Reactome | LATS1 [cytosol]

LATS1 [cytosol]

Stable Identifier

R-HSA-2028562

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Serine/threonine-protein kinase LATS1, WARTS protein kinase

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External Reference Information

External Reference

UniProt:O95835 LATS1

Gene Names

LATS1, WARTS

Chain

chain:1-1130

Reference Genes

BioGPS Gene:9113 LATS1

COSMIC (genes):LATS1 LATS1

CTD Gene:9113 LATS1

dbSNP Gene:9113 LATS1

ENSEMBL:ENSG00000131023 LATS1

HGNC:6514 LATS1

KEGG:hsa:9113 LATS1

Monarch:9113 LATS1

NCBI Gene:9113 LATS1

OMIM:603473 LATS1

UCSC:O95835 LATS1

Reference Transcript

Other Identifiers

11740127_a_at

11745334_a_at

11751496_a_at

1570231_PM_at

1570231_at

1570425_PM_s_at

1570425_s_at

17024615

219813_PM_at

219813_at

227772_PM_at

227772_at

2978990

2978991

2978992

2978993

2978994

2978995

2978997

2978998

2978999

2979000

2979019

2979020

2979021

2979023

2979024

2979026

2979027

2979028

2979029

2979030

2979031

2979032

2979033

2979034

2979035

2979038

2979039

2979040

2979041

2979046

2979047

2979048

46129_at

8130116

9113

A_23_P366230

A_33_P3233764

GE58342

GO:0000082

GO:0000086

GO:0000287

GO:0000819

GO:0000922

GO:0001827

GO:0001828

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005813

GO:0005815

GO:0005816

GO:0005819

GO:0005829

GO:0005856

GO:0006468

GO:0007059

GO:0008104

GO:0009755

GO:0016740

GO:0017015

GO:0019901

GO:0030154

GO:0030216

GO:0030331

GO:0030496

GO:0030833

GO:0033138

GO:0033146

GO:0035329

GO:0043065

GO:0043226

GO:0043254

GO:0045736

GO:0046620

GO:0046872

GO:0051220

GO:0051301

GO:0060644

GO:0090090

GO:0098794

GO:0098978

GO:0099151

GO:0106310

GO:0140096

GO:1900181

GO:2000058

HMNXSV003051946

Hs.250691.0.A1_3p_at

Hs2.250691.1.A1_3p_at

Hs2.250691.2.A1_3p_s_at

ILMN_1696921

ILMN_2108029

PH_hs_0040488

TC06002214.hg

g10862687_3p_at

g10862687_3p_x_at

Participates

as a member of

LATS [cytosol] (Homo sapiens)

Other forms of this molecule

p-S909,T1079-LATS1 [cytosol]

Inferred To

LATS1 [cytosol] (Bos taurus)

LATS1 [cytosol] (Caenorhabditis elegans)

LATS1 [cytosol] (Canis familiaris)

LATS1 [cytosol] (Danio rerio)

LATS1 [cytosol] (Drosophila melanogaster)

LATS1 [cytosol] (Gallus gallus)

LATS1 [cytosol] (Mus musculus)

LATS1 [cytosol] (Sus scrofa)

LATS1 [cytosol] (Xenopus tropicalis)

Lats1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001257448.1, NP_004681.1

ZINC - World Drugs

LATS1_HUMAN

Guide to Pharmacology - Targets

1515

OpenTargets

ENSG00000131023

ENSEMBL

ENSP00000437550, ENSP00000253339, ENSP00000444678, ENST00000253339, ENST00000543571, ENST00000392273

ZINC - FDA approved

LATS1_HUMAN

ZINC - Substances

LATS1_HUMAN

ZINC target

O95835

ZINC - Biogenic

LATS1_HUMAN

PRO

O95835

GlyGen

O95835

PDB

5B5W, 4ZRK, 7LWH, 5BRK

ZINC - Investigational

LATS1_HUMAN

HPA

ENSG00000131023-LATS1

Pharos - Targets

O95835

ZINC - Predictions - Purchasable

LATS1_HUMAN

HMDB Protein

HMDBP01499

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46937 YAP1	8	YAP1 [nucleoplasm] (R-HSA-1253322) YAP1 [cytosol] (R-HSA-1253345) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y407-YAP1 [cytosol] (R-HSA-9865208)	0.88	10
UniProt:Q9GZV5 WWTR1	3	WWTR1 [nucleoplasm] (R-HSA-1629775) WWTR1 [cytosol] (R-HSA-1629773) p-S89-WWTR1 [cytosol] (R-HSA-2028665)	0.641	5
UniProt:P06493 CDK1	11	p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) CDK1 [cytosol] (R-HSA-170075) CDK1 [nucleoplasm] (R-HSA-68889) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-Y4-CDK1 [cytosol] (R-HSA-9836187) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424)	0.632	3
UniProt:P24941 CDK2	5	p-T160-CDK2 [nucleoplasm] (R-HSA-187967) CDK2 [nucleoplasm] (R-HSA-68365) CDK2 [cytosol] (R-HSA-157440) p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905)	0.576	4
UniProt:P53667 LIMK1	3	LIMK1 [cytosol] (R-HSA-397785) p-T508-LIMK1 [cytosol] (R-HSA-399816) p-S,T508-LIMK1 [cytosol] (R-HSA-419610)	0.556	5
UniProt:P35240 NF2	1	NF2 [plasma membrane] (R-HSA-5669168)	0.556	4
UniProt:P46662	1	Nf2 [plasma membrane] (R-MMU-5669168)	0.537	5
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.499	2
UniProt:Q15831 STK11	2	STK11 [cytosol] (R-HSA-380954) STK11 [nucleoplasm] (R-HSA-164119)	0.499	2
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.483	3

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