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SNAP25 [plasma membrane]
Stable Identifier
R-HSA-2029017
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Synaptosomal-associated protein 25
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Uptake and actions of bacterial toxins (Homo sapiens)
Neurotoxicity of clostridium toxins (Homo sapiens)
Toxicity of botulinum toxin type A (botA) (Homo sapiens)
botA LC cleaves target cell SNAP25 (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Toxicity of botulinum toxin type C (botC) (Homo sapiens)
botC LC cleaves target cell SNAP25 (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Toxicity of botulinum toxin type E (botE) (Homo sapiens)
botE LC cleaves target cell SNAP25 (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Other interleukin signaling (Homo sapiens)
TXLNA (IL14) binds syntaxin1A (Homo sapiens)
STXA1:SNAP25,STXBP2, VAMP2 [plasma membrane] (Homo sapiens)
SNAP25,STXBP2, VAMP2 [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of specific granule membrane proteins (Homo sapiens)
Specific granule membrane proteins [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Exocytosis of tertiary granule membrane proteins (Homo sapiens)
Tertiary granule membrane proteins [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Exocytosis of Insulin (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNARE Complex [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
Acetylcholine Neurotransmitter Release Cycle (Homo sapiens)
Acetylcholine synaptic vesicle docking and priming (Homo sapiens)
Docked acetylcholine loaded Synaptic Vesicle [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Release of acetylcholine at the synapse (Homo sapiens)
Docked acetylcholine loaded Synaptic Vesicle [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNARE complex [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Dopamine Neurotransmitter Release Cycle (Homo sapiens)
Dopamine synaptic vesicle docking and priming (Homo sapiens)
Docked dopamine loaded synaptic vesicle [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Release of docked dopamine loaded synaptic vesicle (Homo sapiens)
Docked dopamine loaded synaptic vesicle [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNARE complex [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
GABA synthesis, release, reuptake and degradation (Homo sapiens)
GABA loaded synaptic vesicle Docking and Priming (Homo sapiens)
Docked GABA loaded synaptic vesicle [cytosol] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Release of GABA at the synapse (Homo sapiens)
Docked GABA loaded synaptic vesicle [cytosol] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNARE complex:Ca2+ [plasma membrane] (Homo sapiens)
SNARE complex [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Glutamate Neurotransmitter Release Cycle (Homo sapiens)
Glutamate synaptic vesicle docking and priming (Homo sapiens)
Docked Glutamate Loaded Synaptic Vesicle [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Release of L-Glutamate at the synapse (Homo sapiens)
Docked Glutamate Loaded Synaptic Vesicle [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNARE complex:Ca2+ [plasma membrane] (Homo sapiens)
SNARE complex [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Norepinephrine Neurotransmitter Release Cycle (Homo sapiens)
Noradrenalin synaptic vesicle docking and priming (Homo sapiens)
Docked Noradrenalin loaded synaptic vesicle [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Release of noradrenaline at the synapse (Homo sapiens)
Docked Noradrenalin loaded synaptic vesicle [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNARE complex [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Serotonin Neurotransmitter Release Cycle (Homo sapiens)
Release of docked serotonin loaded synaptic vesicle (Homo sapiens)
Docked serotonin loaded synaptic vesicle [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNARE complex [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Serotonin loaded synaptic vesicle docking and priming (Homo sapiens)
Docked serotonin loaded synaptic vesicle [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Sensory Perception (Homo sapiens)
Sensory processing of sound (Homo sapiens)
Sensory processing of sound by inner hair cells of the cochlea (Homo sapiens)
Exocytosis of glutamate from cochlear inner hair cell (Homo sapiens)
Glutamate depleted vesicle:Ca2+:SNAP25:STX1A [plasma membrane] (Homo sapiens)
SNAP25:STX1A [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNAP25:STX1A [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P60880 SNAP25
Gene Names
SNAP25, SNAP
Chain
chain:1-206
Reference Genes
COSMIC (genes):SNAP25 SNAP25
dbSNP Gene:6616 SNAP25
ENSEMBL:ENSG00000132639 SNAP25
Participates
as a component of
SNAP25:STX1A [plasma membrane] (Homo sapiens)
SNARE Complex [plasma membrane] (Homo sapiens)
Docked serotonin loaded synaptic vesicle [plasma membrane] (Homo sapiens)
SNARE complex [plasma membrane] (Homo sapiens)
Docked GABA loaded synaptic vesicle [cytosol] (Homo sapiens)
Docked Glutamate Loaded Synaptic Vesicle [plasma membrane] (Homo sapiens)
Docked Noradrenalin loaded synaptic vesicle [plasma membrane] (Homo sapiens)
Docked acetylcholine loaded Synaptic Vesicle [plasma membrane] (Homo sapiens)
Docked dopamine loaded synaptic vesicle [plasma membrane] (Homo sapiens)
as an input of
Exocytosis of Insulin (Homo sapiens)
botC LC cleaves target cell SNAP25 (Homo sapiens)
Serotonin loaded synaptic vesicle docking and priming (Homo sapiens)
GABA loaded synaptic vesicle Docking and Priming (Homo sapiens)
Glutamate synaptic vesicle docking and priming (Homo sapiens)
Noradrenalin synaptic vesicle docking and priming (Homo sapiens)
Acetylcholine synaptic vesicle docking and priming (Homo sapiens)
Dopamine synaptic vesicle docking and priming (Homo sapiens)
botE LC cleaves target cell SNAP25 (Homo sapiens)
botA LC cleaves target cell SNAP25 (Homo sapiens)
as a member of
SNAP25,STXBP2, VAMP2 [plasma membrane] (Homo sapiens)
Specific granule membrane proteins [plasma membrane] (Homo sapiens)
Tertiary granule membrane proteins [plasma membrane] (Homo sapiens)
Other forms of this molecule
SNAP25(1-197) [plasma membrane]
SNAP25(198-206) [cytosol]
SNAP25(1-198) [plasma membrane]
SNAP25(199-206) [cytosol]
SNAP25 [tertiary granule membrane]
SNAP25 [specific granule membrane]
Inferred To
SEC9 [plasma membrane]
(Saccharomyces cerevisiae)
snap25a [plasma membrane]
(Danio rerio)
SNAP25 [plasma membrane]
(Bos taurus)
SNAP25 [plasma membrane]
(Canis familiaris)
SNAP25 [plasma membrane]
(Dictyostelium discoideum)
SNAP25 [plasma membrane]
(Gallus gallus)
SNAP25 [plasma membrane]
(Plasmodium falciparum)
SNAP25 [plasma membrane]
(Sus scrofa)
Homologues of SNAP25 [plasma membrane]
(Caenorhabditis elegans)
Homologues of SNAP25 [plasma membrane]
(Dictyostelium discoideum)
Homologues of SNAP25 [plasma membrane]
(Drosophila melanogaster)
Homologues of SNAP25 [plasma membrane]
(Saccharomyces cerevisiae)
cspA [plasma membrane]
(Dictyostelium discoideum)
SPO20 [plasma membrane]
(Saccharomyces cerevisiae)
Snap24 [plasma membrane]
(Drosophila melanogaster)
aex-4 [plasma membrane]
(Caenorhabditis elegans)
Snap25 [plasma membrane]
(Drosophila melanogaster)
Snap25 [plasma membrane]
(Mus musculus)
Snap25 [plasma membrane]
(Rattus norvegicus)
ric-4 [plasma membrane]
(Caenorhabditis elegans)
sec9 [plasma membrane]
(Schizosaccharomyces pombe)
snap25 [plasma membrane]
(Xenopus tropicalis)
Modified Residues
Name
S-palmitoyl-L-cysteine at 85
Coordinate
85
PsiMod Name
S-palmitoyl-L-cysteine [MOD:00115]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.
Name
S-palmitoyl-L-cysteine at 88
Coordinate
88
PsiMod Name
S-palmitoyl-L-cysteine [MOD:00115]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.
Name
S-palmitoyl-L-cysteine at 90
Coordinate
90
PsiMod Name
S-palmitoyl-L-cysteine [MOD:00115]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.
Name
S-palmitoyl-L-cysteine at 92
Coordinate
92
PsiMod Name
S-palmitoyl-L-cysteine [MOD:00115]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0DTD1-PRO_0000449622 REP
0.556
3
UniProt:O75558 STX11
0.553
2
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:Q16623 STX1A
5
STX1A [plasma membrane]
(R-HSA-449128)
STX1A(?-288) [plasma membrane]
(R-HSA-5246518)
STX1A(1-?) [cytosol]
(R-HSA-3065964)
STX1A [cytosol]
(R-HSA-9609866)
STX1A [endoplasmic reticulum membrane]
(R-HSA-9609878)
0.547
3
UniProt:P61764 STXBP1
2
STXBP1 [plasma membrane]
(R-HSA-2980862)
STXBP1 [cytosol]
(R-HSA-6794256)
0.527
2
UniProt:P84077 ARF1
2
ARF1 [Golgi membrane]
(R-HSA-199971)
ARF1 [cytosol]
(R-HSA-200826)
0.512
5
UniProt:Q15811 ITSN1
1
ITSN1 [cytosol]
(R-HSA-3006481)
0.502
2
UniProt:Q8IUH5 ZDH17
0.489
3
UniProt:Q9Y3C0 WASC3
0.488
2
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