Reactome | SNAP25 [plasma membrane]

SNAP25 [plasma membrane]

Stable Identifier

R-HSA-2029017

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Synaptosomal-associated protein 25

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P60880 SNAP25

Gene Names

SNAP25, SNAP

Chain

chain:1-206

Reference Genes

BioGPS Gene:6616 SNAP25

COSMIC (genes):SNAP25 SNAP25

CTD Gene:6616 SNAP25

dbSNP Gene:6616 SNAP25

ENSEMBL:ENSG00000132639 SNAP25

HGNC:11132 SNAP25

KEGG Gene (Homo sapiens):6616 SNAP25

Monarch:6616 SNAP25

NCBI Gene:6616 SNAP25

OMIM:600322 SNAP25

UCSC:P60880 SNAP25

Reference Transcript

Other Identifiers

0001580102

11733726_a_at

11733727_s_at

11750076_a_at

11750077_x_at

16911418

202507_s_at

202508_s_at

38484_at

3876244

3876246

3876247

3876258

3876259

3876262

3876265

3876271

3876272

3876279

3876280

3876282

3876283

3876288

3876289

6616

8060963

A_23_P210756

A_33_P3338693

D21267_at

GE61378

GO:0000149

GO:0001504

GO:0001917

GO:0002376

GO:0003674

GO:0005249

GO:0005484

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005794

GO:0005802

GO:0005829

GO:0005856

GO:0005886

GO:0006810

GO:0006887

GO:0006906

GO:0007267

GO:0007268

GO:0007269

GO:0007626

GO:0008021

GO:0008076

GO:0008150

GO:0008306

GO:0010975

GO:0014047

GO:0015031

GO:0016020

GO:0016079

GO:0016081

GO:0016082

GO:0016192

GO:0017075

GO:0019905

GO:0022607

GO:0022857

GO:0030054

GO:0030154

GO:0030424

GO:0030426

GO:0030674

GO:0031083

GO:0031201

GO:0031234

GO:0031410

GO:0031629

GO:0031982

GO:0032991

GO:0035579

GO:0036477

GO:0042734

GO:0043005

GO:0043226

GO:0043312

GO:0045202

GO:0048306

GO:0048471

GO:0048856

GO:0050796

GO:0050877

GO:0055085

GO:0060291

GO:0061024

GO:0065003

GO:0070032

GO:0070201

GO:0070821

GO:0071805

GO:0098794

GO:0098967

GO:0098978

GO:0099590

ILMN_1740555

ILMN_2408080

PH_hs_0023120

TC20000082.hg

g307425_3p_a_at

g4507098_3p_a_at

Participant Of

hasComponent

input

hasMember

Other forms of this molecule

SNAP25(1-197) [plasma membrane]

SNAP25(198-206) [cytosol]

SNAP25(1-198) [plasma membrane]

SNAP25(199-206) [cytosol]

SNAP25 [specific granule membrane]

SNAP25 [tertiary granule membrane]

Inferred To

SEC9 [plasma membrane] (Saccharomyces cerevisiae)

snap25a [plasma membrane] (Danio rerio)

SNAP25 [plasma membrane] (Canis familiaris)

SNAP25 [plasma membrane] (Dictyostelium discoideum)

SNAP25 [plasma membrane] (Gallus gallus)

SNAP25 [plasma membrane] (Plasmodium falciparum)

SNAP25 [plasma membrane] (Sus scrofa)

Homologues of SNAP25 [plasma membrane] (Caenorhabditis elegans)

Homologues of SNAP25 [plasma membrane] (Dictyostelium discoideum)

Homologues of SNAP25 [plasma membrane] (Drosophila melanogaster)

Homologues of SNAP25 [plasma membrane] (Saccharomyces cerevisiae)

SPO20 [plasma membrane] (Saccharomyces cerevisiae)

Snap24 [plasma membrane] (Drosophila melanogaster)

aex-4 [plasma membrane] (Caenorhabditis elegans)

culC [plasma membrane] (Dictyostelium discoideum)

Snap25 [plasma membrane] (Drosophila melanogaster)

Snap25 [plasma membrane] (Mus musculus)

Snap25 [plasma membrane] (Rattus norvegicus)

ric-4 [plasma membrane] (Caenorhabditis elegans)

sec9 [plasma membrane] (Schizosaccharomyces pombe)

snap25 [plasma membrane] (Xenopus tropicalis)

Modified Residues

Name

S-palmitoyl-L-cysteine at 85

Coordinate

PsiMod Name

S-palmitoyl-L-cysteine [MOD:00115]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.

Name

S-palmitoyl-L-cysteine at 88

Coordinate

PsiMod Name

S-palmitoyl-L-cysteine [MOD:00115]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.

Name

S-palmitoyl-L-cysteine at 90

Coordinate

PsiMod Name

S-palmitoyl-L-cysteine [MOD:00115]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.

Name

S-palmitoyl-L-cysteine at 92

Coordinate

PsiMod Name

S-palmitoyl-L-cysteine [MOD:00115]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.

Cross References

RefSeq

XP_016883510.1, XP_016883511.1, NP_001309839.1, NP_001309835.1, NP_001309836.1, NP_001309832.1, NP_001309831.1, NP_003072.2, XP_005260865.1, NP_570824.1, NP_001309837.1, NP_001309838.1, NP_001309834.1, NP_001309833.1

OpenTargets

ENSG00000132639

HPA

ENSG00000132639-SNAP25

GeneCards

P60880

Ensembl

ENSG00000132639, ENST00000304886, ENSP00000254976, ENSP00000307341, ENST00000254976

PRO

P60880

Orphanet

23214

HMDB Protein

HMDBP02940

PDB

3RK2, 1XTG, 3RK3, 3ZUR, 5W7I, 2N1T, 3DDB, 3RL0, 5W7J, 3DDA, 6JLH, 1KIL

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75558 STX11			0.553	2
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.553	2
UniProt:Q8IUH5 ZDH17			0.489	3
UniProt:Q9Y3C0 WASC3			0.488	2

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