PAK1 phosphorylates LIMK1

Stable Identifier
R-HSA-2029460
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

LIM kinases are serine protein kinases with a unique combination of two N-terminal LIM motifs, a central PDZ domain, and a C-terminal protein kinase domain. LIMK1 is one of the downstream targets of PAK1 and is activated through phosphorylation by PAK1 on T508 within its activation loop (Edwards et al. 1999, Aizawa et al. 2001). LIM-kinase is responsible for the tight regulation of the activity of cofilin (a protein that depolymerizes actin filaments) and thus maintains the balance between actin assembly and disassembly. Phosphorylated cofilin is inactive, resulting in stabilization of the actin cytoskeleton.

Literature References
PubMed ID Title Journal Year
10559936 Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

Edwards, DC, Sanders, LC, Bokoch, GM, Gill, GN

Nat Cell Biol 1999
11276226 Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse

Aizawa, H, Wakatsuki, S, Ishii, A, Moriyama, K, Sasaki, Y, Ohashi, K, Sekine-Aizawa, Y, Sehara-Fujisawa, A, Mizuno, K, Goshima, Y, Yahara, I

Nat Neurosci 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S144,T423-PAK1 [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed