Reactome | TEAD2 [nucleoplasm]

TEAD2 [nucleoplasm]

Stable Identifier

R-HSA-2032763

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcriptional enhancer factor TEF-4

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q15562 TEAD2

Gene Names

TEAD2, TEF4

Chain

chain:1-447

Reference Genes

BioGPS Gene:8463 TEAD2

COSMIC (genes):TEAD2 TEAD2

CTD Gene:8463 TEAD2

dbSNP Gene:8463 TEAD2

ENSEMBL:ENSG00000074219 TEAD2

ENSEMBL_homo_sapiens_GENE:ENSG00000074219.14 TEAD2

HGNC:11715 TEAD2

KEGG Gene (Homo sapiens):8463 TEAD2

Monarch:8463 TEAD2

NCBI Gene:8463 TEAD2

OMIM:601729 TEAD2

UCSC:Q15562 TEAD2

Reference Transcript

Other Identifiers

11741366_a_at

11746218_a_at

11747989_a_at

11758665_s_at

16874273

226408_PM_at

226408_at

238322_PM_s_at

238322_s_at

238323_PM_at

238323_at

243766_PM_s_at

243766_s_at

3867791

3867792

3867797

3867798

3867799

3867800

3867801

3867802

3867804

3867808

3867809

3867811

3867813

3867814

3867817

3867819

3867820

3867821

3867822

3867823

3867824

3867825

55675_at

79112_r_at

8038347

8463

A_23_P119344

GE78998

GO:0000785

GO:0000978

GO:0000981

GO:0001223

GO:0001570

GO:0001843

GO:0003143

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0007399

GO:0023052

GO:0030154

GO:0030903

GO:0035329

GO:0043226

GO:0043231

GO:0045893

GO:0045944

GO:0048339

GO:0048368

GO:0048568

GO:0048856

GO:0060485

GO:0065003

GO:0071300

GO:0097718

GO:0140110

GO:0140552

GO:1990837

GO:2000736

HMNXSV003007083

HMNXSV003028936

Hs.153053.1.A1_3p_at

Hs.166556.0.S1_3p_s_at

Hs.166556.1.S1_3p_a_at

ILMN_1682781

PH_hs_0010025

TC19001713.hg

p8405

p8406

Participates

as an input of

YAP1 binds TEAD2 (Homo sapiens)

as a member of

TEADs [nucleoplasm] (Homo sapiens)

as a component of

TEAD2:YAP1 [nucleoplasm] (Homo sapiens)

as a candidate of

TEAD1,TEAD4,(TEAD2,TEAD3) [nucleoplasm] (Homo sapiens)

Inferred To

egl-44 [nucleoplasm] (Caenorhabditis elegans)

tead4 [nucleoplasm] (Xenopus tropicalis)

sd [nucleoplasm] (Drosophila melanogaster)

TEAD2 [nucleoplasm] (Bos taurus)

TEAD2 [nucleoplasm] (Canis familiaris)

TEAD2 [nucleoplasm] (Sus scrofa)

TEC1 [nucleoplasm] (Saccharomyces cerevisiae)

Tead2 [nucleoplasm] (Mus musculus)

Tead2 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

XP_011525705.1, NP_003589.1, NP_001243590.1, NP_001243588.1, XP_006723487.1, NP_001243591.1, NP_001243587.1, NP_001243589.1

Guide to Pharmacology - Targets

3241

OpenTargets

ENSG00000074219

GeneCards

Q15562

HPA

ENSG00000074219-TEAD2

Ensembl

ENSP00000310701, ENSP00000472109, ENST00000601519, ENST00000593945, ENST00000539846, ENSP00000437928, ENSP00000366419, ENSG00000074219, ENSP00000469672, ENSP00000469640, ENST00000598810, ENST00000377214, ENST00000311227

PRO

Q15562

Pharos - Targets

Q15562

PDB

5DQE, 6CDY, 7T2K, 3L15, 8CUH, 6S69, 5HGU, 6VAH, 6S60, 7TYU, 7T2L, 8E1O, 5EMV, 6S64, 7OYJ, 7TYQ, 7T2M, 6UYB, 6S6J, 7T2J, 6S66, 6E5G, 5DQ8, 7TYP, 6UYC

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46937 YAP1	7	p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322)	0.773	6
UniProt:Q5TBC7 B2L15			0.61	4
UniProt:Q15853 USF2	1	USF2 [nucleoplasm] (R-HSA-9023564)	0.556	3
UniProt:Q9GZV5 WWTR1	3	p-S89-WWTR1 [cytosol] (R-HSA-2028665) WWTR1 [nucleoplasm] (R-HSA-1629775) WWTR1 [cytosol] (R-HSA-1629773)	0.527	2
UniProt:P0DJI9 SAA2			0.488	2