Formation of a heteromeric BMP receptor complex

Stable Identifier
R-HSA-202604
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

BMP receptors, unlike TGF-beta receptors are known to form hetero-oligomeric complexes in the endoplasmic reticulum and are transported as oligomers to the plasma membrane where they bind ligand. However, evidence for ligand-induced heteromeric BMP receptor complexes on the cell surface has also been published, leading to a model where both pre-formed and ligand-induced receptor oligomers are encountered on the plasma membrane. Based on the latter, a theory has been formulated that suggests that the signaling outcome from pre-formed and ligand-induced BMP receptor complexes is different. The mechanism that might explain this theory must involve different ways of internalization and trafficking of the BMP receptor complexes.

Literature References
PubMed ID Title Journal Year
16672363 Structure of the ternary signaling complex of a TGF-beta superfamily member

Allendorph, GP, Vale, WW, Choe, S

Proc Natl Acad Sci U S A 2006
10712517 Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors

Gilboa, L, Nohe, A, Geissendorfer, T, Sebald, W, Henis, YI, Knaus, P

Mol Biol Cell 2000
11714695 The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways

Nohe, A, Hassel, S, Ehrlich, M, Neubauer, F, Sebald, W, Henis, YI, Knaus, P

J Biol Chem 2002
Participants
Participant Of
hasEvent
Orthologous Events
Authored
Reviewed