Cell surface interactions at the vascular wall

Stable Identifier
R-HSA-202733
Type
Pathway
Species
Homo sapiens
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Summation

Leukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are required for leukocytes to withstand local flow at the vessel wall is a multistep process mediated by different adhesion molecules. Platelets adhered to injured vessel walls form strong adhesive substrates for leukocytes. For instance, the initial tethering and rolling of leukocytes over the site of injury are mediated by reversible binding of selectins to their cognate cell-surface glycoconjugates.

Endothelial cells are tightly connected through various proteins, which regulate the organization of the junctional complex and bind to cytoskeletal proteins or cytoplasmic interaction partners that allow the transfer of intracellular signals. An important role for these junctional proteins in governing the transendothelial migration of leukocytes under normal or inflammatory conditions has been established.

This pathway describes some of the key interactions that assist in the process of platelet and leukocyte interaction with the endothelium, in response to injury.

Literature References
PubMed ID Title Journal Year
17525755 The role of junctional adhesion molecules in vascular inflammation

Weber, C, Fraemohs, L, Dejana, E

Nat Rev Immunol 2007
14615387 Platelet-monocyte complexes support monocyte adhesion to endothelium by enhancing secondary tethering and cluster formation

da Costa Martins, P, van den Berk, N, Ulfman, LH, Koenderman, L, Hordijk, PL, Zwaginga, JJ

Arterioscler Thromb Vasc Biol 2004
16115029 Mechanisms of monocyte recruitment in vascular repair after injury

Schober, A, Weber, C

Antioxid Redox Signal 2005
10798271 Endothelial function and hemostasis

Becker, BF, Heindl, B, Kupatt, C, Zahler, S

Z Kardiol 2000
11282294 Platelets and the injured vessel wall-- "rolling into action": focus on glycoprotein Ib/V/IX and the platelet cytoskeleton

Jackson, SP, Mistry, N, Yuan, Y

Trends Cardiovasc Med 2000
8578462 The molecular basis of platelet and endothelial cell interaction with neutrophils and monocytes: role of P-selectin and the P-selectin ligand, PSGL-1

Furie, B, Furie, BC

Thromb Haemost 1995
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