WWTR1 binds SMAD2/3:SMAD4 heterotrimer

Stable Identifier
R-HSA-2031355
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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In the cytosol of human embryonic stem cells, WWTR1 (TAZ) binds heterotrimer composed of two R-SMADs (SMAD2 and/or SMAD3) and SMAD4. This interaction involves the C-terminus of WWTR1 (TAZ) and the MH1 domain of SMAD proteins.
Literature References
PubMed ID Title Journal Year
18568018 TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

Wrana, JL, Peerani, R, Rao, BM, Samavarchi-Tehrani, P, Sakuma, R, Zandstra, PW, Varelas, X, Yaffe, MB, Dembowy, J

Nat Cell Biol 2008
Participants
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Orthologous Events
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