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SNAP25 [plasma membrane]
Stable Identifier
R-HSA-2029017
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Synaptosomal-associated protein 25
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Uptake and actions of bacterial toxins (Homo sapiens)
Neurotoxicity of clostridium toxins (Homo sapiens)
Toxicity of botulinum toxin type A (botA) (Homo sapiens)
botA LC cleaves target cell SNAP25 (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Toxicity of botulinum toxin type C (botC) (Homo sapiens)
botC LC cleaves target cell SNAP25 (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Toxicity of botulinum toxin type E (botE) (Homo sapiens)
botE LC cleaves target cell SNAP25 (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Other interleukin signaling (Homo sapiens)
TXLNA (IL14) binds syntaxin1A (Homo sapiens)
STXA1:SNAP25,STXBP2, VAMP2 [plasma membrane] (Homo sapiens)
SNAP25,STXBP2, VAMP2 [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of specific granule membrane proteins (Homo sapiens)
Specific granule membrane proteins [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Exocytosis of tertiary granule membrane proteins (Homo sapiens)
Tertiary granule membrane proteins [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Exocytosis of Insulin (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNARE Complex [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
Acetylcholine Neurotransmitter Release Cycle (Homo sapiens)
Acetylcholine synaptic vesicle docking and priming (Homo sapiens)
Docked acetylcholine loaded Synaptic Vesicle [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Release of acetylcholine at the synapse (Homo sapiens)
Docked acetylcholine loaded Synaptic Vesicle [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNARE complex [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Dopamine Neurotransmitter Release Cycle (Homo sapiens)
Dopamine synaptic vesicle docking and priming (Homo sapiens)
Docked dopamine loaded synaptic vesicle [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Release of docked dopamine loaded synaptic vesicle (Homo sapiens)
Docked dopamine loaded synaptic vesicle [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNARE complex [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
GABA synthesis, release, reuptake and degradation (Homo sapiens)
GABA loaded synaptic vesicle Docking and Priming (Homo sapiens)
Docked GABA loaded synaptic vesicle [cytosol] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Release of GABA at the synapse (Homo sapiens)
Docked GABA loaded synaptic vesicle [cytosol] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNARE complex:Ca2+ [plasma membrane] (Homo sapiens)
SNARE complex [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Glutamate Neurotransmitter Release Cycle (Homo sapiens)
Glutamate synaptic vesicle docking and priming (Homo sapiens)
Docked Glutamate Loaded Synaptic Vesicle [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Release of L-Glutamate at the synapse (Homo sapiens)
Docked Glutamate Loaded Synaptic Vesicle [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNARE complex:Ca2+ [plasma membrane] (Homo sapiens)
SNARE complex [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Norepinephrine Neurotransmitter Release Cycle (Homo sapiens)
Noradrenalin synaptic vesicle docking and priming (Homo sapiens)
Docked Noradrenalin loaded synaptic vesicle [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Release of noradrenaline at the synapse (Homo sapiens)
Docked Noradrenalin loaded synaptic vesicle [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNARE complex [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Serotonin Neurotransmitter Release Cycle (Homo sapiens)
Release of docked serotonin loaded synaptic vesicle (Homo sapiens)
Docked serotonin loaded synaptic vesicle [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNARE complex [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
Serotonin loaded synaptic vesicle docking and priming (Homo sapiens)
Docked serotonin loaded synaptic vesicle [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
SNAP25 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P60880 SNAP25
Gene Names
SNAP25, SNAP
Chain
chain:1-206
Reference Genes
BioGPS Gene:6616 SNAP25
COSMIC (genes):SNAP25 SNAP25
CTD Gene:6616 SNAP25
dbSNP Gene:6616 SNAP25
ENSEMBL:ENSG00000132639 SNAP25
HGNC:11132 SNAP25
KEGG Gene (Homo sapiens):6616 SNAP25
Monarch:6616 SNAP25
NCBI Gene:6616 SNAP25
OMIM:600322 SNAP25
UCSC:P60880 SNAP25
Reference Transcript
RefSeq:XM_017028021.1 SNAP25
RefSeq:NM_001322908.1 SNAP25
RefSeq:NM_001322909.1 SNAP25
RefSeq:NM_001322906.1 SNAP25
RefSeq:XM_005260808.4 SNAP25
RefSeq:NM_001322907.1 SNAP25
RefSeq:NM_001322905.1 SNAP25
RefSeq:NM_001322904.1 SNAP25
RefSeq:NM_003081.4 SNAP25
RefSeq:XM_017028022.1 SNAP25
RefSeq:NM_001322903.1 SNAP25
RefSeq:NM_001322910.1 SNAP25
RefSeq:NM_130811.3 SNAP25
RefSeq:NM_001322902.1 SNAP25
Other Identifiers
0001580102
11733726_a_at
11733727_s_at
11750076_a_at
11750077_x_at
16911418
202507_s_at
202508_s_at
38484_at
3876244
3876246
3876247
3876258
3876259
3876262
3876265
3876271
3876272
3876279
3876280
3876282
3876283
3876288
3876289
6616
8060963
A_23_P210756
A_33_P3338693
D21267_at
GE61378
GO:0000149
GO:0001504
GO:0001917
GO:0002376
GO:0003674
GO:0005249
GO:0005484
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005794
GO:0005802
GO:0005829
GO:0005856
GO:0005886
GO:0006810
GO:0006887
GO:0006906
GO:0007267
GO:0007268
GO:0007269
GO:0007626
GO:0008021
GO:0008076
GO:0008150
GO:0008306
GO:0010975
GO:0014047
GO:0015031
GO:0016020
GO:0016079
GO:0016081
GO:0016082
GO:0016192
GO:0017075
GO:0019905
GO:0022607
GO:0022857
GO:0030054
GO:0030154
GO:0030424
GO:0030426
GO:0030674
GO:0031083
GO:0031201
GO:0031234
GO:0031410
GO:0031629
GO:0031982
GO:0032991
GO:0035579
GO:0036477
GO:0042734
GO:0043005
GO:0043226
GO:0043312
GO:0045202
GO:0048306
GO:0048471
GO:0048856
GO:0050796
GO:0050877
GO:0055085
GO:0060291
GO:0061024
GO:0065003
GO:0070032
GO:0070201
GO:0070821
GO:0071805
GO:0098794
GO:0098967
GO:0098978
GO:0099590
ILMN_1740555
ILMN_2408080
PH_hs_0023120
TC20000082.hg
g307425_3p_a_at
g4507098_3p_a_at
Participant Of
hasComponent
Docked acetylcholine loaded Synaptic Vesicle [plasma membrane]
Docked dopamine loaded synaptic vesicle [plasma membrane]
Docked GABA loaded synaptic vesicle [cytosol]
Docked Glutamate Loaded Synaptic Vesicle [plasma membrane]
Docked Noradrenalin loaded synaptic vesicle [plasma membrane]
Docked serotonin loaded synaptic vesicle [plasma membrane]
SNARE complex [plasma membrane]
SNARE Complex [plasma membrane]
input
Acetylcholine synaptic vesicle docking and priming
botA LC cleaves target cell SNAP25
botC LC cleaves target cell SNAP25
botE LC cleaves target cell SNAP25
Dopamine synaptic vesicle docking and priming
Exocytosis of Insulin
GABA loaded synaptic vesicle Docking and Priming
Glutamate synaptic vesicle docking and priming
Noradrenalin synaptic vesicle docking and priming
Serotonin loaded synaptic vesicle docking and priming
hasMember
SNAP25,STXBP2, VAMP2 [plasma membrane]
Specific granule membrane proteins [plasma membrane]
Tertiary granule membrane proteins [plasma membrane]
Other forms of this molecule
SNAP25(1-197) [plasma membrane]
SNAP25(198-206) [cytosol]
SNAP25(1-198) [plasma membrane]
SNAP25(199-206) [cytosol]
SNAP25 [specific granule membrane]
SNAP25 [tertiary granule membrane]
Inferred To
SEC9 [plasma membrane] (Saccharomyces cerevisiae)
snap25a [plasma membrane] (Danio rerio)
SNAP25 [plasma membrane] (Canis familiaris)
SNAP25 [plasma membrane] (Dictyostelium discoideum)
SNAP25 [plasma membrane] (Gallus gallus)
SNAP25 [plasma membrane] (Plasmodium falciparum)
SNAP25 [plasma membrane] (Sus scrofa)
Homologues of SNAP25 [plasma membrane] (Caenorhabditis elegans)
Homologues of SNAP25 [plasma membrane] (Dictyostelium discoideum)
Homologues of SNAP25 [plasma membrane] (Drosophila melanogaster)
Homologues of SNAP25 [plasma membrane] (Saccharomyces cerevisiae)
SPO20 [plasma membrane] (Saccharomyces cerevisiae)
Snap24 [plasma membrane] (Drosophila melanogaster)
aex-4 [plasma membrane] (Caenorhabditis elegans)
culC [plasma membrane] (Dictyostelium discoideum)
Snap25 [plasma membrane] (Drosophila melanogaster)
Snap25 [plasma membrane] (Mus musculus)
Snap25 [plasma membrane] (Rattus norvegicus)
ric-4 [plasma membrane] (Caenorhabditis elegans)
sec9 [plasma membrane] (Schizosaccharomyces pombe)
snap25 [plasma membrane] (Xenopus tropicalis)
Modified Residues
Name
S-palmitoyl-L-cysteine at 85
Coordinate
85
PsiMod Name
S-palmitoyl-L-cysteine [MOD:00115]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.
Name
S-palmitoyl-L-cysteine at 88
Coordinate
88
PsiMod Name
S-palmitoyl-L-cysteine [MOD:00115]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.
Name
S-palmitoyl-L-cysteine at 90
Coordinate
90
PsiMod Name
S-palmitoyl-L-cysteine [MOD:00115]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.
Name
S-palmitoyl-L-cysteine at 92
Coordinate
92
PsiMod Name
S-palmitoyl-L-cysteine [MOD:00115]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.
Cross References
RefSeq
XP_016883510.1
,
XP_016883511.1
,
NP_001309839.1
,
NP_001309835.1
,
NP_001309836.1
,
NP_001309832.1
,
NP_001309831.1
,
NP_003072.2
,
XP_005260865.1
,
NP_570824.1
,
NP_001309837.1
,
NP_001309838.1
,
NP_001309834.1
,
NP_001309833.1
OpenTargets
ENSG00000132639
HPA
ENSG00000132639-SNAP25
GeneCards
P60880
Ensembl
ENSG00000132639
,
ENST00000304886
,
ENSP00000254976
,
ENSP00000307341
,
ENST00000254976
PRO
P60880
Orphanet
23214
HMDB Protein
HMDBP02940
PDB
3RK2
,
1XTG
,
3RK3
,
3ZUR
,
5W7I
,
2N1T
,
3DDB
,
3RL0
,
5W7J
,
3DDA
,
6JLH
,
1KIL
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75558 STX11
0.553
2
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.553
2
UniProt:Q8IUH5 ZDH17
0.489
3
UniProt:Q9Y3C0 WASC3
0.488
2
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