Integrin alpha4beta1 binds JAM2:JAM3

Stable Identifier
R-HSA-202706
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Several key IgSF cell adhesion molecules engage integrin and in so doing impact on the multi-step paradigm of leukocyte emigration. The interaction between JAM2 (JAM-B) and Integrin alpha4beta1 (VLA-4) requires prior inding of JAM2 to JAM3 (JAM-C).

Literature References
PubMed ID Title Journal Year
17525755 The role of junctional adhesion molecules in vascular inflammation

Weber, C, Fraemohs, L, Dejana, E

Nat Rev Immunol 2007
12070135 JAM2 interacts with alpha4beta1. Facilitation by JAM3.

Cunningham, SA, Rodriguez, JM, Arrate, MP, Tran, TM, Brock, TA

J Biol Chem 2002
Participants
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Orthologous Events
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Created