Caspase-mediated cleavage of E-Cadherin

Stable Identifier
R-HSA-202939
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Caspase-mediated cleavage of E-Cadherin
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The cleavage of E-cadherin at both the intracellular and extracellular domains likely contributes to the disruption of cadherin-mediated cell-cell contacts in apoptotic cells. Loss of cell contact is necessary for cell rounding and exit from the epithelium (Steinhusen et al., 2001).
Literature References
PubMed ID Title Journal Year
11076937 Cleavage and shedding of E-cadherin after induction of apoptosis

Steinhusen, U, Weiske, J, Badock, V, Tauber, R, Bommert, K, Huber, O

J. Biol. Chem. 2001
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Output
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as an event of
Catalyst Activity

cysteine-type endopeptidase activity of Caspase-3 [cytosol]

Physical Entity
Caspase-3 [cytosol] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
Caspase-mediated cleavage of E-Cadherin (Bos taurus)
Caspase-mediated cleavage of E-Cadherin (Canis familiaris)
Caspase-mediated cleavage of E-Cadherin (Danio rerio)
Caspase-mediated cleavage of E-Cadherin (Drosophila melanogaster)
Caspase-mediated cleavage of E-Cadherin (Gallus gallus)
Caspase-mediated cleavage of E-Cadherin (Mus musculus)
Caspase-mediated cleavage of E-Cadherin (Rattus norvegicus)
Caspase-mediated cleavage of E-Cadherin (Sus scrofa)
Authored
Schulze-Osthoff, K  (2007-09-03)
Reviewed
Ranganathan, S  (2008-06-11)
Created
Matthews, L  (2007-11-12)
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