Translocation of WWTR1 (TAZ) to the nucleus

Stable Identifier
R-HSA-2032768
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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Translocation of WWTR1 (TAZ) to the nucleus
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In its unphosphorylated state, the WWTR1 (TAZ) transcriptional coactivator moves freely into the nucleus. Phosphorylated WWTR1 (TAZ), in contrast, is sequestered in the cytosol (Lei et al. 2008).
Literature References
PubMed ID Title Journal Year
18227151 TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway

Lei, Q, Guan, KL, Xiong, Y, Pei, XH, Zhang, H, Zha, ZY, Zhao, B, Bai, F, Zhao, S

Mol Cell Biol 2008
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Orthologous Events
Translocation of WWTR1 (TAZ) to the nucleus (Bos taurus)
Translocation of WWTR1 (TAZ) to the nucleus (Caenorhabditis elegans)
Translocation of WWTR1 (TAZ) to the nucleus (Canis familiaris)
Translocation of WWTR1 (TAZ) to the nucleus (Danio rerio)
Translocation of WWTR1 (TAZ) to the nucleus (Gallus gallus)
Translocation of WWTR1 (TAZ) to the nucleus (Mus musculus)
Translocation of WWTR1 (TAZ) to the nucleus (Rattus norvegicus)
Translocation of WWTR1 (TAZ) to the nucleus (Sus scrofa)
Translocation of WWTR1 (TAZ) to the nucleus (Xenopus tropicalis)
Authored
D'Eustachio, P  (2012-02-03)
Reviewed
Sudol, M  (2012-02-03)
Created
D'Eustachio, P  (2012-01-07)
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