Reactome | p-S872,T1041-LATS2 [cytosol]

p-S872,T1041-LATS2 [cytosol]

Stable Identifier

R-HSA-2028565

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-LATS2, phospho-Serine/threonine-protein kinase LATS2, phospho-WARTS-like protein kinase

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9NRM7 LATS2

Gene Names

LATS2, KPM

Chain

chain:1-1088

Reference Genes

BioGPS Gene:26524 LATS2

COSMIC (genes):LATS2 LATS2

CTD Gene:26524 LATS2

dbSNP Gene:26524 LATS2

ENSEMBL:ENSG00000150457 LATS2

ENSEMBL_homo_sapiens_GENE:ENSG00000150457.9 LATS2

HGNC:6515 LATS2

KEGG Gene (Homo sapiens):26524 LATS2

Monarch:26524 LATS2

NCBI Gene:26524 LATS2

OMIM:604861 LATS2

UCSC:Q9NRM7 LATS2

Reference Transcript

Other Identifiers

11721738_a_at

11721739_a_at

11755581_a_at

16777259

223379_PM_s_at

223379_s_at

223380_PM_s_at

223380_s_at

227013_PM_at

227013_at

26524

3504527

3504528

3504529

3504530

3504532

3504535

3504537

3504539

3504540

3504541

3504542

3504543

3504544

3504545

3504546

3504547

3504549

3504574

3504575

3504576

3504577

60514_at

7970498

83093_at

A_23_P204958

A_24_P70002

GE53689

GO:0000082

GO:0000166

GO:0000278

GO:0000922

GO:0001827

GO:0001828

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006468

GO:0007049

GO:0008104

GO:0009755

GO:0012501

GO:0016301

GO:0016310

GO:0016740

GO:0017015

GO:0023052

GO:0030154

GO:0030216

GO:0034451

GO:0035329

GO:0035556

GO:0036211

GO:0043065

GO:0043226

GO:0045736

GO:0046620

GO:0046872

GO:0048856

GO:0051301

GO:0060070

GO:0090090

GO:0106310

GO:0140096

GO:1900181

HMNXSV003020793

Hs.19074.0.S1_3p_a_at

Hs.19074.1.S1_3p_at

ILMN_1703412

PH_hs_0035470

TC13000463.hg

g8886763_3p_a_at

Participates

as a component of

p-LATS2:p-MOB1 [cytosol] (Homo sapiens)

as a member of

p-LATS [cytosol] (Homo sapiens)

Other forms of this molecule

LATS2 [cytosol]

Inferred To

phospho-Lats2 [cytosol] (Rattus norvegicus)

phospho-LATS2 [cytosol] (Gallus gallus)

phospho-p-S872,T1041-LATS2 [cytosol] (Bos taurus)

phospho-p-S872,T1041-LATS2 [cytosol] (Caenorhabditis elegans)

phospho-p-S872,T1041-LATS2 [cytosol] (Canis familiaris)

phospho-p-S872,T1041-LATS2 [cytosol] (Danio rerio)

phospho-p-S872,T1041-LATS2 [cytosol] (Drosophila melanogaster)

phospho-p-S872,T1041-LATS2 [cytosol] (Mus musculus)

phospho-p-S872,T1041-LATS2 [cytosol] (Sus scrofa)

Modified Residues

Name

O-phospho-L-serine at 872

Coordinate

872

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 1041

Coordinate

1041

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_055387.2, XP_005266399.1

ZINC - World Drugs

LATS2_HUMAN

Guide to Pharmacology - Targets

1516

OpenTargets

ENSG00000150457

ZINC - FDA approved

LATS2_HUMAN

ZINC - Substances

LATS2_HUMAN

ZINC - Biogenic

LATS2_HUMAN

ZINC target

Q9NRM7

PRO

Q9NRM7

PDB

4ZRI

ZINC - Investigational

LATS2_HUMAN

GeneCards

Q9NRM7

HPA

ENSG00000150457-LATS2

Ensembl

ENSP00000372035, ENSG00000150457, ENST00000382592

Pharos - Targets

Q9NRM7

ZINC - Predictions - Purchasable

LATS2_HUMAN

HMDB Protein

HMDBP01406

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43255 SIAH2	1	SIAH2 [cytosol] (R-HSA-374566)	0.632	6
UniProt:Q96IF1 AJUBA	3	AJUBA [nucleoplasm] (R-HSA-5687935) p-S-AJUBA [cytosol] (R-HSA-2574841) AJUBA [cytosol] (R-HSA-2564698)	0.625	6
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.499	2
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.488	2