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p-4S-ABI2 [cytosol]
Stable Identifier
R-HSA-2029003
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-ABI2, Abl interactor 2
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
p-Y,S,T-WRC [cytosol] (Homo sapiens)
p-ABI [cytosol] (Homo sapiens)
p-4S-ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
p-Y,S,T-WRC [cytosol] (Homo sapiens)
p-ABI [cytosol] (Homo sapiens)
p-4S-ABI2 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
p-Y,S,T-WRC [cytosol] (Homo sapiens)
p-ABI [cytosol] (Homo sapiens)
p-4S-ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
p-Y,S,T-WRC [cytosol] (Homo sapiens)
p-ABI [cytosol] (Homo sapiens)
p-4S-ABI2 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
p-Y,S,T-WRC [cytosol] (Homo sapiens)
p-ABI [cytosol] (Homo sapiens)
p-4S-ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
p-Y,S,T-WRC [cytosol] (Homo sapiens)
p-ABI [cytosol] (Homo sapiens)
p-4S-ABI2 [cytosol] (Homo sapiens)
p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
p-Y,S,T-WRC [cytosol] (Homo sapiens)
p-ABI [cytosol] (Homo sapiens)
p-4S-ABI2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
p-Y,S,T-WRC [cytosol] (Homo sapiens)
p-ABI [cytosol] (Homo sapiens)
p-4S-ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
p-Y,S,T-WRC [cytosol] (Homo sapiens)
p-ABI [cytosol] (Homo sapiens)
p-4S-ABI2 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
p-Y,S,T-WRC [cytosol] (Homo sapiens)
p-ABI [cytosol] (Homo sapiens)
p-4S-ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
p-Y,S,T-WRC [cytosol] (Homo sapiens)
p-ABI [cytosol] (Homo sapiens)
p-4S-ABI2 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
p-Y,S,T-WRC [cytosol] (Homo sapiens)
p-ABI [cytosol] (Homo sapiens)
p-4S-ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
p-Y,S,T-WRC [cytosol] (Homo sapiens)
p-ABI [cytosol] (Homo sapiens)
p-4S-ABI2 [cytosol] (Homo sapiens)
p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
p-Y,S,T-WRC [cytosol] (Homo sapiens)
p-ABI [cytosol] (Homo sapiens)
p-4S-ABI2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
p-Y,S,T-WRC [cytosol] (Homo sapiens)
p-ABI [cytosol] (Homo sapiens)
p-4S-ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
p-Y,S,T-WRC [cytosol] (Homo sapiens)
p-ABI [cytosol] (Homo sapiens)
p-4S-ABI2 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
p-Y,S,T-WRC [cytosol] (Homo sapiens)
p-ABI [cytosol] (Homo sapiens)
p-4S-ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
p-Y,S,T-WRC [cytosol] (Homo sapiens)
p-ABI [cytosol] (Homo sapiens)
p-4S-ABI2 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
p-Y,S,T-WRC [cytosol] (Homo sapiens)
p-ABI [cytosol] (Homo sapiens)
p-4S-ABI2 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
p-Y,S,T-WRC [cytosol] (Homo sapiens)
p-ABI [cytosol] (Homo sapiens)
p-4S-ABI2 [cytosol] (Homo sapiens)
p-ERK phosphorylates WAVEs and ABI (Homo sapiens)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Homo sapiens)
p-Y,S,T-WRC [cytosol] (Homo sapiens)
p-ABI [cytosol] (Homo sapiens)
p-4S-ABI2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NYB9 ABI2
Gene Names
ABI2, ARGBPIA
Chain
chain:1-513
Reference Genes
BioGPS Gene:10152 ABI2
COSMIC (genes):ABI2 ABI2
CTD Gene:10152 ABI2
dbSNP Gene:10152 ABI2
ENSEMBL:ENSG00000138443 ABI2
HGNC:24011 ABI2
KEGG:hsa:10152 ABI2
Monarch:10152 ABI2
NCBI Gene:10152 ABI2
OMIM:606442 ABI2
UCSC:Q9NYB9 ABI2
Reference Transcript
RefSeq:NM_001375754.1 ABI2
RefSeq:NM_005759.5 ABI2
RefSeq:XM_006712185.1 ABI2
RefSeq:NM_001282925.1 ABI2
RefSeq:NM_001282927.2 ABI2
RefSeq:NM_001282926.1 ABI2
Participates
as a candidate of
p-ABI [cytosol] (Homo sapiens)
Other forms of this molecule
ABI2 [cytosol]
Inferred To
phospho-abi2 [cytosol]
(Xenopus tropicalis)
phospho-p-4S-ABI2 [cytosol]
(Gallus gallus)
phospho-Abi2 [cytosol]
(Mus musculus)
phospho-Abi2 [cytosol]
(Rattus norvegicus)
phospho-abi-1 [cytosol]
(Caenorhabditis elegans)
phospho-abiA [cytosol]
(Dictyostelium discoideum)
phospho-Abi [cytosol]
(Drosophila melanogaster)
phospho-ABI2 [cytosol]
(Bos taurus)
phospho-ABI2 [cytosol]
(Canis familiaris)
phospho-ABI2 [cytosol]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-serine at 183
Coordinate
183
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 216
Coordinate
216
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 227
Coordinate
227
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 416
Coordinate
416
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001269854.1
,
NP_001269855.1
,
NP_001269856.1
,
NP_001362683.1
,
NP_005750.4
,
XP_006712248.1
OpenTargets
ENSG00000138443
ENSEMBL
ENSP00000261017
,
ENST00000261017
,
ENSG00000138443
HPA
ENSG00000138443-ABI2
GeneCards
ABI2
PRO
Q9NYB9
Pharos - Targets
Q9NYB9
GlyGen
Q9NYB9
PDB
4N78
,
7USC
,
7USD
,
3P8C
,
7USE
,
2ED0
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.848
9
UniProt:P50552 VASP
1
VASP [cytosol]
(R-HSA-446323)
0.743
6
UniProt:Q8IY31 IFT20
3
IFT20 [cilium]
(R-HSA-5617624)
IFT20 [Golgi membrane]
(R-HSA-5617625)
IFT20 [ciliary tip]
(R-HSA-5625355)
0.742
6
UniProt:Q9UBB9 TFIP11
1
TFIP11 [nucleoplasm]
(R-HSA-8869310)
0.742
6
UniProt:P54646 PRKAA2
4
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.666
5
UniProt:Q08117 TLE5
1
AES [nucleoplasm]
(R-HSA-4648963)
0.666
5
UniProt:Q13526 PIN1
2
PIN1 [nucleoplasm]
(R-HSA-936016)
PIN1 [cytosol]
(R-HSA-9626823)
0.666
5
UniProt:O00560 SDCBP
3
SDCBP [cytosol]
(R-HSA-373639)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [extracellular region]
(R-HSA-6806206)
0.666
5
UniProt:O14964 HGS
2
HGS [cytosol]
(R-HSA-182954)
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
0.666
5
UniProt:P61978 HNRNPK
2
HNRNPK [nucleoplasm]
(R-HSA-71945)
polySUMO2-K422-HNRNPK [nucleoplasm]
(R-HSA-4570532)
0.666
6
UniProt:Q9UL45 BLOC1S6
1
BLOC1S6 [cytosol]
(R-HSA-429816)
0.666
5
UniProt:A7KAX9 ARHGAP32
1
ARHGAP32 [cytosol]
(R-HSA-195134)
0.666
4
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.643
3
UniProt:P00519 ABL1
6
p-S456-ABL1 [nucleoplasm]
(R-HSA-5686576)
ABL1 [nucleoplasm]
(R-HSA-5686579)
p-Y226,Y393-ABL1 [cytosol]
(R-HSA-8942610)
p-Y226,Y393-ABL1 [nucleoplasm]
(R-HSA-8985251)
ABL1 [cytosol]
(R-HSA-375987)
p-Y393-ABL1 [cytosol]
(R-HSA-9865161)
0.641
3
UniProt:P18206 VCL
8
VCL [cytosol]
(R-HSA-350753)
VCL [ficolin-1-rich granule lumen]
(R-HSA-6800985)
VCL [extracellular region]
(R-HSA-350736)
VCL [secretory granule lumen]
(R-HSA-6801010)
VCL [specific granule lumen]
(R-HSA-6799711)
VCL(95 kDa) [cytosol]
(R-HSA-9861471)
VCL(1-811)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713480)
VCL(1-811)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713472)
0.553
3
UniProt:P16333 NCK1
2
NCK1 [plasma membrane]
(R-HSA-202992)
NCK1 [cytosol]
(R-HSA-197954)
0.527
2
UniProt:Q9UQB8 BAIAP2
1
BAIAP2 [cytosol]
(R-HSA-442574)
0.527
2
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.527
2
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