Integrin alpha4beta1 binds JAM2:JAM3

Stable Identifier
R-HSA-202706
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Several key IgSF cell adhesion molecules engage integrin and in so doing impact on the multi-step paradigm of leukocyte emigration. The interaction between JAM2 (JAM-B) and Integrin alpha4beta1 (VLA-4) requires prior inding of JAM2 to JAM3 (JAM-C).

Literature References
PubMed ID Title Journal Year
17525755 The role of junctional adhesion molecules in vascular inflammation Nat Rev Immunol 2007
12070135 JAM2 interacts with alpha4beta1. Facilitation by JAM3. J Biol Chem 2002
Participants
Participant Of
Orthologous Events