CD84 homodimerises

Stable Identifier
R-HSA-202713
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CD84 is a homophilic receptor expressed on T cells, B cells, dendritic cells, monocytes, macrophages, eosinophils, mast cells, granulocytes, and platelets. CD84 expression increases following activation of T cells, B cells, and dendritic cells. CD84 homophilic engagement is known to induce platelet stimulation.

Literature References
PubMed ID Title Journal Year
17563375 Structure of CD84 provides insight into SLAM family function

Yan, Q, Malashkevich, VN, Fedorov, A, Fedorov, E, Cao, E, Lary, JW, Cole, JL, Nathenson, SG, Almo, SC

Proc Natl Acad Sci U S A 2007
11564780 CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1

Martin, M, Romero, X, de la Fuente, MA, Tovar, V, Zapater, N, Esplugues, E, Pizcueta, P, Bosch, J, Engel, P

J Immunol 2001
Participants
Participant Of
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Created