Branching and elongation of mother and daughter filaments

Stable Identifier
R-HSA-2029473
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
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Summation

ATP bound G-actin monomers are added to the fast growing barbed ends of both mother and daughter filaments. The polymerization of these filaments drives membrane protrusion. In the process of phagocytosis, pseudopodia extend around the antibody-bound particle to form the phagocytic cup. This elongation continues until the filament reaches steady state equilibrium with free G-actin monomers (Millard et al. 2004, Le Clainche et al. 2008).

Literature References
PubMed ID Title Journal Year
15040784 Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex

Millard, TH, Sharp, SJ, Machesky, LM

Biochem J 2004
18391171 Regulation of actin assembly associated with protrusion and adhesion in cell migration

Le Clainche, C, Carlier, MF

Physiol Rev 2008
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Orthologous Events
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