Reactome | p-4S-ABI2 [cytosol]

p-4S-ABI2 [cytosol]

Stable Identifier

R-HSA-2029003

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-ABI2, Abl interactor 2

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Parasite infection (Homo sapiens)
        
        Leishmania phagocytosis (Homo sapiens)
        
        FCGR3A-mediated phagocytosis (Homo sapiens)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
        
        Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
        
        WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
        
        p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
    - Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
      - Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
      - WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
      - p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
        
        Detachment of WASP/WAVE (Homo sapiens)
        
        Mother filament:branching complex [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
        
        WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)
        
        p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
        
        p-Y,S,T-WRC [cytosol] (Homo sapiens)
        
        p-ABI [cytosol] (Homo sapiens)
        
        p-4S-ABI2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NYB9 ABI2

Gene Names

ABI2, ARGBPIA

Chain

chain:1-513

Reference Genes

BioGPS Gene:10152 ABI2

COSMIC (genes):ABI2 ABI2

CTD Gene:10152 ABI2

dbSNP Gene:10152 ABI2

ENSEMBL:ENSG00000138443 ABI2

HGNC:24011 ABI2

KEGG:hsa:10152 ABI2

Monarch:10152 ABI2

NCBI Gene:10152 ABI2

OMIM:606442 ABI2

UCSC:Q9NYB9 ABI2

Reference Transcript

Participates

as a candidate of

p-ABI [cytosol] (Homo sapiens)

Other forms of this molecule

ABI2 [cytosol]

Inferred To

phospho-abi2 [cytosol] (Xenopus tropicalis)

phospho-p-4S-ABI2 [cytosol] (Gallus gallus)

phospho-Abi2 [cytosol] (Mus musculus)

phospho-Abi2 [cytosol] (Rattus norvegicus)

phospho-abi-1 [cytosol] (Caenorhabditis elegans)

phospho-abiA [cytosol] (Dictyostelium discoideum)

phospho-Abi [cytosol] (Drosophila melanogaster)

phospho-ABI2 [cytosol] (Bos taurus)

phospho-ABI2 [cytosol] (Canis familiaris)

phospho-ABI2 [cytosol] (Sus scrofa)

Modified Residues

Name

O-phospho-L-serine at 183

Coordinate

183

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 216

Coordinate

216

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 227

Coordinate

227

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 416

Coordinate

416

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001269854.1, NP_001269855.1, NP_001269856.1, NP_001362683.1, NP_005750.4, XP_006712248.1

OpenTargets

ENSG00000138443

ENSEMBL

ENSP00000261017, ENST00000261017, ENSG00000138443

HPA

ENSG00000138443-ABI2

GeneCards

ABI2

PRO

Q9NYB9

Pharos - Targets

Q9NYB9

GlyGen

Q9NYB9

PDB

4N78, 7USC, 7USD, 3P8C, 7USE, 2ED0

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.848	9
UniProt:P50552 VASP	1	VASP [cytosol] (R-HSA-446323)	0.743	6
UniProt:Q8IY31 IFT20	3	IFT20 [cilium] (R-HSA-5617624) IFT20 [Golgi membrane] (R-HSA-5617625) IFT20 [ciliary tip] (R-HSA-5625355)	0.742	6
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.742	6
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.666	5
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.666	5
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.666	5
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.666	5
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.666	5
UniProt:P61978 HNRNPK	2	HNRNPK [nucleoplasm] (R-HSA-71945) polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532)	0.666	6
UniProt:Q9UL45 BLOC1S6	1	BLOC1S6 [cytosol] (R-HSA-429816)	0.666	5
UniProt:A7KAX9 ARHGAP32	1	ARHGAP32 [cytosol] (R-HSA-195134)	0.666	4
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.643	3
UniProt:P00519 ABL1	6	p-S456-ABL1 [nucleoplasm] (R-HSA-5686576) ABL1 [nucleoplasm] (R-HSA-5686579) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [cytosol] (R-HSA-375987) p-Y393-ABL1 [cytosol] (R-HSA-9865161)	0.641	3
UniProt:P18206 VCL	8	VCL [cytosol] (R-HSA-350753) VCL [ficolin-1-rich granule lumen] (R-HSA-6800985) VCL [extracellular region] (R-HSA-350736) VCL [secretory granule lumen] (R-HSA-6801010) VCL [specific granule lumen] (R-HSA-6799711) VCL(95 kDa) [cytosol] (R-HSA-9861471) VCL(1-811)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713480) VCL(1-811)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713472)	0.553	3
UniProt:P16333 NCK1	2	NCK1 [plasma membrane] (R-HSA-202992) NCK1 [cytosol] (R-HSA-197954)	0.527	2
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.527	2
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.527	2

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