Association of profilin with monomeric actin

Stable Identifier
R-HSA-203070
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Profilins PFN1 and PFN2 bind to monomeric actin (G-actin), forming a 1:1 complex and subsequently regulate actin filament barbed end assembly downstream of various signaling pathways (Pring et al. 1992, Korenbaum et al. 1998, Nodelman et al. 1999)

Literature References
PubMed ID Title Journal Year
1737036 Profilin-actin complexes directly elongate actin filaments at the barbed end

Pring, M, Weber, A, Bubb, MR

Biochemistry 1992
10600384 X-ray structure determination of human profilin II: A comparative structural analysis of human profilins

Nodelman, IM, Bowman, GD, Lindberg, U, Schutt, CE

J Mol Biol 1999
9649308 The role of profilin in actin polymerization and nucleotide exchange

Korenbaum, E, Nordberg, P, Björkegren-Sjögren, C, Schutt, CE, Lindberg, U, Karlsson, R

Biochemistry 1998
Participants
Participant Of
Orthologous Events
Authored
Reviewed