Autophosphorylation of PAK1

Stable Identifier
R-HSA-2029454
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PAK1 needs autophosphorylation for complete activation. PAK1 is autophosphorylated at several sites, but S144 flanking the kinase inhibitor region and T423 within the catalytic domain are the two conserved sites that regulate the catalytic activity (Chong et al. 2001, Parrini et al. 2001).

Literature References
PubMed ID Title Journal Year
11278486 The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

Chong, C, Tan, L, Lim, L, Manser, E

J Biol Chem 2001
11804587 Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1

Parrini, MC, Lei, M, Harrison, SC, Mayer, BJ

Mol Cell 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of PAK1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
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