STK4(327-487) [cytosol]

Stable Identifier
R-HSA-2028668
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
STK4/C, Serine/threonine-protein kinase 4 18kDa subunit, MST1/C
Locations in the PathwayBrowser for interactor UniProt:Q9P0L0 VAPA
Expand all
Literature References
PubMed ID Title Journal Year
11278283 MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation

Tsubuki, S, Yajima, N, Lee, KK, Ohyama, T, Yonehara, S

J Biol Chem 2001
9545236 Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1

Ambrose, DM, Krebs, EG, Han, DK, Gotoh, Y, Clark, EA, Draves, KE, Chernoff, J, Wright, M, Graves, JD

EMBO J 1998
External Reference Information
External Reference
UniProt:Q13043 STK4
Gene Names
STK4, KRS2, MST1
Chain
chain:1-487, chain:1-326, chain:327-487
Reference Genes
BioGPS Gene:6789 STK4
COSMIC (genes):STK4 STK4
CTD Gene:6789 STK4
dbSNP Gene:6789 STK4
ENSEMBL:ENSG00000101109 STK4
ENSEMBL_homo_sapiens_GENE:ENSG00000101109.13 STK4
HGNC:11408 STK4
KEGG Gene (Homo sapiens):6789 STK4
Monarch:6789 STK4
NCBI Gene:6789 STK4
OMIM:604965 STK4
UCSC:Q13043 STK4
Reference Transcript
Other Identifiers
11723400_a_at
11723401_x_at
11723402_a_at
11750551_a_at
11756934_a_at
16914147
205411_PM_at
205411_at
211085_PM_s_at
211085_s_at
225364_PM_at
225364_at
236259_PM_at
236259_at
36294_at
3886705
3886706
3886707
3886710
3886718
3886720
3886722
3886724
3886725
3886727
3886728
3886732
3886738
3886743
3886744
3886745
3886746
3886747
3886749
3886751
53858_at
59278_at
6789
77474_at
8062908
A_14_P120879
A_23_P143199
A_24_P185615
A_24_P94054
A_33_P3222648
GE511474
GE705798
GE81616
GE86072
GO:0000166
GO:0000287
GO:0000902
GO:0001569
GO:0001841
GO:0001934
GO:0003157
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006468
GO:0006606
GO:0006886
GO:0006913
GO:0006915
GO:0007155
GO:0007165
GO:0007417
GO:0008283
GO:0008285
GO:0008625
GO:0012501
GO:0016301
GO:0016310
GO:0016604
GO:0016740
GO:0018105
GO:0022414
GO:0023052
GO:0030154
GO:0030216
GO:0032092
GO:0032991
GO:0033138
GO:0035265
GO:0035329
GO:0035556
GO:0036211
GO:0042802
GO:0042803
GO:0043065
GO:0043226
GO:0043408
GO:0043539
GO:0045600
GO:0046621
GO:0046777
GO:0046872
GO:0048856
GO:0048870
GO:0050673
GO:0050680
GO:0050821
GO:0051262
GO:0060070
GO:0060215
GO:0060706
GO:0060800
GO:0061629
GO:0065003
GO:0090090
GO:0097284
GO:0098772
GO:0106310
GO:0140096
GO:1902043
GO:1903945
GO:1904237
HMNXSV003045854
HMNXSV003047655
Hs.250824.0.S1_3p_at
Hs.268051.0.A1_3p_at
ILMN_1711383
PH_hs_0002864
TC20000339.hg
TC20001234.hg
U18297_s_at
g405738_3p_s_at
g5454095_3p_at
Participates
as an output of
Other forms of this molecule
STK4(1-487) [cytosol]
p-T183-STK4(1-326) [cytosol]
p-T183-STK4(1-487) [cytosol]
Inferred To
STK4 [cytosol] (Canis familiaris)
STK4 [cytosol] (Gallus gallus)
STK4(327-487) [cytosol] (Bos taurus)
STK4(327-487) [cytosol] (Caenorhabditis elegans)
STK4(327-487) [cytosol] (Drosophila melanogaster)
STK4(327-487) [cytosol] (Mus musculus)
STK4(327-487) [cytosol] (Rattus norvegicus)
STK4(327-487) [cytosol] (Sus scrofa)
STK4(327-487) [cytosol] (Xenopus tropicalis)
Homologues of STK4(327-487) [cytosol] (Caenorhabditis elegans)
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
PDB
ZINC - Investigational
HPA
GeneCards
Ensembl
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (34)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9H4B6 SAV1  2 0.942 23
 UniProt:P50749 RASF2      0.926 19
 UniProt:Q13188 STK3  4 0.914 20
 UniProt:Q9NS23 RASF1      0.886 11
 UniProt:Q8WWW0 RASF5      0.88 9
 UniProt:Q9H2L5 RASF4      0.829 7
 UniProt:Q86WH2 RASF3      0.823 7
 UniProt:Q14BN4 SLMAP      0.787 8
 UniProt:Q6ZTQ3 RASF6      0.779 6
 UniProt:Q9H8S9 MOB1A  2 0.747 9
 UniProt:Q9NS23-2 RASSF1      0.729 4
 UniProt:P46821 MAP1B  1 0.725 4
 UniProt:Q66K74 MAP1S      0.706 5
 UniProt:Q9GZQ8 MAP1LC3B  3 0.688 8
 UniProt:Q13043 STK4  4 0.678 4
 UniProt:Q06830 PRDX1  3 0.66 11
 UniProt:P61981 YWHAG  1 0.65 3
 UniProt:Q9P0L0 VAPA  4 0.643 5
 UniProt:Q7L9L4 MOB1B  2 0.629 4
 UniProt:P31749 AKT1  14 0.619 13
 UniProt:O43815 STRN  5 0.615 4
 UniProt:P35700 Prdx1  3 0.611 3
 UniProt:Q8WWW0-2 RASSF5      0.581 4
 UniProt:Q99MK9 RASF1      0.564 2
 UniProt:P60520 GABARAPL2  3 0.544 2
 UniProt:O95166 GABARAP  3 0.544 2
 UniProt:Q9H0R8 GABARAPL1  3 0.544 2
 UniProt:O95292 VAPB  2 0.527 4
 UniProt:P11021 HSPA5  6 0.527 3
 UniProt:P04083 ANXA1  2 0.527 2
 UniProt:Q91VJ4  1 0.525 2
 UniProt:Q8WWW0-3 RASSF5      0.508 2
 UniProt:Q9NVK5 FGFR1OP2  2 0.483 2
 UniProt:Q13033 STRN3      0.483 3
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