JAM2 binds JAM3

Stable Identifier
R-HSA-202721
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

JAM2 and JAM3 bind each other and are strongly expressed by endothelial cells of high endothelial venules, the predominant site of leukocyte extravasation. JAM2 and JAM3 also bind to the leukocyte integrins VLA-4 and Mac-1 respectively.

Literature References
PubMed ID Title Journal Year
17525755 The role of junctional adhesion molecules in vascular inflammation

Weber, C, Fraemohs, L, Dejana, E

Nat Rev Immunol 2007
16297198 Junctional adhesion molecules (JAM)-B and -C contribute to leukocyte extravasation to the skin and mediate cutaneous inflammation

Ludwig, RJ, Zollner, TM, Santoso, S, Hardt, K, Gille, J, Baatz, H, Johann, PS, Pfeffer, J, Radeke, HH, Schon, MP, Kaufmann, R, Boehncke, WH, Podda, M

J Invest Dermatol 2005
Participants
Participant Of
Orthologous Events
Authored
Reviewed