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WASL [plasma membrane]
Stable Identifier
R-HSA-203010
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
N-WASP
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Netrin-1 signaling (Homo sapiens)
DCC mediated attractive signaling (Homo sapiens)
Recruitment and activation of N-WASP by Cdc42 (Homo sapiens)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Homo sapiens)
WASL [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of nitric oxide: NOS3 activation and regulation (Homo sapiens)
NOSTRIN mediated eNOS trafficking (Homo sapiens)
NOSTRIN mediated translocation of eNOS from plasma membrane (Homo sapiens)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Homo sapiens)
WASL [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Homo sapiens)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Homo sapiens)
WASL [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00401 WASL
Gene Names
WASL
Chain
initiator methionine:1, chain:2-505
Reference Genes
BioGPS Gene:8976 WASL
COSMIC (genes):WASL WASL
CTD Gene:8976 WASL
dbSNP Gene:8976 WASL
ENSEMBL:ENSG00000106299 WASL
HGNC:12735 WASL
KEGG Gene (Homo sapiens):8976 WASL
Monarch:8976 WASL
NCBI Gene:8976 WASL
OMIM:605056 WASL
UCSC:O00401 WASL
Reference Transcript
RefSeq:NM_003941.3 WASL
Other Identifiers
0006040026
11717284_a_at
11717285_a_at
11754385_s_at
17062460
205809_s_at
205810_s_at
224813_at
3070714
3070715
3070716
3070717
3070721
3070722
3070727
3070728
3070729
3070730
3070731
3070732
3070735
3070736
3070737
3070750
3070751
3070752
3070753
3070754
3070755
3070756
321_at
39875_at
44736_at
8142671
8976
A_33_P3405444
D88460_at
GE57430
GO:0000902
GO:0002376
GO:0003674
GO:0003779
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0005884
GO:0005886
GO:0006810
GO:0006900
GO:0007009
GO:0007010
GO:0007015
GO:0007049
GO:0007165
GO:0008092
GO:0008150
GO:0008154
GO:0009058
GO:0009617
GO:0015629
GO:0016050
GO:0016192
GO:0022607
GO:0030027
GO:0030036
GO:0030041
GO:0030048
GO:0030050
GO:0030154
GO:0030234
GO:0030478
GO:0030666
GO:0030695
GO:0030705
GO:0031410
GO:0032880
GO:0034330
GO:0034629
GO:0034641
GO:0038096
GO:0040011
GO:0043226
GO:0045944
GO:0048013
GO:0048856
GO:0048870
GO:0050999
GO:0051301
GO:0051491
GO:0051653
GO:0060997
GO:0061024
GO:0065003
GO:0070062
GO:1903526
GO:2000370
GO:2000402
GO:2000601
Hs.170065.0.S1_3p_at
Hs.288830.0.A1_3p_a_at
ILMN_1666004
TC07001823.hg
g4505322_3p_a_at
Participant Of
hasComponent
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane]
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane]
Other forms of this molecule
p-Y256-WASL [cytosol]
N-WASP [cytosol]
WASL [endocytic vesicle membrane]
Inferred To
Wasl [plasma membrane] (Mus musculus)
Wasl [plasma membrane] (Rattus norvegicus)
wasla [plasma membrane] (Danio rerio)
wasl [plasma membrane] (Xenopus tropicalis)
WASL [plasma membrane] (Canis familiaris)
WASL [plasma membrane] (Gallus gallus)
WASL [plasma membrane] (Sus scrofa)
Cross References
RefSeq
NP_003932.3
OpenTargets
ENSG00000106299
GeneCards
O00401
HPA
ENSG00000106299-WASL
Ensembl
ENST00000223023
,
ENSP00000223023
,
ENSG00000106299
PRO
O00401
PDB
2LNH
,
4CC2
,
2VCP
,
4CC7
,
2FF3
Interactors (41)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.928
11
UniProt:O43516 WIPF1
1
WIPF1 [cytosol]
(R-HSA-201874)
0.851
8
UniProt:O76064 RNF8
1
RNF8 [nucleoplasm]
(R-HSA-5682539)
0.83
8
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.782
7
UniProt:P60953 CDC42
3
CDC42 [cytosol]
(R-HSA-442630)
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
CDC42 [plasma membrane]
(R-HSA-449545)
0.75
4
UniProt:Q8TF74 WIPF2
1
WIPF2 [cytosol]
(R-HSA-2197666)
0.743
5
UniProt:O00560 SDCBP
3
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [cytosol]
(R-HSA-373639)
0.718
6
UniProt:O15145 ARPC3
1
ARPC3 [cytosol]
(R-HSA-200812)
0.718
6
UniProt:Q9H4E5 RHOJ
2
RHOJ [plasma membrane]
(R-HSA-3006725)
RHOJ [cytosol]
(R-HSA-3006722)
0.718
6
UniProt:Q15811 ITSN1
1
ITSN1 [cytosol]
(R-HSA-3006481)
0.704
5
UniProt:P61157 ACTR3
1
ARP3 [cytosol]
(R-BTA-419940)
0.702
3
UniProt:Q8X482 ESPFU
0.691
5
UniProt:Q99828 CIB1
0.633
7
UniProt:P0DJ88 ESFU2
0.623
2
UniProt:O15143 ARPC1B
1
ARPC1B [cytosol]
(R-HSA-6787770)
0.609
2
UniProt:P68135 ACTS
0.609
2
UniProt:O60504-2 SORBS3
0.589
3
UniProt:P16333 NCK1
2
NCK1 [cytosol]
(R-HSA-197954)
NCK1 [plasma membrane]
(R-HSA-202992)
0.564
2
UniProt:Q6XZF7-1 DNMBP
0.558
2
UniProt:P59998 ARPC4
1
ARPC4 [cytosol]
(R-HSA-200813)
0.556
3
UniProt:O94875-10 SORBS2
0.556
3
UniProt:Q15642-2 TRIP10
0.556
5
UniProt:P57075-2 UBASH3A
0.556
3
UniProt:Q8IWW6-4 ARHGAP12
0.556
3
IntAct:EBI-22315148 CCSB ORF ID
0.556
3
UniProt:E7ERP6 E7ERP6
0.556
3
UniProt:Q9UNF0 PACSIN2
1
PACSIN2 [cytosol]
(R-HSA-8868267)
0.556
3
IntAct:EBI-22313194 CCSB ORF ID
0.556
3
IntAct:EBI-16429374 CCSB ISOFORM ID
0.556
3
UniProt:Q8TF42 UBS3B
0.556
3
UniProt:Q13882 PTK6
5
p-Y342-PTK6 [cytosol]
(R-HSA-8848007)
p-Y342-PTK6 [nucleoplasm]
(R-HSA-8848937)
PTK6 [cytosol]
(R-HSA-8848000)
p-Y351-PTK6 [cytosol]
(R-HSA-8857570)
p-Y342,Y447-PTK6 [cytosol]
(R-HSA-8849103)
0.556
3
UniProt:A0A0S2Z4D7 A0A0S2Z4D7
0.556
3
UniProt:Q9NYB9-2 ABI2
0.556
5
UniProt:Q9UKS6 PACSIN3
1
PACSIN3 [cytosol]
(R-HSA-8868270)
0.556
3
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.553
2
UniProt:A6NGB9 WIPF3
1
WIPF3 [cytosol]
(R-HSA-2197670)
0.547
2
UniProt:Q9UQB8 BAIAP2
1
BAIAP2 [cytosol]
(R-HSA-442574)
0.547
2
UniProt:Q9ESJ4
1
Nckipsd [cytosol]
(R-MMU-2197671)
0.544
2
UniProt:Q8R511
1
Fnbp1 [cytosol]
(R-RNO-8862261)
0.524
2
UniProt:Q9Y5X1 SNX9
3
SNX9 [Golgi membrane]
(R-HSA-432988)
SNX9 [cytosol]
(R-HSA-8867737)
SNX9 [cytoplasmic vesicle membrane]
(R-HSA-432990)
0.524
2
UniProt:P16333-1 NCK1
0.499
2
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