 1FKB, 1QPL, 8JD2, 6YF1, 1FKJ, 6OQA, 1D7H, 8JCV, 8CHM, 7U0T, 2DG9, 4ODP, 1FKR, 2RSE, 1FAP, 1FKF, 2FKE, 1D7I, 5I7Q, 8JCU, 6YF0, 2DG4, 1FKG, 1J4I, 6I1S, 1B6C, 2PPO, 4ODR, 3MDY, 1D7J, 8JCZ, 8CHK, 8JCX

IntEnz

5.2.1.8

GeneCards

P62942

HPA

ENSG00000088832-FKBP1A

Ensembl

ENST00000678408, ENSP00000371138, ENST00000400137, ENST00000381719, ENST00000381724, ENSG00000088832, ENSP00000383003, ENST00000677335, ENSP00000371143, ENSP00000503152, ENSP00000503033

Pharos - Targets

P62942

Orphanet

24541

ZINC - Predictions - Purchasable

FKB1A_HUMAN

HMDB Protein

HMDBP07685

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42345 MTOR	2	MTOR [nucleoplasm] (R-HSA-5083674) MTOR [cytosol] (R-HSA-165662)	0.786	5
UniProt:P11716 RYR1			0.702	3
UniProt:P36897 TGFBR1	13	Ub-TGFBR1 [plasma membrane] (R-HSA-8869461) p-4S,T185,T186-TGFBR1 W242* [plasma membrane] (R-HSA-3656504) p-4S,T185,T186-TGFBR1 P327Qfs8 [plasma membrane] (R-HSA-3656505) p-4S,T185,T186-TGFBR1 L354Nfs4 [plasma membrane] (R-HSA-3656506) p-4S,T185,T186-TGFBR1 R414* [plasma membrane] (R-HSA-3656508) p-4S,T185,T186-TGFBR1 D269_Q324del [plasma membrane] (R-HSA-3656509) TGFBR1 G52R [plasma membrane] (R-HSA-3656368) TGFBR1 C41Y [plasma membrane] (R-HSA-3656328) TGFBR1 N45S [plasma membrane] (R-HSA-3656348) TGFBR1 P83L [plasma membrane] (R-HSA-3656341) TGFBR1 P83S [plasma membrane] (R-HSA-3656326) TGFBR1 [plasma membrane] (R-HSA-170839) p-4S,T185,T186-TGFBR1 [plasma membrane] (R-HSA-170849)	0.592	2
UniProt:O15105 SMAD7	2	SMAD7 [nucleoplasm] (R-HSA-178197) SMAD7 [cytosol] (R-HSA-173478)	0.581	3
UniProt:Q9NZD4 AHSP			0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P0C6X7-PRO_0000037312 REP			0.508	2
UniProt:P0C6X7-PRO_0000037309 REP			0.508	4
UniProt:P36896 ACVR1B	2	ACVR1B [plasma membrane] (R-HSA-205867) p-4S,T188,T206-ACVR1B [plasma membrane] (R-HSA-205780)	0.508	2

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