Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
DCTN4 [cytosol]
Stable Identifier
R-HSA-2029070
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Dynactin subunit 4, DCTN4_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Homo sapiens)
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
Pointed end complex [cytosol] (Homo sapiens)
DCTN4 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
MHC class II antigen presentation (Homo sapiens)
Transport of antigen loaded MHC II molecules to surface (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
Pointed end complex [cytosol] (Homo sapiens)
DCTN4 [cytosol] (Homo sapiens)
Kinesins:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
Pointed end complex [cytosol] (Homo sapiens)
DCTN4 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
Pointed end complex [cytosol] (Homo sapiens)
DCTN4 [cytosol] (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
Pointed end complex [cytosol] (Homo sapiens)
DCTN4 [cytosol] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
Pointed end complex [cytosol] (Homo sapiens)
DCTN4 [cytosol] (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
Pointed end complex [cytosol] (Homo sapiens)
DCTN4 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
Pointed end complex [cytosol] (Homo sapiens)
DCTN4 [cytosol] (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
Pointed end complex [cytosol] (Homo sapiens)
DCTN4 [cytosol] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
Pointed end complex [cytosol] (Homo sapiens)
DCTN4 [cytosol] (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
Pointed end complex [cytosol] (Homo sapiens)
DCTN4 [cytosol] (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Golgi-to-ER retrograde transport (Homo sapiens)
COPI-independent Golgi-to-ER retrograde traffic (Homo sapiens)
Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
Pointed end complex [cytosol] (Homo sapiens)
DCTN4 [cytosol] (Homo sapiens)
RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
Pointed end complex [cytosol] (Homo sapiens)
DCTN4 [cytosol] (Homo sapiens)
RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Homo sapiens)
Dynein:Dynactin:microtubules:PAFAH1B1 [cytosol] (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
Pointed end complex [cytosol] (Homo sapiens)
DCTN4 [cytosol] (Homo sapiens)
RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Homo sapiens)
Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
Dynactin [cytosol] (Homo sapiens)
Dynactin rod [cytosol] (Homo sapiens)
ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Homo sapiens)
Pointed end complex [cytosol] (Homo sapiens)
DCTN4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UJW0 DCTN4
Gene Names
DCTN4
Chain
initiator methionine:, chain:2-460
Reference Genes
BioGPS Gene:51164 DCTN4
COSMIC (genes):DCTN4 DCTN4
CTD Gene:51164 DCTN4
dbSNP Gene:51164 DCTN4
ENSEMBL:ENSG00000132912 DCTN4
HGNC:15518 DCTN4
KEGG:hsa:51164 DCTN4
Monarch:51164 DCTN4
NCBI Gene:51164 DCTN4
OMIM:614758 DCTN4
UCSC:Q9UJW0 DCTN4
Reference Transcript
RefSeq:NM_001135644.1 DCTN4
RefSeq:XM_011537644.1 DCTN4
RefSeq:NM_001135643.1 DCTN4
RefSeq:NM_016221.3 DCTN4
RefSeq:XM_011537645.1 DCTN4
Other Identifiers
11718742_s_at
11734569_a_at
11734570_s_at
11734571_x_at
11749838_a_at
11751475_a_at
17001718
218013_PM_x_at
218013_x_at
222488_PM_s_at
222488_s_at
231055_PM_at
231055_at
233490_PM_at
233490_at
2881550
2881552
2881553
2881555
2881556
2881557
2881558
2881559
2881560
2881561
2881563
2881564
2881565
2881569
2881571
2881572
2881573
2881574
2881575
2881576
2881577
2881579
2881580
2881581
2881582
2881583
2881584
2881585
2881586
3054395
43847_s_at
51164
65917_at
73429_at
77228_at
8115181
83502_at
A_23_P251945
A_32_P122951
GE55433
GO:0000776
GO:0000922
GO:0001725
GO:0005515
GO:0005634
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005868
GO:0005869
GO:0005925
GO:0005938
GO:0030017
GO:0043226
HMNXSV003017364
Hs.180952.0.A2_3p_a_at
Hs.180952.2.A1_3p_a_at
Hs.263462.0.A1_3p_at
PH_hs_0016236
TC05001943.hg
g7705892_3p_a_at
Participates
as a component of
Pointed end complex [cytosol] (Homo sapiens)
Inferred To
dnc-4 [cytosol]
(Caenorhabditis elegans)
Dctn4 [cytosol]
(Mus musculus)
Dctn4 [cytosol]
(Rattus norvegicus)
dynD [cytosol]
(Dictyostelium discoideum)
DCTN4 [cytosol]
(Bos taurus)
DCTN4 [cytosol]
(Canis familiaris)
DCTN4 [cytosol]
(Gallus gallus)
DCTN4 [cytosol]
(Plasmodium falciparum)
DCTN4 [cytosol]
(Sus scrofa)
dctn4 [cytosol]
(Xenopus tropicalis)
DCTN4-p62 [cytosol]
(Drosophila melanogaster)
Cross References
ENSEMBL
ENSP00000414906
,
ENSP00000411251
,
ENST00000446090
,
ENST00000447998
,
ENSP00000416968
,
ENST00000424236
OpenTargets
ENSG00000132912
HPA
ENSG00000132912-DCTN4
PRO
Q9UJW0
Pharos - Targets
Q9UJW0
GlyGen
Q9UJW0
Orphanet
DCTN4
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.781
7
UniProt:Q14203 DCTN1
7
DCTN1(1-1065)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711969)
DCTN1(1-599)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711960)
DCTN1(1-1177)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9701997)
DCTN1(1-1065)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711959)
DCTN1(1-599)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711953)
DCTN1(1-1177)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711962)
DCTN1 [cytosol]
(R-HSA-535580)
0.712
7
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
8
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:P47756 CAPZB
1
CAPZB [cytosol]
(R-HSA-879409)
0.527
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text