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ITGAM [plasma membrane]
Stable Identifier
R-HSA-202757
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Integrin alpha-M precursor, ITAM_HUMAN, CD11b
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
Integrin alphaMbeta2 (MAC1) binds JAM3 (Homo sapiens)
Integrin alphaMbeta2 [plasma membrane] (Homo sapiens)
ITGAM [plasma membrane] (Homo sapiens)
Integrin alphaMbeta2:JAM3 [plasma membrane] (Homo sapiens)
Integrin alphaMbeta2 [plasma membrane] (Homo sapiens)
ITGAM [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
Integrin alphaMbeta2 (MAC1) binds JAM3 (Homo sapiens)
Integrin alphaMbeta2 [plasma membrane] (Homo sapiens)
ITGAM [plasma membrane] (Homo sapiens)
Integrin alphaMbeta2:JAM3 [plasma membrane] (Homo sapiens)
Integrin alphaMbeta2 [plasma membrane] (Homo sapiens)
ITGAM [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of IL13-upregulated plasma membrane proteins (Homo sapiens)
IL13-upregulated proteins [plasma membrane] (Homo sapiens)
ITGAM [plasma membrane] (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of specific granule membrane proteins (Homo sapiens)
Specific granule membrane proteins [plasma membrane] (Homo sapiens)
ITGAM [plasma membrane] (Homo sapiens)
Exocytosis of tertiary granule membrane proteins (Homo sapiens)
Tertiary granule membrane proteins [plasma membrane] (Homo sapiens)
ITGAM [plasma membrane] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
CD14:LPS binds CR3 (Homo sapiens)
Integrin alphaMbeta2 [plasma membrane] (Homo sapiens)
ITGAM [plasma membrane] (Homo sapiens)
LPS:CD14:CR3 [plasma membrane] (Homo sapiens)
Integrin alphaMbeta2 [plasma membrane] (Homo sapiens)
ITGAM [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P11215 ITGAM
Gene Names
ITGAM, CD11B, CR3A
Chain
signal peptide:1-16, chain:17-1152
Reference Genes
BioGPS Gene:3684 ITGAM
COSMIC (genes):ITGAM ITGAM
CTD Gene:3684 ITGAM
dbSNP Gene:3684 ITGAM
ENSEMBL:ENSG00000169896 ITGAM
ENSEMBL_homo_sapiens_GENE:ENSG00000169896.18 ITGAM
HGNC:6149 ITGAM
KEGG Gene (Homo sapiens):3684 ITGAM
Monarch:3684 ITGAM
NCBI Gene:3684 ITGAM
OMIM:120980 ITGAM
UCSC:P11215 ITGAM
Reference Transcript
RefSeq:NM_000632.3 ITGAM
RefSeq:NM_001145808.1 ITGAM
Other Identifiers
11732479_a_at
11732480_s_at
11732481_a_at
16818239
205786_PM_s_at
205786_s_at
3656991
3656992
3656993
3656994
3656995
3656997
3656998
3656999
3657000
3657001
3657002
3657004
3657005
3657006
3657007
3657009
3657010
3657011
3657012
3657013
3657014
3657015
3657017
3657018
3657020
3657023
3657025
3657026
3657028
3657029
3657030
3657031
3657033
3657034
3657035
3657036
3657071
3684
38533_s_at
7995096
A_14_P101991
A_14_P119686
A_23_P124108
GE57493
GO:0001540
GO:0001774
GO:0001851
GO:0002376
GO:0002430
GO:0002931
GO:0005178
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0006886
GO:0006898
GO:0006911
GO:0006954
GO:0007155
GO:0007160
GO:0007229
GO:0008305
GO:0009612
GO:0009897
GO:0009986
GO:0010668
GO:0016020
GO:0016192
GO:0023052
GO:0030154
GO:0030900
GO:0031072
GO:0031410
GO:0032355
GO:0032930
GO:0033627
GO:0034113
GO:0034330
GO:0034688
GO:0035579
GO:0038024
GO:0043226
GO:0043315
GO:0044853
GO:0044877
GO:0045087
GO:0045121
GO:0045963
GO:0046872
GO:0048856
GO:0061024
GO:0070062
GO:0070821
GO:0090314
GO:0097242
GO:0098542
GO:0098609
GO:0098742
GO:0140459
GO:0150062
GO:0150064
GO:1904151
GO:1904643
GO:2000363
HMNXSV003026447
HMNXSV003055515
ILMN_1685009
J03925_at
PH_hs_0010328
TC16000374.hg
g6006013_3p_at
Participates
as a member of
IL13-upregulated proteins [plasma membrane] (Homo sapiens)
Specific granule membrane proteins [plasma membrane] (Homo sapiens)
Tertiary granule membrane proteins [plasma membrane] (Homo sapiens)
as a component of
Integrin alphaMbeta2 [plasma membrane] (Homo sapiens)
Other forms of this molecule
ITGAM [specific granule membrane]
ITGAM [tertiary granule membrane]
Inferred To
if [plasma membrane]
(Drosophila melanogaster)
itgam.1 [plasma membrane]
(Danio rerio)
ITGAM [plasma membrane]
(Bos taurus)
ITGAM [plasma membrane]
(Canis familiaris)
ITGAM [plasma membrane]
(Gallus gallus)
ITGAM [plasma membrane]
(Mus musculus)
ITGAM [plasma membrane]
(Sus scrofa)
pat-2 [plasma membrane]
(Caenorhabditis elegans)
itgad [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_000623.2
,
NP_001139280.1
Guide to Pharmacology - Targets
2452
OpenTargets
ENSG00000169896
HPA
ENSG00000169896-ITGAM
GeneCards
P11215
Ensembl
ENSG00000169896
,
ENST00000648685
,
ENSP00000496959
,
ENST00000544665
,
ENSP00000441691
PRO
P11215
Pharos - Targets
P11215
Orphanet
22233
PDB
7USL
,
1IDN
,
1JLM
,
3QA3
,
3Q3G
,
2LKJ
,
1NA5
,
8CE9
,
1IDO
,
7P2D
,
1BHO
,
4M76
,
1M1U
,
7USM
,
1BHQ
,
6RHW
,
7AKK
,
1MF7
,
4XW2
,
1N9Z
,
8CE6
,
2LKE
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P21246 PTN
1
PTN [extracellular region]
(R-HSA-201500)
0.618
3
UniProt:Q96BA8 CREB3L1
7
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.556
3
UniProt:Q7Z5P4 HSD17B13
1
HSD17B13 [cytosol]
(R-HSA-8862029)
0.556
3
UniProt:Q6IN84 MRM1
1
MRM1 [mitochondrial matrix]
(R-HSA-6793088)
0.556
3
UniProt:Q8N4V1 MMGT1
1
MMGT1 [Golgi membrane]
(R-HSA-5216137)
0.556
3
UniProt:Q3KNW5 SLC10A6
1
SLC10A6 [plasma membrane]
(R-HSA-433091)
0.556
3
UniProt:P08034 GJB1
2
GJB1 [endoplasmic reticulum-Golgi intermediate compartment]
(R-HSA-190636)
GJB1 [endoplasmic reticulum membrane]
(R-HSA-190656)
0.556
3
UniProt:Q3SXY8 ARL13B
8
PolyUb-Misfolded ARL13B [lysosomal lumen]
(R-HSA-9660004)
PolyUb-Misfolded ARL13B [cytosol]
(R-HSA-9641129)
Ub-Misfolded ARL13B [cytosol]
(R-HSA-9641119)
Misfolded ARL13B [cytosol]
(R-HSA-9640110)
Misfolded ARL13B [cilium]
(R-HSA-9640116)
ARL13B [cilium]
(R-HSA-5618181)
PolyUb-Misfolded ARL13B [late endosome lumen]
(R-HSA-9659986)
ARL13B [plasma membrane]
(R-HSA-9716787)
0.556
3
UniProt:O15173 PGRMC2
4
PGRMC2 [nuclear envelope]
(R-HSA-9707674)
PGRMC2 [nucleoplasm]
(R-HSA-9707859)
PGRMC2 [endoplasmic reticulum membrane]
(R-HSA-9714349)
PGRMC2 [endosome membrane]
(R-HSA-9715090)
0.556
3
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