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STK3(323-491) [cytosol]
Stable Identifier
R-HSA-2028684
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
STK3/C, Serine/threonine-protein kinase 3 20kDa subunit, MST2/C
Locations in the PathwayBrowser for interactor UniProt:Q9P0L0 VAPA
Expand all
Signal Transduction (Homo sapiens)
Signaling by Hippo (Homo sapiens)
Cleavage of p-STK3 (p-MST2) by caspase 3 (Homo sapiens)
STK3(323-491) [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
11278283
MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation
Tsubuki, S
,
Yajima, N
,
Lee, KK
,
Ohyama, T
,
Yonehara, S
J Biol Chem
2001
External Reference Information
External Reference
UniProt:Q13188 STK3
Gene Names
STK3, KRS1, MST2
Chain
chain:1-491, chain:1-322, chain:323-491
Reference Genes
BioGPS Gene:6788 STK3
COSMIC (genes):STK3 STK3
CTD Gene:6788 STK3
dbSNP Gene:6788 STK3
ENSEMBL:ENSG00000104375 STK3
ENSEMBL_homo_sapiens_GENE:ENSG00000104375.17 STK3
HGNC:11406 STK3
KEGG Gene (Homo sapiens):6788 STK3
Monarch:6788 STK3
NCBI Gene:6788 STK3
OMIM:605030 STK3
UCSC:Q13188 STK3
Reference Transcript
RefSeq:NM_006281.3 STK3
RefSeq:NM_001256312.1 STK3
Other Identifiers
11721152_a_at
11721153_a_at
11721154_a_at
11758670_s_at
17079477
204068_PM_at
204068_at
211078_PM_s_at
211078_s_at
3146124
3146125
3146126
3146127
3146147
3146148
3146155
3146170
3146171
3146174
3146201
3146203
3146212
3146213
3146214
3146219
3146220
3146221
3146222
3146229
32142_at
6788
8151967
A_23_P215963
A_33_P3260669
GE62016
GO:0000166
GO:0000287
GO:0001841
GO:0003157
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006351
GO:0006355
GO:0006468
GO:0006606
GO:0006886
GO:0006913
GO:0006915
GO:0007165
GO:0007254
GO:0007417
GO:0008283
GO:0008285
GO:0008625
GO:0012501
GO:0016301
GO:0016310
GO:0016740
GO:0022414
GO:0023052
GO:0030154
GO:0032092
GO:0032991
GO:0035265
GO:0035329
GO:0035556
GO:0036211
GO:0042802
GO:0043065
GO:0043226
GO:0043408
GO:0043491
GO:0043539
GO:0045600
GO:0046330
GO:0046621
GO:0046872
GO:0048856
GO:0050673
GO:0050680
GO:0050821
GO:0051091
GO:0051262
GO:0051897
GO:0060070
GO:0060215
GO:0060706
GO:0060800
GO:0065003
GO:0071539
GO:0090090
GO:0097284
GO:0098772
GO:0106310
GO:0140096
GO:1902043
HMNXSV003012407
ILMN_1666453
PH_hs_0010029
TC08002442.hg
U26424_at
U60206_s_at
g405722_3p_s_at
g5454093_3p_at
Participates
as an output of
Cleavage of p-STK3 (p-MST2) by caspase 3 (Homo sapiens)
Other forms of this molecule
p-T180-STK3(1-322) [cytosol]
STK3(1-491) [cytosol]
p-T180-STK3(1-491) [cytosol]
Inferred To
Homologues of STK3(323-491) [cytosol]
(Caenorhabditis elegans)
STK3(323-491) [cytosol]
(Bos taurus)
STK3(323-491) [cytosol]
(Caenorhabditis elegans)
STK3(323-491) [cytosol]
(Danio rerio)
STK3(323-491) [cytosol]
(Drosophila melanogaster)
STK3(323-491) [cytosol]
(Mus musculus)
STK3(323-491) [cytosol]
(Rattus norvegicus)
STK3(323-491) [cytosol]
(Sus scrofa)
STK3(323-491) [cytosol]
(Xenopus tropicalis)
STK3 [cytosol]
(Canis familiaris)
STK3 [cytosol]
(Gallus gallus)
Cross References
RefSeq
NP_006272.2
,
NP_001243241.1
ZINC - World Drugs
STK3_HUMAN
Guide to Pharmacology - Targets
2219
OpenTargets
ENSG00000104375
ZINC - FDA approved
STK3_HUMAN
ZINC - Substances
STK3_HUMAN
ZINC target
Q13188
ZINC - Biogenic
STK3_HUMAN
PRO
Q13188
PDB
3WWS
,
4LG4
,
8A66
,
4L0N
,
4OH9
,
6AR2
,
5DH3
,
5BRM
,
4HKD
,
4LGD
,
6AO5
ZINC - Investigational
STK3_HUMAN
GeneCards
Q13188
HPA
ENSG00000104375-STK3
Ensembl
ENSP00000390500
,
ENST00000419617
,
ENSG00000104375
,
ENSP00000429744
,
ENST00000523601
Pharos - Targets
Q13188
ZINC - Predictions - Purchasable
STK3_HUMAN
HMDB Protein
HMDBP01454
Interactors (48)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H4B6 SAV1
2
SAV1 [cytosol]
(R-HSA-2028283)
p-SAV1 [cytosol]
(R-HSA-2028276)
0.957
29
UniProt:P50749 RASF2
0.951
21
UniProt:Q13043 STK4
4
STK4(1-487) [cytosol]
(R-HSA-201627)
p-T183-STK4(1-326) [cytosol]
(R-HSA-2028682)
p-T183-STK4(1-487) [cytosol]
(R-HSA-2028258)
STK4(327-487) [cytosol]
(R-HSA-2028668)
0.914
20
UniProt:Q9H2L5 RASF4
0.905
11
UniProt:Q8WWW0 RASF5
0.892
9
UniProt:Q9NS23-2 RASSF1
0.848
7
UniProt:Q9NS23 RASF1
0.827
9
UniProt:Q86WH2 RASF3
0.788
7
UniProt:Q14BN4 SLMAP
0.766
7
UniProt:Q8WWW0-1 RASSF5
0.753
6
UniProt:Q13188 STK3
4
p-T180-STK3(1-322) [cytosol]
(R-HSA-2028696)
STK3(323-491) [cytosol]
(R-HSA-2028684)
STK3(1-491) [cytosol]
(R-HSA-2028280)
p-T180-STK3(1-491) [cytosol]
(R-HSA-2028274)
0.737
13
UniProt:Q9P0L0 VAPA
4
VAPA [endoplasmic reticulum membrane]
(R-HSA-429677)
VAPA [azurophil granule membrane]
(R-HSA-6799364)
VAPA [plasma membrane]
(R-HSA-6806269)
VAPA [cytosol]
(R-HSA-9609920)
0.725
5
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.718
6
UniProt:Q66K74 MAP1S
0.706
5
UniProt:Q7L9L4 MOB1B
2
p-T12,T35-MOB1B [cytosol]
(R-HSA-2028643)
MOB1B [cytosol]
(R-HSA-2028569)
0.691
9
UniProt:Q6ZTQ3 RASF6
0.659
3
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.645
6
UniProt:P46821 MAP1B
1
MAP1B(2-2206) [cytosol]
(R-HSA-9836954)
0.643
3
UniProt:Q9H8S9 MOB1A
2
p-T12,T35-MOB1A [cytosol]
(R-HSA-2028628)
MOB1A [cytosol]
(R-HSA-2028568)
0.629
7
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
MAP1LC3B [cytosol]
(R-HSA-5205651)
0.591
5
UniProt:Q99MK9 RASF1
0.564
2
UniProt:Q86TA1 MOB3B
0.556
3
UniProt:Q53SE7 Q53SE7
0.556
3
UniProt:P0C1Z6 TFPT
1
TFPT [nucleoplasm]
(R-HSA-5689542)
0.556
3
UniProt:P0C1Z6-2 TFPT
0.556
3
UniProt:Q8WXH2 JPH3
0.556
3
UniProt:Q8TAD8 SNIP1
1
SNIP1 [nucleoplasm]
(R-HSA-3222315)
0.556
3
UniProt:Q9H8W4 PKHF2
0.556
3
UniProt:Q8IZU0 FAM9B
0.556
3
UniProt:Q99259 GAD1
2
PXLP-K405-GAD1 [plasma membrane]
(R-HSA-947477)
PXLP-K405-GAD1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888580)
0.556
3
UniProt:Q9H814 PHAX
2
PHAX [cytosol]
(R-HSA-191804)
PHAX [nucleoplasm]
(R-HSA-191803)
0.547
2
UniProt:P60520 GABARAPL2
3
GABARAPL2 [autophagosome membrane]
(R-HSA-5683633)
GABARAPL2(1-117) [cytosol]
(R-HSA-5682641)
GABARAPL2 [cytosol]
(R-HSA-5671758)
0.544
2
UniProt:O95166 GABARAP
3
GABARAP [autophagosome membrane]
(R-HSA-5683634)
GABARAP(1-117) [cytosol]
(R-HSA-5682696)
GABARAP [cytosol]
(R-HSA-975521)
0.544
2
UniProt:Q9BXW4 MAP1LC3C
3
MAP1LC3C [autophagosome membrane]
(R-HSA-5683638)
MAP1LC3C(1-147) [cytosol]
(R-HSA-5682653)
MAP1LC3C [cytosol]
(R-HSA-5679223)
0.544
2
UniProt:Q9H0R8 GABARAPL1
3
GABARAPL1 [autophagosome membrane]
(R-HSA-5683637)
GABARAPL1(1-117) [cytosol]
(R-HSA-5682659)
GABARAPL1 [cytosol]
(R-HSA-5671757)
0.544
2
UniProt:P18509 ADCYAP1
4
ADCYAP1(132-158) [extracellular region]
(R-HSA-420144)
ADCYAP1(82-129) [extracellular region]
(R-HSA-420254)
ADCYAP1(132-169) [extracellular region]
(R-HSA-420282)
ADCYAP1(2-742) [Golgi membrane]
(R-HSA-187679)
0.527
2
UniProt:Q8N4N8 KIF2B
1
KIF2B [cytosol]
(R-HSA-376259)
0.527
3
UniProt:Q9NZV7 ZIM2
1
ZIM2 [nucleoplasm]
(R-HSA-974996)
0.527
2
UniProt:O95292 VAPB
2
VAPB [endoplasmic reticulum membrane]
(R-HSA-429718)
VAPB [Golgi membrane]
(R-HSA-9715115)
0.527
4
UniProt:Q13309 SKP2
3
SKP2 [cytosol]
(R-HSA-975495)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
SKP2 [nucleoplasm]
(R-HSA-975554)
0.527
2
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.527
2
UniProt:Q8TAQ5 ZNF420
2
p-S68-ZNF420 [nucleoplasm]
(R-HSA-6799095)
ZNF420 [nucleoplasm]
(R-HSA-1247509)
0.527
2
UniProt:O43815 STRN
5
STRN [cytosol]
(R-HSA-9037081)
STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673902)
p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673908)
STRN(1-137)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9700485)
STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9700467)
0.483
3
UniProt:Q9Y3A3 PHOCN
0.483
3
UniProt:Q5VSL9 STRP1
0.483
3
UniProt:Q13033 STRN3
0.483
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
4
UniProt:Q9NRL3 STRN4
0.483
3
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