I-Smad competes with Co-Smad for R-Smad1/5/8

Stable Identifier
R-HSA-202626
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytoplasmic side of plasma membrane
ReviewStatus
5/5
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I-Smad competes with Co-Smad for R-Smad1/5/8
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
I-SMAD selectively antagonizes BMP-activated Smad1/5/9 by acting as a CO-SMAD decoy.
Literature References
PubMed ID Title Journal Year
9436979 Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

Massague, J, Lagna, G, Hemmati-Brivanlou, A, Hata, A

Genes Dev 1998
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
negative regulation of BMP signaling pathway (0030514)
Orthologous Events
I-Smad competes with Co-Smad for R-Smad1/5/8 (Bos taurus)
I-Smad competes with Co-Smad for R-Smad1/5/8 (Caenorhabditis elegans)
I-Smad competes with Co-Smad for R-Smad1/5/8 (Canis familiaris)
I-Smad competes with Co-Smad for R-Smad1/5/8 (Danio rerio)
I-Smad competes with Co-Smad for R-Smad1/5/8 (Drosophila melanogaster)
I-Smad competes with Co-Smad for R-Smad1/5/8 (Gallus gallus)
I-Smad competes with Co-Smad for R-Smad1/5/8 (Mus musculus)
I-Smad competes with Co-Smad for R-Smad1/5/8 (Rattus norvegicus)
I-Smad competes with Co-Smad for R-Smad1/5/8 (Sus scrofa)
Authored
Huminiecki, L  (2007-11-07)
Moustakas, A  (2007-11-07)
Reviewed
Heldin, CH  (2007-11-12)
Created
Jassal, B  (2007-11-07)
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