Reactome | ARF6 [recycling endosome membrane]

ARF6 [recycling endosome membrane]

Stable Identifier

R-HSA-2029049

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

recycling endosome membrane

Synonyms

ADP-ribosylation factor 6, ARF6_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P62330 ARF6

Gene Names

ARF6

Chain

initiator methionine:1, chain:2-175

Reference Genes

BioGPS Gene:382 ARF6

COSMIC (genes):ARF6 ARF6

CTD Gene:382 ARF6

dbSNP Gene:382 ARF6

ENSEMBL:ENSG00000165527 ARF6

HGNC:659 ARF6

KEGG Gene (Homo sapiens):382 ARF6

Monarch:382 ARF6

NCBI Gene:382 ARF6

OMIM:600464 ARF6

UCSC:P62330 ARF6

Reference Transcript

RefSeq:NM_001663.3 ARF6

Other Identifiers

11717401_at

11717402_s_at

11758273_s_at

16783974

203311_s_at

203312_x_at

224788_at

2631342

3063398

3063399

33152_at

3535001

3535004

3535005

3535006

3535007

3535008

3535009

3535010

382

43480_at

54829_s_at

54831_r_at

7974249

A_14_P107803

A_23_P48691

A_24_P472455

GE58261

GO:0000166

GO:0001726

GO:0001889

GO:0003674

GO:0003924

GO:0005515

GO:0005525

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005768

GO:0005769

GO:0005794

GO:0005829

GO:0005886

GO:0005925

GO:0005938

GO:0006810

GO:0006886

GO:0007010

GO:0007049

GO:0007155

GO:0007165

GO:0007399

GO:0008150

GO:0008219

GO:0010008

GO:0010975

GO:0015031

GO:0016020

GO:0016192

GO:0019899

GO:0022607

GO:0030139

GO:0030154

GO:0030838

GO:0030866

GO:0031410

GO:0031527

GO:0031901

GO:0031996

GO:0032154

GO:0032456

GO:0033028

GO:0034330

GO:0034394

GO:0035020

GO:0036010

GO:0040011

GO:0042995

GO:0043167

GO:0043226

GO:0047485

GO:0048261

GO:0048488

GO:0048856

GO:0048870

GO:0050714

GO:0051301

GO:0051489

GO:0051549

GO:0055037

GO:0055038

GO:0060998

GO:0065003

GO:0070062

GO:0090162

GO:0090543

GO:0097178

GO:0097284

GO:0098793

GO:0098978

GO:0099562

GO:0120183

GO:1903078

GO:1990090

GO:2000009

GO:2000171

Hs.180777.0.A1_3p_at

M57763_at

TC14000280.hg

TC14001678.hg

g178988_3p_a_at

g6996000_3p_a_at

Participant Of

hasComponent

ARF6:GTP [recycling endosome membrane]

Other forms of this molecule

ARF6 [cytosol]

Inferred To

Arf6 [recycling endosome membrane] (Mus musculus)

Arf6 [recycling endosome membrane] (Rattus norvegicus)

ARF6 [recycling endosome membrane] (Bos taurus)

ARF6 [recycling endosome membrane] (Canis familiaris)

ARF6 [recycling endosome membrane] (Sus scrofa)

ARF6 [recycling endosome membrane] (Xenopus tropicalis)

Ghost homologue of ARF6 [recycling endosome membrane] (Gallus gallus)

arf6b [recycling endosome membrane] (Danio rerio)

ARF3 [recycling endosome membrane] (Saccharomyces cerevisiae)

arf6 [recycling endosome membrane] (Schizosaccharomyces pombe)

Arf51F [recycling endosome membrane] (Drosophila melanogaster)

arf-6 [recycling endosome membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001654.1

OpenTargets

ENSG00000165527

GeneCards

P62330

HPA

ENSG00000165527-ARF6

Ensembl

ENSG00000165527, ENSP00000298316, ENST00000298316

PRO

P62330

HMDB Protein

HMDBP08304

PDB

4KAX, 3LVQ, 2BAU, 6BBQ, 2A5F, 2W83, 2A5G, 2BAO, 3N5C, 1E0S, 6BBP, 3PCR, 6PAU, 3LVR, 2A5D, 2J5X, 4FME

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q02241 KIF23	3	p-S904,S905-KIF23 [nucleoplasm] (R-HSA-156695) KIF23 [nucleoplasm] (R-HSA-156709) KIF23 [cytosol] (R-HSA-1015863)	0.667	23
UniProt:O00213 APBB1	1	APBB1 [nucleoplasm] (R-HSA-5683987)	0.633	9
UniProt:O60271 SPAG9	1	SPAG9 [cytosol] (R-HSA-375975)	0.618	8
UniProt:Q9NZ52 GGA3	3	GGA3 [recycling endosome membrane] (R-HSA-8875655) GGA3 [endosome membrane] (R-HSA-5692936) GGA3 [early endosome membrane] (R-HSA-8854137)	0.589	3
UniProt:P53365 ARFIP2	1	ARFIP2 [cytosol] (R-HSA-6813848)	0.57	4
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.553	2

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