Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A)

Stable Identifier
R-HSA-202718
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

JAM-A plays a key role in leukocyte transmigration and inflammatory extravasation. Transmigration of human leukocytes has been shown to involve heterophilic interactions of JAM-A with its integrin receptor LFA-1.

Literature References
PubMed ID Title Journal Year
15528364 The functional interaction of the beta 2 integrin lymphocyte function-associated antigen-1 with junctional adhesion molecule-A is mediated by the I domain

Fraemohs, L, Koenen, RR, Ostermann, G, Heinemann, B, Weber, C

J Immunol 2004
15681301 Involvement of JAM-A in mononuclear cell recruitment on inflamed or atherosclerotic endothelium: inhibition by soluble JAM-A

Ostermann, G, Fraemohs, L, Baltus, T, Schober, A, Lietz, M, Zernecke, A, Liehn, EA, Weber, C

Arterioscler Thromb Vasc Biol 2005
11812992 JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes

Ostermann, G, Weber, KS, Zernecke, A, Schroder, A, Weber, C

Nat Immunol 2002
17525755 The role of junctional adhesion molecules in vascular inflammation

Weber, C, Fraemohs, L, Dejana, E

Nat Rev Immunol 2007
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created