Caspase-mediated cleavage of E-Cadherin

Stable Identifier
R-HSA-202939
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The cleavage of E-cadherin at both the intracellular and extracellular domains likely contributes to the disruption of cadherin-mediated cell-cell contacts in apoptotic cells. Loss of cell contact is necessary for cell rounding and exit from the epithelium (Steinhusen et al., 2001).

Literature References
PubMed ID Title Journal Year
11076937 Cleavage and shedding of E-cadherin after induction of apoptosis

Steinhusen, U, Weiske, J, Badock, V, Tauber, R, Bommert, K, Huber, O

J. Biol. Chem. 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of Caspase-3 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created