Reactome | BIRC2(1-372) [cytosol]

BIRC2(1-372) [cytosol]

Stable Identifier

R-HSA-202913

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

C-IAP1(1-372)

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Locations in the PathwayBrowser for interactor UniProt:Q9Y3E2 BOLA1

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External Reference Information

External Reference

UniProt:Q13490 BIRC2

Gene Names

BIRC2, API1, MIHB, RNF48

Chain

chain:1-618

Reference Genes

BioGPS Gene:329 BIRC2

COSMIC (genes):BIRC2 BIRC2

CTD Gene:329 BIRC2

dbSNP Gene:329 BIRC2

ENSEMBL:ENSG00000110330 BIRC2

HGNC:590 BIRC2

KEGG Gene (Homo sapiens):329 BIRC2

Monarch:329 BIRC2

NCBI Gene:329 BIRC2

OMIM:601712 BIRC2

UCSC:Q13490 BIRC2

Reference Transcript

Other Identifiers

0001740300

11717627_a_at

11717628_a_at

11744694_a_at

11750887_a_at

11757937_s_at

16730540

202076_at

329

3346585

3346586

3346587

3346588

3346589

3346590

3346593

3346594

3346595

3346596

3346597

3346598

3346599

3346601

3346604

3346605

3346607

3346608

3346609

3346610

3346611

3346612

3346613

3346614

3346615

3346616

36578_at

7943424

A_14_P124015

A_14_P129741

A_14_P131109

A_24_P115774

GE59117

GO:0000003

GO:0000209

GO:0001666

GO:0001741

GO:0001890

GO:0002376

GO:0002756

GO:0003674

GO:0003713

GO:0004842

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005694

GO:0005737

GO:0005829

GO:0005886

GO:0006464

GO:0006915

GO:0006950

GO:0007049

GO:0007165

GO:0007166

GO:0007249

GO:0008150

GO:0008219

GO:0008270

GO:0008283

GO:0009056

GO:0009058

GO:0009898

GO:0010243

GO:0010803

GO:0014070

GO:0016579

GO:0016740

GO:0022607

GO:0030154

GO:0030234

GO:0031398

GO:0032182

GO:0032991

GO:0033209

GO:0034121

GO:0034641

GO:0035631

GO:0035666

GO:0038061

GO:0039535

GO:0042127

GO:0042802

GO:0042981

GO:0043027

GO:0043066

GO:0043123

GO:0043130

GO:0043154

GO:0043161

GO:0043167

GO:0043226

GO:0044877

GO:0045088

GO:0045121

GO:0045471

GO:0045595

GO:0046872

GO:0047485

GO:0048856

GO:0050727

GO:0051087

GO:0051591

GO:0051604

GO:0051726

GO:0060544

GO:0060546

GO:0061630

GO:0065003

GO:0070266

GO:0070424

GO:0071356

GO:0098770

GO:1901222

GO:1902443

GO:1902523

GO:1902524

GO:1902527

GO:1902916

GO:1903508

GO:1990001

GO:2000116

GO:2000377

ILMN_1768194

ILMN_2182704

PH_hs_0015035

TC11000957.hg

U37547_at

g10880127_3p_at

Participant Of

output

Caspase mediated cleavage of C-IAP1

Other forms of this molecule

K63polyUb-BIRC2 [cytosol]

K48pUb-BIRC2 [cytosol]

BIRC2(373-618) [cytosol]

BIRC2 [cytosol]

Inferred To

Diap2 [cytosol] (Drosophila melanogaster)

birc2 [cytosol] (Danio rerio)

birc2 [cytosol] (Xenopus tropicalis)

bir1 [cytosol] (Schizosaccharomyces pombe)

BIRC2 [cytosol] (Canis familiaris)

BIRC2(1-372) [cytosol] (Gallus gallus)

Birc2 [cytosol] (Mus musculus)

Birc2 [cytosol] (Rattus norvegicus)

Cross References

ZINC - Investigational

BIRC2_HUMAN

RefSeq

NP_001243095.1, NP_001157.1, NP_001243092.1

OpenTargets

ENSG00000110330

IntEnz

2.3.2.27

HPA

ENSG00000110330-BIRC2

GeneCards

Q13490

ZINC - Substances

BIRC2_HUMAN

ZINC target

Q13490

Ensembl

ENSG00000110330, ENST00000530675, ENSP00000227758, ENST00000227758, ENST00000613397, ENSP00000477613, ENSP00000431723

PRO

Q13490

ZINC - Predictions - Purchasable

BIRC2_HUMAN

PDB

3T6P, 6HPR, 4EB9, 4LGE, 4KMN, 3M1D, 4LGU, 3D9U, 4HY5, 1QBH, 5M6N, 3MUP, 3OZ1, 4MU7, 2L9M, 3D9T, 3UW4, 4HY4, 6EXW, 4MTI

Interactors (49)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.95	17
UniProt:P55211 CASP9	6	CASP9(1-416) [cytosol] (R-HSA-57033) p-T125-CASP9(1-416) [cytosol] (R-HSA-9627087) CASP9(331-416) [cytosol] (R-HSA-141639) CASP9(?-315) [cytosol] (R-HSA-141638) CASP9(1-416) [cytosol] (R-HSA-114257) p-S196-CASP9(1-416) [cytosol] (R-HSA-198636)	0.92	12
UniProt:P01375 TNF	5	TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(52-76) [extracellular region] (R-HSA-8863375) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-233) [plasma membrane] (R-HSA-66220)	0.788	5
UniProt:Q9Y3E2 BOLA1			0.781	7
UniProt:Q9NR28 DIABLO	2	DIABLO [mitochondrial intermembrane space] (R-HSA-64637) DIABLO [cytosol] (R-HSA-114298)	0.775	6
UniProt:Q96HA8 NTAQ1			0.743	6
UniProt:Q96CA5 BIRC7			0.743	6
UniProt:Q13077 TRAF1	3	TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1 [cytosol] (R-HSA-5634163) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.738	5
UniProt:Q96CN9 GCC1	1	GCC1 [cytosol] (R-HSA-6813877)	0.718	6
UniProt:P08949-2 NMB			0.718	6
UniProt:Q8N3J5 PPM1K	1	PPM1K [mitochondrial matrix] (R-HSA-5693145)	0.718	6
UniProt:Q9NQT4 EXOSC5	2	EXOSC5 [nucleoplasm] (R-HSA-6791550) EXOSC5 [cytosol] (R-HSA-429889)	0.718	6
UniProt:Q13546 RIPK1	14	PolyUb-RIPK1 [cytosol] (R-HSA-6783197) K48polyUb-RIPK1 [cytosol] (R-HSA-6783308) RIPK1 D324N [cytosol] (R-HSA-9693930) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 [plasma membrane] (R-HSA-937073) K63pUb-K377-RIP1 [cytosol] (R-HSA-5212672) RIPK1(1-324) [cytosol] (R-HSA-5212664) RIPK1(325-671) [cytosol] (R-HSA-5212671) p-S166-RIPK1 [cytosol] (R-HSA-5218872) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) RIPK1 [endosome membrane] (R-HSA-450326) RIPK1 [cytosol] (R-HSA-168651)	0.697	5
UniProt:P19438 TNFRSF1A	3	TNFRSF1A [plasma membrane] (R-HSA-5675738) TNFRSF1A(41-201) [extracellular region] (R-HSA-6785048) TNFRSF1A(22-455) [plasma membrane] (R-HSA-66344)	0.69	4
UniProt:Q13490 BIRC2	5	K48pUb-BIRC2 [cytosol] (R-HSA-5675479) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(1-372) [cytosol] (R-HSA-202913) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2 [cytosol] (R-HSA-50847)	0.667	4
UniProt:Q9BZW7 TSG10			0.666	4
UniProt:Q92844 TANK	2	TANK [cytosol] (R-HSA-933407) K63polyUb-TANK [cytosol] (R-HSA-5362480)	0.643	4
ChEBI:47924 N,N'-(HEXANE-1,6-DIYL)BIS(1-{(2S)-2-CYCLOHEXYL-2-[(N-METHYL-L-ALANYL)AMINO]ACETYL}-L-PROLYL-BETA-PHENYL-L-PHENYLALANINAMIDE)			0.618	4
ChEBI:47922 METHYL 1-{(2S)-2-CYCLOHEXYL-2-[(N-METHYL-L-ALANYL)AMINO]ACETYL}-L-PROLYL-BETA-PHENYL-L-PHENYLALANINATE			0.618	6
UniProt:P57078 RIPK4			0.602	3
UniProt:Q9Y572 RIPK3	7	p-S199,227-RIPK3 [cytosol] (R-HSA-5218873) RIPK3 [cytosol] (R-HSA-450328) Ub-K55,363-RIPK3 [cytosol] (R-HSA-9688825) RIPK3(1-328) [cytosol] (R-HSA-9686917) RIPK3(329-518) [cytosol] (R-HSA-9686937) OGlcNAc-T467-RIPK3 [cytosol] (R-HSA-9687819) p-S199,227, K48pUb-363-RIPK3 [cytosol] (R-HSA-9686933)	0.602	3
UniProt:O43353 RIPK2	2	Ub-209-RIPK2 [cytosol] (R-HSA-706483) RIPK2 [cytosol] (R-HSA-168402)	0.602	3
UniProt:P14136 GFAP	3	GFAP [lysosomal membrane] (R-HSA-9625195) p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:P40325 HUA1			0.556	3
UniProt:A0A087WZT3 A0A087WZT3			0.556	3
UniProt:P32502	1	GCD7 [cytosol] (R-SCE-72519)	0.556	3
UniProt:P08949 NMB	1	NMB(47-56) [extracellular region] (R-HSA-375361)	0.556	3
UniProt:Q06455-2 RUNX1T1			0.556	3
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q01976	1	YSA1 [cytosol] (R-SCE-2393933)	0.556	3
UniProt:P38339 RGD1			0.556	3
UniProt:Q3E793 BOL1			0.556	3
UniProt:P40937 RFC5	1	RFC5 [nucleoplasm] (R-HSA-68427)	0.556	3
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q9Y4C2-2 TCAF1			0.556	3
UniProt:Q96CJ1 EAF2	1	EAF2 [nucleoplasm] (R-HSA-8932790)	0.556	3
UniProt:Q9UBU9 NXF1	2	NXF1 [nucleoplasm] (R-HSA-111690) NXF1 [cytosol] (R-HSA-156481)	0.556	3
UniProt:P51451 BLK	2	BLK [cytosol] (R-HSA-983580) MyrG2-BLK [plasma membrane] (R-HSA-9606871)	0.556	3
UniProt:P51813 BMX	3	BMX(243-675) [cytosol] (R-HSA-351875) BMX [cytosol] (R-HSA-351917) BMX(1-242) [cytosol] (R-HSA-351899)	0.556	3
UniProt:Q96EP0 RNF31	1	RNF31 [cytosol] (R-HSA-5212660)	0.527	3
UniProt:Q13114 TRAF3	5	K48polyUb-TRAF3 [cytosol] (R-HSA-5668444) TRAF3 R118W [cytosol] (R-HSA-5602321) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 [cytosol] (R-HSA-914241) K63polyUb-TRAF3 [cytosol] (R-HSA-936402)	0.527	3
UniProt:Q14790 CASP8	8	CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(1-479) [cytosol] (R-HSA-57031) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(217-374) [cytosol] (R-HSA-75975)	0.527	2
UniProt:Q9Y6K9 IKBKG	12	IKBKG [nucleoplasm] (R-HSA-4755413) SUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wro447 [cytosol] (R-HSA-5262978) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-NEMO [cytosol] (R-HSA-202530) IKBKG [cytosol] (R-HSA-168108)	0.527	3
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.525	2
UniProt:P55210 CASP7	5	CASP7(207-303) [nucleoplasm] (R-HSA-351924) CASP7(24-198) [nucleoplasm] (R-HSA-351927) CASP7(2-303) [cytosol] (R-HSA-57029) CASP7(24-198) [cytosol] (R-HSA-141641) CASP7(207-303) [cytosol] (R-HSA-141642)	0.524	2
UniProt:Q96FW1 OTUB1	2	OTUB1 [nucleoplasm] (R-HSA-6783242) OTUB1 [cytosol] (R-HSA-933411)	0.499	3
UniProt:Q9NP84 TNFRSF12A	1	TNFRSF12A [plasma membrane] (R-HSA-5675666)	0.499	2

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