Reactome | STK3(323-491) [cytosol]

STK3(323-491) [cytosol]

Stable Identifier

R-HSA-2028684

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

STK3/C, Serine/threonine-protein kinase 3 20kDa subunit, MST2/C

Locations in the PathwayBrowser for interactor UniProt:Q8TAQ5 ZNF420

Expand all

Literature References

PubMed ID	Title	Journal	Year
11278283	MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation Tsubuki, S, Yajima, N, Lee, KK, Ohyama, T, Yonehara, S	J Biol Chem	2001

External Reference Information

External Reference

UniProt:Q13188 STK3

Gene Names

STK3, KRS1, MST2

Chain

chain:1-491, chain:1-322, chain:323-491

Reference Genes

BioGPS Gene:6788 STK3

COSMIC (genes):STK3 STK3

CTD Gene:6788 STK3

dbSNP Gene:6788 STK3

ENSEMBL:ENSG00000104375 STK3

ENSEMBL_homo_sapiens_GENE:ENSG00000104375.17 STK3

HGNC:11406 STK3

KEGG Gene (Homo sapiens):6788 STK3

Monarch:6788 STK3

NCBI Gene:6788 STK3

OMIM:605030 STK3

UCSC:Q13188 STK3

Reference Transcript

Other Identifiers

11721152_a_at

11721153_a_at

11721154_a_at

11758670_s_at

17079477

204068_PM_at

204068_at

211078_PM_s_at

211078_s_at

3146124

3146125

3146126

3146127

3146147

3146148

3146155

3146170

3146171

3146174

3146201

3146203

3146212

3146213

3146214

3146219

3146220

3146221

3146222

3146229

32142_at

6788

8151967

A_23_P215963

A_33_P3260669

GE62016

GO:0000166

GO:0000287

GO:0001841

GO:0003157

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006351

GO:0006355

GO:0006468

GO:0006606

GO:0006886

GO:0006913

GO:0006915

GO:0007165

GO:0007254

GO:0007417

GO:0008283

GO:0008285

GO:0008625

GO:0012501

GO:0016301

GO:0016310

GO:0016740

GO:0022414

GO:0023052

GO:0030154

GO:0032092

GO:0032991

GO:0035265

GO:0035329

GO:0035556

GO:0036211

GO:0042802

GO:0043065

GO:0043226

GO:0043408

GO:0043491

GO:0043539

GO:0045600

GO:0046330

GO:0046621

GO:0046872

GO:0048856

GO:0050673

GO:0050680

GO:0050821

GO:0051091

GO:0051262

GO:0051897

GO:0060070

GO:0060215

GO:0060706

GO:0060800

GO:0065003

GO:0071539

GO:0090090

GO:0097284

GO:0098772

GO:0106310

GO:0140096

GO:1902043

HMNXSV003012407

ILMN_1666453

PH_hs_0010029

TC08002442.hg

U26424_at

U60206_s_at

g405722_3p_s_at

g5454093_3p_at

Participates

as an output of

Cleavage of p-STK3 (p-MST2) by caspase 3 (Homo sapiens)

Other forms of this molecule

p-T180-STK3(1-322) [cytosol]

STK3(1-491) [cytosol]

p-T180-STK3(1-491) [cytosol]

Inferred To

Homologues of STK3(323-491) [cytosol] (Caenorhabditis elegans)

STK3(323-491) [cytosol] (Bos taurus)

STK3(323-491) [cytosol] (Caenorhabditis elegans)

STK3(323-491) [cytosol] (Danio rerio)

STK3(323-491) [cytosol] (Drosophila melanogaster)

STK3(323-491) [cytosol] (Mus musculus)

STK3(323-491) [cytosol] (Rattus norvegicus)

STK3(323-491) [cytosol] (Sus scrofa)

STK3(323-491) [cytosol] (Xenopus tropicalis)

STK3 [cytosol] (Canis familiaris)

STK3 [cytosol] (Gallus gallus)

Cross References

RefSeq

NP_006272.2, NP_001243241.1

ZINC - World Drugs

STK3_HUMAN

Guide to Pharmacology - Targets

2219

OpenTargets

ENSG00000104375

ZINC - FDA approved

STK3_HUMAN

ZINC - Substances

STK3_HUMAN

ZINC target

Q13188

ZINC - Biogenic

STK3_HUMAN

PRO

Q13188

PDB

3WWS, 4LG4, 8A66, 4L0N, 4OH9, 6AR2, 5DH3, 5BRM, 4HKD, 4LGD, 6AO5

ZINC - Investigational

STK3_HUMAN

GeneCards

Q13188

HPA

ENSG00000104375-STK3

Ensembl

ENSP00000390500, ENST00000419617, ENSG00000104375, ENSP00000429744, ENST00000523601

Pharos - Targets

Q13188

ZINC - Predictions - Purchasable

STK3_HUMAN

HMDB Protein

HMDBP01454

Interactors (48)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H4B6 SAV1	2	SAV1 [cytosol] (R-HSA-2028283) p-SAV1 [cytosol] (R-HSA-2028276)	0.957	29
UniProt:P50749 RASF2			0.951	21
UniProt:Q13043 STK4	4	STK4(1-487) [cytosol] (R-HSA-201627) p-T183-STK4(1-326) [cytosol] (R-HSA-2028682) p-T183-STK4(1-487) [cytosol] (R-HSA-2028258) STK4(327-487) [cytosol] (R-HSA-2028668)	0.914	20
UniProt:Q9H2L5 RASF4			0.905	11
UniProt:Q8WWW0 RASF5			0.892	9
UniProt:Q9NS23-2 RASSF1			0.848	7
UniProt:Q9NS23 RASF1			0.827	9
UniProt:Q86WH2 RASF3			0.788	7
UniProt:Q14BN4 SLMAP			0.766	7
UniProt:Q8WWW0-1 RASSF5			0.753	6
UniProt:Q13188 STK3	4	p-T180-STK3(1-322) [cytosol] (R-HSA-2028696) STK3(323-491) [cytosol] (R-HSA-2028684) STK3(1-491) [cytosol] (R-HSA-2028280) p-T180-STK3(1-491) [cytosol] (R-HSA-2028274)	0.737	13
UniProt:Q9P0L0 VAPA	4	VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [cytosol] (R-HSA-9609920)	0.725	5
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.718	6
UniProt:Q66K74 MAP1S			0.706	5
UniProt:Q7L9L4 MOB1B	2	p-T12,T35-MOB1B [cytosol] (R-HSA-2028643) MOB1B [cytosol] (R-HSA-2028569)	0.691	9
UniProt:Q6ZTQ3 RASF6			0.659	3
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.645	6
UniProt:P46821 MAP1B	1	MAP1B(2-2206) [cytosol] (R-HSA-9836954)	0.643	3
UniProt:Q9H8S9 MOB1A	2	p-T12,T35-MOB1A [cytosol] (R-HSA-2028628) MOB1A [cytosol] (R-HSA-2028568)	0.629	7
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [cytosol] (R-HSA-5205651)	0.591	5
UniProt:Q99MK9 RASF1			0.564	2
UniProt:Q86TA1 MOB3B			0.556	3
UniProt:Q53SE7 Q53SE7			0.556	3
UniProt:P0C1Z6 TFPT	1	TFPT [nucleoplasm] (R-HSA-5689542)	0.556	3
UniProt:P0C1Z6-2 TFPT			0.556	3
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:Q8TAD8 SNIP1	1	SNIP1 [nucleoplasm] (R-HSA-3222315)	0.556	3
UniProt:Q9H8W4 PKHF2			0.556	3
UniProt:Q8IZU0 FAM9B			0.556	3
UniProt:Q99259 GAD1	2	PXLP-K405-GAD1 [plasma membrane] (R-HSA-947477) PXLP-K405-GAD1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888580)	0.556	3
UniProt:Q9H814 PHAX	2	PHAX [cytosol] (R-HSA-191804) PHAX [nucleoplasm] (R-HSA-191803)	0.547	2
UniProt:P60520 GABARAPL2	3	GABARAPL2 [autophagosome membrane] (R-HSA-5683633) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [cytosol] (R-HSA-5671758)	0.544	2
UniProt:O95166 GABARAP	3	GABARAP [autophagosome membrane] (R-HSA-5683634) GABARAP(1-117) [cytosol] (R-HSA-5682696) GABARAP [cytosol] (R-HSA-975521)	0.544	2
UniProt:Q9BXW4 MAP1LC3C	3	MAP1LC3C [autophagosome membrane] (R-HSA-5683638) MAP1LC3C(1-147) [cytosol] (R-HSA-5682653) MAP1LC3C [cytosol] (R-HSA-5679223)	0.544	2
UniProt:Q9H0R8 GABARAPL1	3	GABARAPL1 [autophagosome membrane] (R-HSA-5683637) GABARAPL1(1-117) [cytosol] (R-HSA-5682659) GABARAPL1 [cytosol] (R-HSA-5671757)	0.544	2
UniProt:P18509 ADCYAP1	4	ADCYAP1(132-158) [extracellular region] (R-HSA-420144) ADCYAP1(82-129) [extracellular region] (R-HSA-420254) ADCYAP1(132-169) [extracellular region] (R-HSA-420282) ADCYAP1(2-742) [Golgi membrane] (R-HSA-187679)	0.527	2
UniProt:Q8N4N8 KIF2B	1	KIF2B [cytosol] (R-HSA-376259)	0.527	3
UniProt:Q9NZV7 ZIM2	1	ZIM2 [nucleoplasm] (R-HSA-974996)	0.527	2
UniProt:O95292 VAPB	2	VAPB [endoplasmic reticulum membrane] (R-HSA-429718) VAPB [Golgi membrane] (R-HSA-9715115)	0.527	4
UniProt:Q13309 SKP2	3	SKP2 [cytosol] (R-HSA-975495) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [nucleoplasm] (R-HSA-975554)	0.527	2
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.527	2
UniProt:Q8TAQ5 ZNF420	2	p-S68-ZNF420 [nucleoplasm] (R-HSA-6799095) ZNF420 [nucleoplasm] (R-HSA-1247509)	0.527	2
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.483	3
UniProt:Q9Y3A3 PHOCN			0.483	3
UniProt:Q5VSL9 STRP1			0.483	3
UniProt:Q13033 STRN3			0.483	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	4
UniProt:Q9NRL3 STRN4			0.483	3

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