Regulation of actin dynamics for phagocytic cup formation

Stable Identifier
R-HSA-2029482
Type
Pathway
Species
Homo sapiens
Compartment
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Summation

The actin cytoskeleton is fundamental for phagocytosis and members of the Rho family GTPases RAC and CDC42 are involved in actin cytoskeletal regulation leading to pseudopod extension. Active RAC and CDC42 exert their action through the members of WASP family proteins (WASP/N-WASP/WAVE) and ARP2/3 complex. Actin filaments move from the bottom toward the top of the phagocytic cup during pseudopod extension.

Literature References
PubMed ID Title Journal Year
17477841 Regulation of actin filament assembly by Arp2/3 complex and formins Annu Rev Biophys Biomol Struct 2007
15452139 Regulation of WASP/WAVE proteins: making a long story short J Cell Biol 2004
15981459 Regulation of phagocytosis by Rho GTPases Curr Top Microbiol Immunol 2005
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