Reactome | WASL [plasma membrane]

WASL [plasma membrane]

Stable Identifier

R-HSA-203010

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

N-WASP

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Netrin-1 signaling (Homo sapiens)
      - DCC mediated attractive signaling (Homo sapiens)
        
        Recruitment and activation of N-WASP by Cdc42 (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Homo sapiens)
        
        WASL [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00401 WASL

Gene Names

WASL

Chain

initiator methionine:1, chain:2-505

Reference Genes

BioGPS Gene:8976 WASL

COSMIC (genes):WASL WASL

CTD Gene:8976 WASL

dbSNP Gene:8976 WASL

ENSEMBL:ENSG00000106299 WASL

HGNC:12735 WASL

KEGG Gene (Homo sapiens):8976 WASL

Monarch:8976 WASL

NCBI Gene:8976 WASL

OMIM:605056 WASL

UCSC:O00401 WASL

Reference Transcript

RefSeq:NM_003941.3 WASL

Other Identifiers

0006040026

11717284_a_at

11717285_a_at

11754385_s_at

17062460

205809_s_at

205810_s_at

224813_at

3070714

3070715

3070716

3070717

3070721

3070722

3070727

3070728

3070729

3070730

3070731

3070732

3070735

3070736

3070737

3070750

3070751

3070752

3070753

3070754

3070755

3070756

321_at

39875_at

44736_at

8142671

8976

A_33_P3405444

D88460_at

GE57430

GO:0000902

GO:0002376

GO:0003674

GO:0003779

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0006810

GO:0006900

GO:0007009

GO:0007010

GO:0007015

GO:0007049

GO:0007165

GO:0008092

GO:0008150

GO:0008154

GO:0009058

GO:0009617

GO:0015629

GO:0016050

GO:0016192

GO:0022607

GO:0030027

GO:0030036

GO:0030041

GO:0030048

GO:0030050

GO:0030154

GO:0030234

GO:0030478

GO:0030666

GO:0030695

GO:0030705

GO:0031410

GO:0032880

GO:0034330

GO:0034629

GO:0034641

GO:0038096

GO:0040011

GO:0043226

GO:0045944

GO:0048013

GO:0048856

GO:0048870

GO:0050999

GO:0051301

GO:0051491

GO:0051653

GO:0060997

GO:0061024

GO:0065003

GO:0070062

GO:1903526

GO:2000370

GO:2000402

GO:2000601

Hs.170065.0.S1_3p_at

Hs.288830.0.A1_3p_a_at

ILMN_1666004

TC07001823.hg

g4505322_3p_a_at

Participant Of

hasComponent

Other forms of this molecule

p-Y256-WASL [cytosol]

N-WASP [cytosol]

WASL [endocytic vesicle membrane]

Inferred To

Wasl [plasma membrane] (Mus musculus)

Wasl [plasma membrane] (Rattus norvegicus)

wasla [plasma membrane] (Danio rerio)

wasl [plasma membrane] (Xenopus tropicalis)

WASL [plasma membrane] (Canis familiaris)

WASL [plasma membrane] (Gallus gallus)

WASL [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_003932.3

OpenTargets

ENSG00000106299

GeneCards

O00401

HPA

ENSG00000106299-WASL

Ensembl

ENST00000223023, ENSP00000223023, ENSG00000106299

PRO

O00401

PDB

2LNH, 4CC2, 2VCP, 4CC7, 2FF3

Interactors (41)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.928	11
UniProt:O43516 WIPF1	1	WIPF1 [cytosol] (R-HSA-201874)	0.851	8
UniProt:O76064 RNF8	1	RNF8 [nucleoplasm] (R-HSA-5682539)	0.83	8
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.782	7
UniProt:P60953 CDC42	3	CDC42 [cytosol] (R-HSA-442630) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [plasma membrane] (R-HSA-449545)	0.75	4
UniProt:Q8TF74 WIPF2	1	WIPF2 [cytosol] (R-HSA-2197666)	0.743	5
UniProt:O00560 SDCBP	3	SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206) SDCBP [cytosol] (R-HSA-373639)	0.718	6
UniProt:O15145 ARPC3	1	ARPC3 [cytosol] (R-HSA-200812)	0.718	6
UniProt:Q9H4E5 RHOJ	2	RHOJ [plasma membrane] (R-HSA-3006725) RHOJ [cytosol] (R-HSA-3006722)	0.718	6
UniProt:Q15811 ITSN1	1	ITSN1 [cytosol] (R-HSA-3006481)	0.704	5
UniProt:P61157 ACTR3	1	ARP3 [cytosol] (R-BTA-419940)	0.702	3
UniProt:Q8X482 ESPFU			0.691	5
UniProt:Q99828 CIB1			0.633	7
UniProt:P0DJ88 ESFU2			0.623	2
UniProt:O15143 ARPC1B	1	ARPC1B [cytosol] (R-HSA-6787770)	0.609	2
UniProt:P68135 ACTS			0.609	2
UniProt:O60504-2 SORBS3			0.589	3
UniProt:P16333 NCK1	2	NCK1 [cytosol] (R-HSA-197954) NCK1 [plasma membrane] (R-HSA-202992)	0.564	2
UniProt:Q6XZF7-1 DNMBP			0.558	2
UniProt:P59998 ARPC4	1	ARPC4 [cytosol] (R-HSA-200813)	0.556	3
UniProt:O94875-10 SORBS2			0.556	3
UniProt:Q15642-2 TRIP10			0.556	5
UniProt:P57075-2 UBASH3A			0.556	3
UniProt:Q8IWW6-4 ARHGAP12			0.556	3
IntAct:EBI-22315148 CCSB ORF ID			0.556	3
UniProt:E7ERP6 E7ERP6			0.556	3
UniProt:Q9UNF0 PACSIN2	1	PACSIN2 [cytosol] (R-HSA-8868267)	0.556	3
IntAct:EBI-22313194 CCSB ORF ID			0.556	3
IntAct:EBI-16429374 CCSB ISOFORM ID			0.556	3
UniProt:Q8TF42 UBS3B			0.556	3
UniProt:Q13882 PTK6	5	p-Y342-PTK6 [cytosol] (R-HSA-8848007) p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) PTK6 [cytosol] (R-HSA-8848000) p-Y351-PTK6 [cytosol] (R-HSA-8857570) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103)	0.556	3
UniProt:A0A0S2Z4D7 A0A0S2Z4D7			0.556	3
UniProt:Q9NYB9-2 ABI2			0.556	5
UniProt:Q9UKS6 PACSIN3	1	PACSIN3 [cytosol] (R-HSA-8868270)	0.556	3
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.553	2
UniProt:A6NGB9 WIPF3	1	WIPF3 [cytosol] (R-HSA-2197670)	0.547	2
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.547	2
UniProt:Q9ESJ4	1	Nckipsd [cytosol] (R-MMU-2197671)	0.544	2
UniProt:Q8R511	1	Fnbp1 [cytosol] (R-RNO-8862261)	0.524	2
UniProt:Q9Y5X1 SNX9	3	SNX9 [Golgi membrane] (R-HSA-432988) SNX9 [cytosol] (R-HSA-8867737) SNX9 [cytoplasmic vesicle membrane] (R-HSA-432990)	0.524	2
UniProt:P16333-1 NCK1			0.499	2

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