FCGR activation

Stable Identifier
R-HSA-2029481
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cross-linking of FCGRs with IgG coated immune complexes results in tyrosine phosphorylation of the immuno tyrosine activation motif (ITAMs) of the rececptor by membrane-bound tyrosine kinases of the SRC family. The phosphorylated ITAM tyrosines serve as docking sites for Src homology 2 (SH2) domain-containing SYK kinase. Recruitment and activation of SYK is critical for FCGR-mediated signaling in phagocytosis, but the exact role of SYK in this process is unclear. Activated SYK then transmits downstream signals leading to actin polymerization and particle internalization.

Literature References
PubMed ID Title Journal Year
17050193 Fcgamma receptor signaling in phagocytes

Joshi, T, Butchar, JP, Tridandapani, S

Int J Hematol 2006
12488490 Signal transduction during Fc receptor-mediated phagocytosis

García-García, E, Rosales, C

J Leukoc Biol 2002
18322649 Molecular mechanisms of phagocytic uptake in mammalian cells

Groves, E, Dart, AE, Covarelli, V, Caron, E

Cell Mol Life Sci 2008
Participants
Participant Of
Orthologous Events
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Reviewed