Reactome | WASL [plasma membrane]

WASL [plasma membrane]

Stable Identifier

R-HSA-203010

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

N-WASP

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Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Axon guidance (Homo sapiens)
  - Netrin-1 signaling (Homo sapiens)
    - DCC mediated attractive signaling (Homo sapiens)
      - Recruitment and activation of N-WASP by Cdc42 (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Homo sapiens)
        
        WASL [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00401 WASL

Gene Names

WASL

Chain

initiator methionine:1, chain:2-505

Reference Genes

BioGPS Gene:8976 WASL

COSMIC (genes):WASL WASL

CTD Gene:8976 WASL

dbSNP Gene:8976 WASL

ENSEMBL:ENSG00000106299 WASL

HGNC:12735 WASL

KEGG Gene (Homo sapiens):8976 WASL

Monarch:8976 WASL

NCBI Gene:8976 WASL

OMIM:605056 WASL

UCSC:O00401 WASL

Reference Transcript

RefSeq:NM_003941.3 WASL

Other Identifiers

0006040026

11717284_a_at

11717285_a_at

11754385_s_at

17062460

205809_s_at

205810_s_at

224813_at

2FF3

2LNH

2VCP

3070714

3070715

3070716

3070717

3070721

3070722

3070727

3070728

3070729

3070730

3070731

3070732

3070735

3070736

3070737

3070750

3070751

3070752

3070753

3070754

3070755

3070756

321_at

39875_at

44736_at

4CC2

4CC7

5399

5750

8142671

8976

A_33_P3405444

AAH52955

AAQ96857

AC006333

AM295156

BAA20128

BC052955

CAB005399

CAL26602

CCDS34743

D88460

D88460_at

ENSG00000106299

ENSP00000223023

ENST00000223023

ENST00000223023.4

EntrezGene:8976

EntrezGene:WASL

g4505322_3p_a_at

GE57430

GO:0000147

GO:0000902

GO:0002376

GO:0003674

GO:0003779

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0006810

GO:0006897

GO:0006900

GO:0007009

GO:0007010

GO:0007015

GO:0007049

GO:0007165

GO:0008092

GO:0008150

GO:0008154

GO:0009058

GO:0009617

GO:0015629

GO:0016050

GO:0016192

GO:0022607

GO:0030027

GO:0030036

GO:0030041

GO:0030048

GO:0030050

GO:0030154

GO:0030234

GO:0030478

GO:0030479

GO:0030666

GO:0030695

GO:0030705

GO:0031410

GO:0032880

GO:0034629

GO:0034641

GO:0038096

GO:0040011

GO:0043226

GO:0045944

GO:0048013

GO:0048856

GO:0048870

GO:0050999

GO:0051015

GO:0051301

GO:0051491

GO:0051653

GO:0051666

GO:0060997

GO:0061024

GO:0065003

GO:0070062

GO:1903526

GO:2000370

GO:2000402

GO:2000601

HGNC:12735

HPA005750

Hs.170065.0.S1_3p_at

Hs.288830.0.A1_3p_a_at

ILMN_1666004

IPR000095

IPR000697

IPR003124

IPR011026

IPR011993

IPR030214

IPR033927

IPR036936

MIM:605056

NM_003941

NP_003932

PF00568

PF00786

PF02205

SM00246

SM00285

SM00461

TC07001823.hg

UPI000013C821

WASL

WASL-201

Participant Of

hasComponent

Other forms of this molecule

p-Y256-WASL [cytosol]

N-WASP [cytosol]

WASL [endocytic vesicle membrane]

Inferred To

Homologues of WASL [plasma membrane] (Dictyostelium discoideum)

WASL [plasma membrane] (Bos taurus)

WASL [plasma membrane] (Caenorhabditis elegans)

WASL [plasma membrane] (Canis familiaris)

WASL [plasma membrane] (Danio rerio)

WASL [plasma membrane] (Dictyostelium discoideum)

WASL [plasma membrane] (Drosophila melanogaster)

WASL [plasma membrane] (Mus musculus)

WASL [plasma membrane] (Rattus norvegicus)

WASL [plasma membrane] (Saccharomyces cerevisiae)

WASL [plasma membrane] (Schizosaccharomyces pombe)

WASL [plasma membrane] (Sus scrofa)

WASL [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_003932.3

OpenTargets

ENSG00000106299

GeneCards

O00401

PRO

O00401

PDB

4CC2, 2VCP, 2LNH, 4CC7, 2FF3

Interactors (40)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.899	9
UniProt:O43516 WIPF1	1	WIPF1 [cytosol] (R-HSA-201874)	0.851	8
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.782	7
UniProt:O76064 RNF8	1	RNF8 [nucleoplasm] (R-HSA-5682539)	0.764	6
UniProt:P60953 CDC42	3	CDC42 [plasma membrane] (R-HSA-449545) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [cytosol] (R-HSA-442630)	0.75	4
UniProt:Q8TF74 WIPF2	1	WIPF2 [cytosol] (R-HSA-2197666)	0.712	4
UniProt:Q15811 ITSN1	1	ITSN1 [cytosol] (R-HSA-3006481)	0.704	5
UniProt:P61157 ACTR3	1	ARP3 [cytosol] (R-BTA-419940)	0.702	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.696	5
UniProt:O15145 ARPC3	1	ARPC3 [cytosol] (R-HSA-200812)	0.696	5
UniProt:Q9H4E5 RHOJ	2	RHOJ [plasma membrane] (R-HSA-3006725) RHOJ [cytosol] (R-HSA-3006722)	0.696	5
UniProt:Q99828 CIB1			0.633	7
UniProt:P0DJ88 ESFU2			0.623	2
UniProt:P68135 ACTS			0.609	2
UniProt:O15143 ARPC1B	1	ARPC1B [cytosol] (R-HSA-6787770)	0.609	2
UniProt:O60504-2 SORBS3			0.589	3
UniProt:P16333 NCK1	2	NCK1 [cytosol] (R-HSA-197954) NCK1 [plasma membrane] (R-HSA-202992)	0.564	2
UniProt:Q6XZF7-1 DNMBP			0.558	2
UniProt:E7ERP6 E7ERP6			0.556	3
IntAct:EBI-16429374 CCSB ISOFORM ID			0.556	3
UniProt:A0A0S2Z4D7 A0A0S2Z4D7			0.556	3
UniProt:Q13882 PTK6	5	PTK6 [cytosol] (R-HSA-8848000) p-Y342-PTK6 [cytosol] (R-HSA-8848007) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103) p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) p-Y351-PTK6 [cytosol] (R-HSA-8857570)	0.556	3
UniProt:A6NGB9 WIPF3	1	WIPF3 [cytosol] (R-HSA-2197670)	0.547	2
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.547	2
UniProt:Q9ESJ4	1	NCKIPSD [cytosol] (R-MMU-2197671)	0.544	2
UniProt:Q8R511	1	FNBP1 [cytosol] (R-RNO-8862261)	0.524	2
UniProt:Q9Y5X1 SNX9	3	SNX9 [Golgi membrane] (R-HSA-432988) SNX9 [cytosol] (R-HSA-8867737) SNX9 [cytoplasmic vesicle membrane] (R-HSA-432990)	0.524	2
UniProt:P16333-1 NCK1			0.499	2
UniProt:P59998 ARPC4	1	ARPC4 [cytosol] (R-HSA-200813)	0.488	2
UniProt:Q15642-2 TRIP10			0.488	2
UniProt:O94875-10 SORBS2			0.488	2
IntAct:EBI-12002588 OSTF1			0.488	2
UniProt:P57075-2 UBASH3A			0.488	2
UniProt:Q8IWW6-4 ARHGAP12			0.488	2
UniProt:Q9UNF0 PACSIN2	1	PACSIN2 [cytosol] (R-HSA-8868267)	0.488	2
IntAct:EBI-11958528 SH3RF1			0.488	2
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.488	2
UniProt:Q8TF42 UBS3B			0.488	2
UniProt:Q9NYB9-2 ABI2			0.488	2
UniProt:Q9UKS6 PACSIN3	1	PACSIN3 [cytosol] (R-HSA-8868270)	0.488	2